Protein Alignment sima and ahr-1

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_001021036.1
• Gene: ahr-1 / 172788
• WormBaseID: WBGene00000096
• Length: 602
• Species: Caenorhabditis elegans
• Alignment Length: 719
• Identity: 145/719 - (20%)
• Similarity: 255/719 - (35%)
• Gaps: 192/719 - (26%)

  Fly   134 YAPTNTQPCQFSQFVDIEDFMNNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKA 198
            ||....|. .|.:..|....:.|....::.|:    |.:.|.|   .::..||..:..:::|||.
 Worm     2 YASKRRQR-NFKRVRDPPKQLTNTNPSKRHRE----RLNGELE---TVAMLLPYDSSTISRLDKL 58

  Fly   199 SVMRITIAFLKIREMLQF--------------------------------VPSLRDCNDDIKQDI 231
            ||:|:.::||:.:...|.                                ||::.|
 Worm    59 SVLRLAVSFLQCKAHFQACLHNSQFLSAGFPMSTHSYSYQPHPPIPFSNKVPTIFD--------- 114

  Fly   232 ETAEDQQEVKPKLEVGTEDWLNGAEA--RELLKQTMDGFLLVLSHEGDITYVSENVVEYLGITKI 294
                        |.:|| ..|:..|:  .|:..:::.||:|||:..|:|.|.||||..|||..:.
 Worm   115 ------------LRIGT-PMLDPEESNFEEISLKSLGGFILVLNDNGEIYYASENVENYLGFHQS 166

  Fly   295 DTLGQQIWEYSHQCDHAEIKEALS----LKRELAQKVKD--EPQQNSGVSTHHRDLFVRLKCTLT 353
            |.|.|.:::..|..|..:|::.|.    :....|....|  .||.:..:   .|::..|.:|.|.
 Worm   167 DVLHQPVYDLIHSEDRDDIRQQLDSNFHIPTSSASNQFDVFAPQNSKYL---ERNVNARFRCLLD 228

  Fly   354 S---------RGRSINIKS--ASYKVIHITGHLVVNAKGERL-LMAIGRPIPHPSNIEIPLGTST 406
            :         ||:.:::..  :||    :.|.   .|.|..| ::.:..|...||..::......
 Worm   229 NTCGFLRIDMRGKLMSLHGLPSSY----VMGR---TASGPVLGMICVCTPFVPPSTSDLASEDMI 286

  Fly   407 FLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSRYR 471
            ..|||.||.....:|.|::::|.....| |...|::..|..|:..:....|..:..|......||
 Worm   287 LKTKHQLDGALVSMDQKVYEMLEIDETD-LPMPLYNLVHVEDAVCMAEAHKEAIKNGSSGLLVYR 350

  Fly   472 FLG-KYGGYCWILSQATIVYDKLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAE 535
            .:. |.....::.|...:.|...||:|:...:.:::.:|.          |...|::       .
 Worm   351 LVSTKTRRTYFVQSSCRMFYKNSKPESIGLTHRLLNEVEG----------TMLLEKR-------S 398

  Fly   536 TEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPV-TATST 599
            |.|....:.|...:        .:|.:.....|.||....:..:..:|.:.:.:..|.| ..|.|
 Worm   399 TLKAKLLSFDDSFL--------QSPRNLQSTAALPLPSVLKDDQDCLEPSTSNSLFPSVPVPTPT 455

  Fly   600 ADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGS-SSGLRPEEKRPKSVTASVLRP 663
            ..:..:..:.|.::       ::......|.|.....|:...| :.|:     .|.:....|...
 Worm   456 TTKANRRRKENSHE-------IVPTIPSIPIPTHFDMQMFDPSWNHGV-----HPPAWPHDVYHL 508

  Fly   664 SPAPPLTPPPTAVL----CKKTPL---GVEPN------LPPTTTATAAIISSSNQQL-----QIA 710
            :..||..|.|...:    .:..|:   |..||      ||...|..|       |:|     |::
 Worm   509 TQYPPTYPHPPGTVGYPDVQIAPVDYPGWHPNDIHMTQLPHGFTPDA-------QKLVPPHPQMS 566

  Fly   711 QQTQLQNPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHH-LASTNCIQLDEMTPFSDMLVG 774
            ..|:...|                          ....||.|| |...|...:.|:|       .
 Worm   567 HFTEYPTP--------------------------STHHDLHHHPLKQDNFHLISEVT-------N 598

  Fly   775 LMGT 778
            |:||
 Worm   599 LLGT 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	14/56 (25%)
		PAS	256..392	CDD:395786	40/155 (26%)
		PAS	265..>317	CDD:238075	21/51 (41%)
		PAS	404..505	CDD:238075	23/101 (23%)
ahr-1	NP_001021036.1	bHLH-PAS_AhR_like	20..78	CDD:381539	16/64 (25%)
		PAS	137..>195	CDD:238075	22/57 (39%)
		PAS_3	298..378	CDD:430001	17/80 (21%)