| Sequence 1: | NP_001287599.1 | Gene: | sima / 43580 | FlyBaseID: | FBgn0266411 | Length: | 1593 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_034267.3 | Gene: | Epas1 / 13819 | MGIID: | 109169 | Length: | 874 | Species: | Mus musculus |
| Alignment Length: | 947 | Identity: | 260/947 - (27%) |
|---|---|---|---|
| Similarity: | 410/947 - (43%) | Gaps: | 238/947 - (25%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 155 NNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPS 219
Fly 220 LRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSEN 284
Fly 285 VVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKR--ELAQKVKDEPQQNSGVSTHHRDLFVR 347
Fly 348 LKCTLTSRGRSINIKSASYKVIHITGHLVV-----------NAKGERL--LMAIGRPIPHPSNIE 399
Fly 400 IPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQ 464
Fly 465 GETSRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQ------- 520
Fly 521 -TAASEQKEQHHQAAETEK----------EPEKAA-------DPEIIAQETKETVNTPIHTSELQ 567
Fly 568 AKPLQ-----LESEKAEK--------TIEETKTIATIPPVTATSTADQIKQLPE------SNPYK 613
Fly 614 -QILQAELLIKRENHSPG-PRTITAQL----------LSGSS---SGLRPEEKRPKSVTASVLRP 663
Fly 664 SPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDM--- 725
Fly 726 --SKGFCS---------LFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTC 779
Fly 780 LLPEDINSLDSTTCSTTAS-------------GQHYQSPS----------------------SSS 809
Fly 810 TSAPSNTSSSNNSYAN-----SPLSPLTPNSTATASNPSHQQQQQHHNQQQQQQQQQQHHPQHHD 869
Fly 870 NSNSSSNID-----PLFNYREESND---------TSCSQHLHSPSITSKSPEDSSLPSL----CS 916
Fly 917 PNSLTQEDDFSFEAFAMRAPYIPIDDDMPLLTETDLM 953 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| sima | NP_001287599.1 | HLH | 156..209 | CDD:238036 | 34/52 (65%) |
| PAS | 256..392 | CDD:279347 | 53/150 (35%) | ||
| PAS | 265..>317 | CDD:238075 | 19/51 (37%) | ||
| PAS | 404..505 | CDD:238075 | 44/102 (43%) | ||
| PAS_3 | 417..502 | CDD:285623 | 34/86 (40%) | ||
| Epas1 | NP_034267.3 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..23 | 8/11 (73%) | |
| HLH | 12..68 | CDD:238036 | 35/55 (64%) | ||
| DNA-binding. /evidence=ECO:0000269|PubMed:26245371 | 26..53 | 14/26 (54%) | |||
| PAS | 86..147 | CDD:214512 | 21/78 (27%) | ||
| Required for heterodimer formation with ARNT. /evidence=ECO:0000269|PubMed:26245371 | 171..192 | 12/20 (60%) | |||
| PAS | 241..340 | CDD:238075 | 40/98 (41%) | ||
| PAS_3 | 254..341 | CDD:285623 | 34/86 (40%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 438..489 | 9/50 (18%) | |||
| NTAD | 495..541 | 7/45 (16%) | |||
| HIF-1 | 516..548 | CDD:288296 | 5/31 (16%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 777..803 | 6/25 (24%) | |||
| CTAD | 834..874 | 12/58 (21%) | |||
| HIF-1a_CTAD | 837..873 | CDD:285931 | 10/50 (20%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C167847523 | |
| Domainoid | 1 | 1.000 | 82 | 1.000 | Domainoid score | I8395 |
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 1 | 1.000 | - | - | FOG0000232 | |
| OrthoInspector | 1 | 1.000 | - | - | otm44237 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_106128 | |
| Panther | 1 | 1.100 | - | - | O | PTHR23043 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X1038 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 8 | 7.840 | |||||