Protein Alignment sima and LOC1279488

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: XP_061513965.1
• Gene: LOC1279488 / 1279488
• VectorBaseID: AGAMI1_006591
• Length: 647
• Species: Anopheles gambiae
• Alignment Length: 772
• Identity: 181/772 - (23%)
• Similarity: 283/772 - (36%)
• Gaps: 285/772 - (36%)

  Fly   160 KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCN 224
            ||||::|||.||.||...|:||:..|||.:...:||||||::|:|.::||:|::
Mosquito    25 KEKSKNAARSRREKENVEFLELAKLLPLPSAITSQLDKASIIRLTTSYLKMRQI----------- 78

  Fly   225 DDIKQDIETA--EDQQEVKPKLEVGTEDWLNG--AEAREL---LKQTMDGFLLVLSHEGDITYVS 282
              ..:.:.||  .|:.. :|          ||  |..:||   |.||:|||:.|::.:|.|||:|
Mosquito    79 --FPEGLGTAWGTDRNH-QP----------NGRAANIKELGSHLLQTLDGFIFVVAPDGKITYIS 130

  Fly   283 ENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKR-------------------------- 321
            |....:||:::::..|..|:||.|..|..|:...|:|::
Mosquito   131 ETASVHLGLSQVELTGNSIYEYIHAYDQEEMASILALQQPHHPLACSAPHNLPTSSTSLNSPNSL 195

  Fly   322 ------------------------------------------------------ELAQKVKDEPQ 332
                                                                  .:.|.||.|..
Mosquito   196 GTPWTGTFQVGSSATDSGYNEASSEAPVTLASCQQQQHQQQQQQQQQNHQYYVPSIPQAVKCEST 260

  Fly   333 QNSGVSTHH--------------------RDLFVRLKCTLTSRGRSINIKSASYKVIHITGHL-- 375
            |......||                    |:.|:|::|.|..  |:..:.|:.|||||.:|:|
Mosquito   261 QIHCQQNHHQPNHRHSYSQHQRSYVVDMERNFFLRMRCVLAK--RNAGLTSSGYKVIHCSGYLKA 323

  Fly   376 ------VVNAKG----ERL-LMAIGRPIPHPSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLG 429
                  .:|..|    :.| |.|:|..:...:..|:.|..:.|:.:.||||:..|:|.|:..|.|
Mosquito   324 RVFPHESLNTPGYCCVQNLGLEAVGHSLSPSAATEVKLQQNMFMFRASLDMKLIYLDAKVSQLTG 388

  Fly   430 YSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYD--K 492
            |.|:||::.:|:...|.:|..::..|.:::|.|||..|..||||.|.||:.|:.|.||||::  .
Mosquito   389 YEPQDLIENTLYQYIHASDVVQVRQTHQTLLQKGQATTMYYRFLTKAGGWRWVQSHATIVHNTRS 453

  Fly   493 LKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKE----------QHHQAAETEKEPEKAADPE 547
            .:|..:|.||||:|:.|.::...:.:|...:|.:..          .||.||..|....||.:.
Mosquito   454 SRPHCIVSVNYVLSDFEAQNLQLNESQGAKSSLRSSFEMFNFTPTTHHHSAASEECMSAKAFNG- 517

  Fly   548 IIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTATSTADQIKQLPESNPY 612
                      |..:.|.| ::....|..|....:||..|.|........|..:::...:.|.|.
Mosquito   518 ----------NQQLSTHE-ESLAFNLPPEPLAPSIEPCKEIDNFLNFHHTLKSNESTSIAELNG- 570

  Fly   613 KQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAVL 677
                                       ||:.....|.:                          |
Mosquito   571 ---------------------------SGNDDSFLPND--------------------------L 582

  Fly   678 CKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLFADDGRGLTM 742
            |                        .:|..|...||||..|.:.||..:.|
Mosquito   583 C------------------------YDQSSQFTTQTQLSYPFEDAQSFTSG-------------- 609

  Fly   743 LKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTASG 799
                                :.:.||.:.|.....|  .|.| ..|...:||.:.||
Mosquito   610 --------------------EFLDPFYEQLYSTYET--HPPD-RDLILRSCSVSTSG 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	28/55 (51%)
		PAS	256..392	CDD:395786	53/251 (21%)
		PAS	265..>317	CDD:238075	19/51 (37%)
		PAS	404..505	CDD:238075	41/102 (40%)
LOC1279488	XP_061513965.1	None