Protein Alignment sima and tgo

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: XP_061516546.1
• Gene: tgo / 1279156
• VectorBaseID: AGAMI1_006771
• Length: 882
• Species: Anopheles gambiae
• Alignment Length: 951
• Identity: 207/951 - (21%)
• Similarity: 318/951 - (33%)
• Gaps: 334/951 - (35%)

  Fly    47 PAF--GPMPINEPTVNFGNGSFYNGPAPGSQPFVGAMLGPNMSSTGMQRYHPYHQQQPQD----- 104
            ||:  |..|....|:.    ||.|.|.|.:      :||.:.:|       |:|...|..
Mosquito    33 PAYHHGGSPTPPSTIT----SFNNVPGPST------LLGHHYAS-------PHHMPPPPPPPLPS 80

  Fly   105 -------------AFYRQRGSLLNVATPCRESRPWSYAYCYGYAPTNTQPCQFSQFVDI------ 150
                         ..:..:.:....|.        :.|...|.:|..|.|    |..::
Mosquito    81 AAASAVAAAGVAAVSHNHQAAAAAAAA--------AAAVAAGVSPMQTDP----QLTELAPSLGG 133

  Fly   151 --------EDF--------MNNEKRKEKSRDAAR---C-----RRSKETEIFMELSAALPLKTDD 191
                    ||.        |:.:..::|.|.|:|   |     ||:|.|....|||..:|..:..
Mosquito   134 ITKRRRSDEDTSSGNKYNRMDEDNVQDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSAL 198

  Fly   192 VNQLDKASVMRITIAFLKIREMLQFVPSLR---DCNDDIKQDIETAEDQQEVKPKLEVGTEDWLN 253
            ..:.||.:::|:.:|.:|         :||   :.|.|           ...||       .:|.
Mosquito   199 ARKPDKLTILRMAVAHMK---------ALRGTGNTNTD-----------GSYKP-------SFLT 236

  Fly   254 GAEARELLKQTMDGFLLVLSHE-GDITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEAL 317
            ..|.:.|:.:..||||.|...: |.|.|||::|...|..::.:.....::::.|..|..:::|.|
Mosquito   237 DQELKHLILEAADGFLFVAGCDTGRIIYVSDSVTPVLNYSQNEWYSGSLFDHIHPDDIEKVREQL 301

  Fly   318 SLK------RELAQK---VKDEPQQNS-----GVSTHHRDLFVRLKC-TLTSRGRSI-------- 359
            |.:      |.|..|   ||.|..|:|     |   ..|....|::. .||....::
Mosquito   302 STQEPVNSGRILDLKTGTVKKEGHQSSMRLCMG---SRRGFICRMRIGPLTPESMALGHLNRLRR 363

  Fly   360 ------NIKSASYKVIHITGHL-----------VVNAKGER--------LLMAIGRPIPHPSNIE 399
                  :....||.|:|.||::           |...:|:.        .|:||.|       ::
Mosquito   364 KNSLGPSTDGHSYAVMHCTGYIKNWPPTDMFPGVTIDRGQDDELHNTHCCLVAIAR-------LQ 421

  Fly   400 IPLGTST----------FLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMA 454
            |...|:.          |:::|::..:||:||.::..:|||.|.|||:.|.:...|..|...:..
Mosquito   422 ITSSTTANDLSANNPNEFISRHAMCGKFTFVDQRVIGVLGYQPVDLLNKSCYDFFHPDDIAHMKE 486

  Fly   455 TFKSVL-SKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKP-----QSVVCVNYVISNLENKHE 513
            .|..|| .|||..:..|||..|...:.|:.:||   |..|.|     :.|||.|.....|.:.|:
Mosquito   487 NFDQVLKQKGQMFSVMYRFRAKNKEWVWMRTQA---YAFLNPYTDDIEYVVCTNSSAKALHSSHD 548

  Fly   514 IYSLAQQTAASEQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKA 578
            ..:..:||                                    :||:  :...|..|..
Mosquito   549 TVTAPEQT------------------------------------DTPV--ASYPAPGLDY----- 570

  Fly   579 EKTIEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSS 643
                       |:|....|:.:..|     .||:..|          :|.|......||..:.||
Mosquito   571 -----------TLPGRRDTTPSSNI-----YNPHNLI----------SHLPSQPQTAAQAAAASS 609

  Fly   644 SGLRPEEKRPKSVTASV---LRPSPAP-----PLTPPPTAVLCKKTPLGVEP---NLPPTTTATA 697
            .      :||:|....|   ..|:|:|     |.||...|.    ..||..|   |..||..|||
Mosquito   610 I------QRPESAHNPVQYSYNPTPSPIQYGSPGTPSGGAA----GSLGHLPKTNNTSPTPAATA 664

  Fly   698 AIISSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQL 762
            ..:.......:..|.::|...:.|.              |...|.|.          ||.   |.
Mosquito   665 WTLRQPQPVTEGYQYSELSPNRSPT--------------GPTYTQLN----------ASR---QT 702

  Fly   763 DEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANSP 827
            ...||.|....|:.                 |...|..|...|....|.....|::.
Mosquito   703 STFTPSSQAGPGIW-----------------SGWQSHHHGTGPEPMQTGGSGGTTNG-------- 742

  Fly   828 LSPLTPNSTATASNPSHQQQQQHHNQQQQQQQQQQHHPQHH 868
                 |.|:.|:.....:....:..|||..|||||.||..|
Mosquito   743 -----PGSSHTSVGLGQEMATDNAQQQQHMQQQQQQHPALH 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	18/64 (28%)
		PAS	256..392	CDD:395786	44/184 (24%)
		PAS	265..>317	CDD:238075	15/52 (29%)
		PAS	404..505	CDD:238075	37/116 (32%)
tgo	XP_061516546.1	None