Protein Alignment sima and Clk

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: XP_061501162.1
• Gene: Clk / 1276380
• VectorBaseID: AGAMI1_003513
• Length: 1034
• Species: Anopheles gambiae
• Alignment Length: 1374
• Identity: 298/1374 - (21%)
• Similarity: 466/1374 - (33%)
• Gaps: 517/1374 - (37%)

  Fly   151 EDFMNNEKRKEKSRDAARCRRSKETEIFM-ELSAALPLKTDDVNQLDKASVMRITIAFLKIREML 214
            ||..:.:..|.|||:.:..:|..:..:.: |||:   :.:.:..::||::|::.||||||
Mosquito     3 EDPDDKDDTKRKSRNLSEKKRRDQFNLLVNELSS---MVSSNSRKMDKSTVLKSTIAFLK----- 59

  Fly   215 QFVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDIT 279
                    .:::|.......|.|.:.||       .:|:..|...|:.:.:|||::|.|..|.:.
Mosquito    60 --------SHNEIAVRSRVHEIQTDWKP-------SFLSNEEFTHLILEALDGFIIVFSSTGRVF 109

  Fly   280 YVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDL 344
            |.||::...||....|.|...:::..::.|..::...|     |......:|.| :|:|   |:.
Mosquito   110 YASESITSLLGHLPSDLLNMTVYDMVYEDDQNDLYNIL-----LNPTTVVDPLQ-TGIS---REN 165

  Fly   345 FVRLKCTLTSRGRSINIKSASYKVIHITGHLVVNAKGERLLMAIGRPIPHPSNIE---IPLGT-- 404
            .|...|.: .||........||:.:..||:...:...|. ||...|...:.|:.:   :.:||
Mosquito   166 QVTFSCYI-KRGTVDYRADVSYEHVQFTGYFRSDVDTES-LMTTSRFSGYTSDADSRLVFVGTGR 228

  Fly   405 -----------------STFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERL 452
                             |.|.::|||:.:|.::|.:...::||.|.::|.||.:...|..|.|::
Mosquito   229 LQTPQLIREMSIVDNTKSEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHFDDLEKV 293

  Fly   453 MATFKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYDK--LKPQSVVCVNYVISNLENKHEIY 515
            :|..::::.||:|.:..||||.|...:.|:.::..|.|.:  .||:.|||.:.|:|
Mosquito   294 VACHEALMQKGEGTSCYYRFLTKGQQWIWLQTRFYITYHQWNSKPEFVVCTHRVVS--------- 349

  Fly   516 SLAQQTAASEQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEK 580
                  .|...|:..:|.|...|..|.|....:...|.|...::  ..|.|...|...:|.:
Mosquito   350 ------YADVMKQMRNQTAGDSKFSEDADSISVHGIERKFQQSS--SQSLLATSPWSSKSSR--- 403

  Fly   581 TIEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSG 645
                |..||..|.|:.|..:::.:.  ..|.|              |.||         |.|::.
Mosquito   404 ----TSRIAPTPGVSPTGLSNRGRH--RYNTY--------------HGPG---------SDSATS 439

  Fly   646 LRPEE--KRPKSVT---ASVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQ 705
            :..|.  .|...||   .|.:|.|..|                              :.:||...
Mosquito   440 ISTESHTSRQSLVTQHSRSRMRTSTFP------------------------------SKVSSHGS 474

  Fly   706 QLQIAQQTQ--LQNPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPF 768
            |......:.  ||.||||                .|           .|.|
Mosquito   475 QSDRNSMSHFLLQQPQQP----------------HG-----------GHQL-------------- 498

  Fly   769 SDMLVGLMGTCLLPEDINSLDSTTCSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANSPLSPLTP 833
                                        ||||
Mosquito   499 ----------------------------ASGQ--------------------------------- 502

  Fly   834 NSTATASNPSHQQQQQHHNQQQQQQQQQQHHPQH---HDNSNSSSNIDPLFNYREESNDTSCSQ- 894
                      .|.||||..||||.|||||..|||   |...:      ||....::.......|
Mosquito   503 ----------LQHQQQHLPQQQQHQQQQQQQPQHPLQHQQPH------PLLQPHQQLQGHQAQQP 551

  Fly   895 HLHSPSITSKSPEDSSLPSLCSPNSLTQEDDFSFEAFAMRAPYIPIDDDMPLLTETDLMWCPPED 959
            |...|      |:....|::                               :...||:.   |..
Mosquito   552 HQQLP------PQQQPHPAM-------------------------------IQNPTDVY---PHQ 576

  Fly   960 LQTMVPKEIDAIQQQLQQ--------LQQQHHQQYA-----GNTGYQQQQQQPQLQQ-QHFSNSL 1010
            |||..|     :|||.||        .|||.|||.|     |....||..||||.|| ||.....
Mosquito   577 LQTQHP-----LQQQQQQQQQPQQPSQQQQSHQQLAGLQQPGTVQQQQSHQQPQHQQPQHQQPQQ 636

  Fly  1011 CSSP---ASTVSSLSPSPV-------------------QQHHQQ---QQAAVFTSDS-SELAALL 1049
            ...|   .||.::|.|.|.                   ||:...   |..|.||..: ..|:.:.
Mosquito   637 QQPPLPQPSTTAALRPPPATIITPPVTQILTATGFIEPQQYLTAIPVQSVAGFTETAPGVLSPIQ 701

  Fly  1050 CGSGNGTLSILAGSGVTVAEECNERLQQHQQQQQQTSGNEFRTFQ-QLQQELQLQEEQQQRQQQQ 1113
            ..|.:|..::.....||                 .|.|......| |:|.:||.:.|:.|....|
Mosquito   702 STSPHGAYAVAHHPAVT-----------------GTGGVVLTPSQNQVQDQLQRKHEELQHLILQ 749

  Fly  1114 QQQQQQQQQQQLLSLNIECKKEKYDV------------------------------QMGGSL--C 1146
            ||::.::.|:|||       ..:|.:                              ..|||.  .
Mosquito   750 QQEELRRVQEQLL-------MARYGLLPSIVSLPFPPGTGNGPGPGPSVGPPGERCASGGSFLQA 807

  Fly  1147 HPMEDAFENDYSKDSANLDCWDLIQMQVVDTEPVSPNAASPTPCKVSAIQLLQQQQQLQQQQQQQ 1211
            |...:::.:.:                      ..|:||             |.|||.||||||.
Mosquito   808 HHQGNSYHHHH----------------------YHPSAA-------------QAQQQQQQQQQQH 837

  Fly  1212 QNIILNAVPLITIQNNKELMQQQQQQQQQQQQEQL------QQPAI------------------- 1251
            .            .::..:...||.|...|.|:||      |:|.:
Mosquito   838 P------------PSHGGVHHAQQPQHPLQDQQQLCIGPPDQKPILHPDPEQLNFTDTGQGKLGE 890

  Fly  1252 --KLLNGASIAPV-----NTKATIRLVESKPPTTTQSRMAKVNLVPQQQQHGNKRHL------NS 1303
              ::::...:.||     ..:::.....|.|.|:..|:..|.:   |||||..::|:      :.
Mosquito   891 PNEMISYMQLTPVPLHHLQHQSSQSSTSSTPATSMMSQQQKQH---QQQQHQQQQHMQMGAPPDG 952

  Fly  1304 ATGAGNPVESKRLKSGTLCLDVQSPQLLQQLIGKDPAQ-------QQTQAAKRAGSERWQLSAES 1361
            .||||.  .|....:|      .:..|||..:..:.||       :|.|     |.::.|.:.:.
Mosquito   953 GTGAGG--NSNNNSNG------NTMGLLQYQMAAEQAQILFTSGMEQQQ-----GQQQQQPAVQQ 1004

  Fly  1362 KQQKQQQQQ 1370
            :||:|||||
Mosquito  1005 QQQQQQQQQ 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	17/57 (30%)
		PAS	256..392	CDD:395786	35/135 (26%)
		PAS	265..>317	CDD:238075	14/51 (27%)
		PAS	404..505	CDD:238075	34/121 (28%)
Clk	XP_061501162.1	None