Protein Alignment sima and LOC1276339

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: XP_061508161.1
• Gene: LOC1276339 / 1276339
• VectorBaseID: AGAMI1_010074
• Length: 851
• Species: Anopheles gambiae
• Alignment Length: 890
• Identity: 183/890 - (20%)
• Similarity: 301/890 - (33%)
• Gaps: 293/890 - (32%)

  Fly    37 QRQRQLSRNGPAF-------GPMPINEPTVNFGN--------------GSFYNGPAPGSQ----- 75
            |:|:||.::.|:.       |...:..|.:..|.              |:..|.|:..|.
Mosquito    55 QQQQQLHQSAPSHRTLVAGGGDGEVPNPVITTGGLLQNYHHHNVFYELGAATNSPSNASAVPTEH 119

  Fly    76 ----PFVGAMLGPNMSST-------------GMQRY--------HPYHQQQPQDAFYRQRGSLLN 115
                |....::.|:::.|             |...:        |.:|..|......|:|....|
Mosquito   120 MTGGPDASLLVDPSLAGTMSAVSNLSTLSAAGSGNHLLHLVDHGHSHHDHQHSAGGARKRKFSFN 184

  Fly   116 VATPCRESRPWSYAYCYGYAPTNTQPCQFSQFVDIEDFMNNEKRKEKSRDAARCRRSKETEIFME 180
            ..:...:                 ..|..|:.|...|    |.:|:...:..:.||.|......|
Mosquito   185 DTSDIED-----------------DTCDDSKSVRTAD----ESKKQNHSEIEKRRRDKMNTYITE 228

  Fly   181 LSAALPLKTDDVNQLDKASVMRITIAFLK-IREMLQFVPSLRDCNDDIKQDIETAEDQQEVKPKL 244
            |||.:|:......:|||.:|:|:.:..|| ||..:.                  :..:...||.
Mosquito   229 LSAMIPMCHAMSRKLDKLTVLRMAVQHLKTIRGAVH------------------SYTEGHYKPA- 274

  Fly   245 EVGTEDWLNGAEARELLKQTMDGFLLVLS-HEGDITYVSENVVEYLGITKIDTLGQQIWEYSHQC 308
                  :|:..|.:.|:.|..:|||.|:. ..|.|.||||:|...|..::.|.|||..::..|..
Mosquito   275 ------FLSDQELKMLILQAAEGFLFVVGCDRGRILYVSESVSHILNYSQGDLLGQSWFDILHPK 333

  Fly   309 DHAEIKEALSLK----RELAQKVK-------DEPQQNSGVST----HHRDLFVRLKC-------- 350
            |.|::||.||..    ||.....|       |.||   ||:.    ..|..|.|:||
Mosquito   334 DVAKVKEQLSSSDLSPRERLIDAKTMLPVKTDVPQ---GVTRLCPGARRSFFCRMKCKANVQVKE 395

  Fly   351 ------TLTS-------RGRSINIKSASYKVIHITGHL-------------VVNAKGE----RLL 385
                  :::|       |.:.:| ....|.||..||:|             ..:.:|:    ..|
Mosquito   396 EADQPNSVSSVNNVCHRRKKQVN-SDKKYSVIQCTGYLKSWAPAKIGLEENETDGEGDSCNLSCL 459

  Fly   386 MAIGRPIPH-----------------------------------------------------PSN 397
            :|:||..|:                                                     |||
Mosquito   460 VAVGRVQPNLSQSCSLSSNGLHTPSGANGGRSRNGSNAATGPGSGAGGGATGSSSNGNPSATPSN 524

  Fly   398 ---------IEIP-LGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERL 452
                     ..|| |....|:::|::|.:|.:||.:...:||:.|::||.||::...|..|...|
Mosquito   525 GSNGKQLNRNTIPNLRNVQFISRHAMDGKFLFVDQRATLVLGFLPQELLGTSMYEYYHHEDIPAL 589

  Fly   453 MATFKSVLSKGQG----ETSRYRFLGKYGGYCWILSQATIVYDKLKPQSVVCVNYVISNLENKHE 513
            ..:.|:.|   ||    .||.||...|..|:..:.|:    :...:......:.|:|:  :|...
Mosquito   590 AESHKAAL---QGTQCVTTSVYRLRTKETGFVRLQSE----WKSFRNPWTKEIEYLIA--KNNVI 645

  Fly   514 IYSLAQQTAASEQKEQHHQAAETEKEPEKAA--DPEI--------IAQETKETVNTPIHTSELQA 568
            :..|.....|........:..:...||...|  .|.:        ..:|.:..:|:.:..|
Mosquito   646 LAELGDGGTARAGGYGMGELGDGTGEPGSGAPGQPGVGYEFFNHTNGREIQRMINSHVEAS---- 706

  Fly   569 KPLQLESEKAEKTIEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAEL--LIKRENHSPGP 631
               ::..:.||:.::..:.:       ..|:::.     ..||.:..||...  .:...|||
Mosquito   707 ---KIGRQIAEQVLDHQRRV-------GDSSSES-----SPNPNEPTLQPAFSSALSEANHS--- 753

  Fly   632 RTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPP-TTTA 695
               ...:.||..|          .||::.:  ||:.....|||..      ..:...||. :...
Mosquito   754 ---NDAITSGEHS----------MVTSTGV--SPSSMAVVPPTVT------TRINGTLPGYSHVQ 797

  Fly   696 TAAIISSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLF-ADDGRG 739
            |.||||..:.    ..|||..:.....:.......||. ||.|.|
Mosquito   798 TNAIISPEHD----VSQTQASSTDGNDEAAMAVIMSLLEADAGLG 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	18/57 (32%)
		PAS	256..392	CDD:395786	53/189 (28%)
		PAS	265..>317	CDD:238075	21/52 (40%)
		PAS	404..505	CDD:238075	28/104 (27%)
LOC1276339	XP_061508161.1	None