Protein Alignment sima and Clock

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_031741.1
• Gene: Clock / 12753
• MGIID: 99698
• Length: 855
• Species: Mus musculus
• Alignment Length: 1189
• Identity: 247/1189 - (20%)
• Similarity: 401/1189 - (33%)
• Gaps: 404/1189 - (33%)

  Fly   139 TQPC-QFSQFVDIEDFM---------NNEKRKEKSRD-AARCRRSKETEIFMELSAALPLKTDDV 192
            |..| :.|..||.:|..         :.:|.|..||: :.:.||.:...:..||.:.||   .:.
Mouse     4 TVSCSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNA 65

  Fly   193 NQLDKASVMRITIAFLKIREMLQFVPSLRDCNDDIKQDIETAE-DQQEVKPKLEVGTEDW----L 252
            .::||::|::.:|.||:                  |....||: |..|::       :||    |
Mouse    66 RKMDKSTVLQKSIDFLR------------------KHKETTAQSDASEIR-------QDWKPTFL 105

  Fly   253 NGAEARELLKQTMDGFLLVLSHEGDITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEAL 317
            :..|..:|:.:.:|||.|.:..:|.|.||||:|...|.....|.:.|.|:.:..:.:|:|:.:.|
Mouse   106 SNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKIL 170

  Fly   318 SLKRELAQKVKDEPQQNSGVSTHHRDLFVRLK-----CTLTSRGRSINIKSASYKVIHITGHLVV 377
            |  ..|.:.....|:            :::.|     |....||.....:.::|:.:...|
Mouse   171 S--THLLESDSLTPE------------YLKSKNQLEFCCHMLRGTIDPKEPSTYEYVRFIG---- 217

  Fly   378 NAKG------------ERLLMAIGRP-------------------IPHPSNIEIPLGTSTFLTKH 411
            |.|.            |..:....||                   |.....:|.|  ...|.::|
Mouse   218 NFKSLTSVSTSTHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVEEP--NEEFTSRH 280

  Fly   412 SLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSRYRFLGKY 476
            ||:.:|.::|.:...::||.|.::|.||.:...|..|.|.|....:.::..|:|::..||||.|.
Mouse   281 SLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKGKSCYYRFLTKG 345

  Fly   477 GGYCWILSQATIVYDK--LKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAETEKE 539
            ..:.|:.:...|.|.:  .:|:.:||.:.|:|               .|..:.|:..:....|..
Mouse   346 QQWIWLQTHYYITYHQWNSRPEFIVCTHTVVS---------------YAEVRAERRRELGIEESL 395

  Fly   540 PEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTATSTADQIK 604
            ||.|||                               |::.:..:.: |.|:
Mouse   396 PETAAD-------------------------------KSQDSGSDNR-INTV------------- 415

  Fly   605 QLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPL 669
            .|.|:            ::|.:|||.|        |.||...|      ||...:|..||..|..
Mouse   416 SLKEA------------LERFDHSPTP--------SASSRSSR------KSSHTAVSDPSSTPTK 454

  Fly   670 TPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQ------------IAQQTQLQNPQQPA 722
            .|..|:     ||  ...:||.....|....|.|:|.:.            ::|...|..||..:
Mouse   455 IPTDTS-----TP--PRQHLPAHEKMTQRRSSFSSQSINSQSVGPSLTQPAMSQAANLPIPQGMS 512

  Fly   723 QDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINS 787
            |..       |:.....:..||::.:..:..:.:....|.:|:....:.|..:.|..|
Mouse   513 QFQ-------FSAQLGAMQHLKDQLEQRTRMIEANIHRQQEELRKIQEQLQMVHGQGL------- 563

  Fly   788 LDSTTCSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANSPLSPLTPNSTATASNPSHQQQQQHHN 852
                        |.:...|:...    |..|...|..||.:..|||.:......|::|.|..|.:
Mouse   564 ------------QMFLQQSNPGL----NFGSVQLSSGNSNIQQLTPVNMQGQVVPANQVQSGHIS 612

  Fly   853 QQQQQQQQQQHHPQHHDNSNSSSNIDPLFNYREESNDTSCSQHLHSPSITSKSPEDSSLPSLCSP 917
            ..|...|||                      ..:|..|..||.    |:.|...:.:||||. :|
Mouse   613 TGQHMIQQQ----------------------TLQSTSTQQSQQ----SVMSGHSQQTSLPSQ-TP 650

  Fly   918 NSLTQEDDFSFEAFAMRAPYIPIDDDMPLLTETDLMWCPPEDLQTMVPKEIDAIQQQLQQLQQQH 982
            ::||             ||          |..|.::..|.......:|..:           .|:
Mouse   651 STLT-------------AP----------LYNTMVISQPAAGSMVQIPSSM-----------PQN 681

  Fly   983 HQQYAGNTGYQQQQQQPQLQQQHFSNSLCSSPASTVSSLSPSPVQQHHQQQQAAVFTSDSSELAA 1047
            ..|.|..|.:.|.:|....|.|.....|.::|.:..:.:.||
Mouse   682 STQSATVTTFTQDRQIRFSQGQQLVTKLVTAPVACGAVMVPS----------------------- 723

  Fly  1048 LLCGSGNGTLSILAGSGVTVAEECNERLQQHQQQQQQTSGNEFRTFQQLQQELQLQEEQQQRQQQ 1112
                      ::|.|..||.....     ..||||.||          |....|.|::|||..||
Mouse   724 ----------TMLMGQVVTAYPTF-----ATQQQQAQT----------LSVTQQQQQQQQQPPQQ 763

  Fly  1113 QQQQQQQQQQQQLLSLNIECKKEKYDVQMGGSLCHPMEDAFENDYSKDSANLDCWDLIQMQVVDT 1177
            ||||||..|:|||.|:.
Mouse   764 QQQQQQSSQEQQLPSVQ------------------------------------------------ 780

  Fly  1178 EPVSPNAASPTPCKVSAIQLLQQQQQLQQQQQQQQNIILNAVPLITIQNNKELMQQQQQQQQQQQ 1242
            :|.......|..      |.||..:.|......|  :||:|.  ..:|.:.......||.|.|||
Mouse   781 QPAQAQLGQPPQ------QFLQTSRLLHGNPSTQ--LILSAA--FPLQQSTFPPSHHQQHQPQQQ 835

  Fly  1243 QEQLQQPAIKLLNGASIAP 1261
            |:..:.....|.:.:.:.|
Mouse   836 QQLPRHRTDSLTDPSKVQP 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	15/57 (26%)
		PAS	256..392	CDD:395786	34/171 (20%)
		PAS	265..>317	CDD:238075	17/51 (33%)
		PAS	404..505	CDD:238075	29/102 (28%)
Clock	NP_031741.1	bHLH-PAS_CLOCK	29..89	CDD:381577	17/80 (21%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:19414601	32..47		4/14 (29%)
		PAS	109..>175	CDD:395786	21/67 (31%)
		PAS_11	274..377	CDD:464214	30/102 (29%)
		Interaction with NR3C1. /evidence=ECO:0000269|PubMed:19141540	371..854		151/772 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..411		7/49 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..497		25/109 (23%)
		Interaction with SIRT1. /evidence=ECO:0000269|PubMed:18662547	450..570		25/152 (16%)
		Implicated in the circadian rhythmicity	514..564		8/75 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..650		14/63 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	752..791		19/86 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	814..855		10/43 (23%)