Protein Alignment sima and sima

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: XP_061502141.1
• Gene: sima / 1273021
• VectorBaseID: AGAMI1_008407
• Length: 1697
• Species: Anopheles gambiae
• Alignment Length: 1811
• Identity: 581/1811 - (32%)
• Similarity: 807/1811 - (44%)
• Gaps: 540/1811 - (29%)

  Fly    30 YECDSKPQRQRQLSRN-----GPAFGPMPINEPTVNFGNGSFYNGPAPGSQP-FVGAMLG----- 83
            |:...:.|:|.|:..|     |.|:.|.....|            |.|..|| ..|..||
Mosquito    42 YQHQQQQQQQPQVPSNNHHLVGGAYQPFCQALP------------PPPARQPSSYGVELGESPEL 94

  Fly    84 ----PNMSSTGMQRYHPYHQQQPQDAFYRQRGSLLNVAT---PCRESRPWSYAYCYGYAPTNTQP 141
                .||.|.|.....|...:||.            ||.   ||:...||:|||||||  ...:|
Mosquito    95 VSLPQNMISAGGSSSSPSFLEQPY------------VAANYPPCQGPPPWNYAYCYGY--YGQEP 145

  Fly   142 CQFSQFVDIEDFMNNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIA 206
            |.:...||:||||||||||||||||||||||:|||||.:|::.||::.::|..||||||||::||
Mosquito   146 CPYVNMVDMEDFMNNEKRKEKSRDAARCRRSRETEIFQDLASLLPMRPEEVEHLDKASVMRLSIA 210

  Fly   207 FLKIREMLQFVPSLRDCND-DIKQD----IETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMD 266
            |||.|.||:..|..:.... .||:|    :::.|:.|..:.||.:.:    .|.:...:..||:|
Mosquito   211 FLKARNMLELFPDFQSKEQITIKEDNDVSMDSMEEFQYNEAKLSLKS----LGLDPETIALQTLD 271

  Fly   267 GFLLVLSHEGDITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKR----ELAQKV 327
            |||::||.:||:|||||||.|||||::||.:||.||:|||||||.|::|||:.:.    ||...|
Mosquito   272 GFLIILSADGDVTYVSENVNEYLGISQIDIMGQPIWDYSHQCDHDELREALNGRHHSPSELLNGV 336

  Fly   328 KD---EPQQNSGVSTHHRDLFVRLKCTLTSRGRSINIKSASYKVIHITGHLVVNAK-GERLLMAI 388
            .:   .|.:|       ||.|:||||||||||||:|||||||||:|:|||:....| |:|.|:||
Mosquito   337 ANSDCRPMEN-------RDFFLRLKCTLTSRGRSVNIKSASYKVLHVTGHIACKDKEGQRQLVAI 394

  Fly   389 GRPIPHPSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLM 453
            .||:|||:|||:|||:|||||:|:|.|:|:||||.|..||||.|.|||..||:.|.||.|:|.||
Mosquito   395 ARPLPHPANIEVPLGSSTFLTQHTLGMKFSYVDDIMLSLLGYKPSDLLGKSLYDCHHGTDAEHLM 459

  Fly   454 ATFKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKPQSVVCVNYVISNLENKHEIYSLA 518
            :|||.|:||||.||||||||.|.|||.|:::|||::|||.||.||||||||:|.:|||.||.|.|
Mosquito   460 STFKHVISKGQSETSRYRFLAKTGGYAWVVTQATVIYDKQKPHSVVCVNYVLSGVENKDEILSCA 524

  Fly   519 QQTAASEQKEQHHQAAETEKEPEKAAD--------------PEIIAQETKETVNTPIHTSELQAK 569
            |..|..:...|         ||:|.|:              .::::.|.......||..:..|..
Mosquito   525 QLEARQQLLSQ---------EPDKCAESNSNHSVVCSSNSNDQLLSVEPAVKTVVPIAAAVAQRA 580

  Fly   570 PLQLESEKAEKTIEETKTIATIPP--------------VTATSTADQIKQLPESNPYKQILQA-- 618
            .| :|..|||:||       .|||              :.|...|||      :|...::|.:
Mosquito   581 GL-VEEVKAEETI-------AIPPSSNLAEPTVVPYVKLVANIGADQ------NNGNDELLASVG 631

  Fly   619 -ELLIKRENHSPG---------------------PRTITAQLLSGSSSGLRPEEKRPKSVTASV- 660
             ::|:..:|.:|.                     |.|:..:..|.:.|       ||.|||||:
Mosquito   632 DKVLLCVKNDTPTVVSGEQPVPLHSRALRELNTVPATVPPKPASSTIS-------RPVSVTASIF 689

  Fly   661 --LRPSPAPPLTPPPTAVLCKKTPLGVEPN--------LPPT--------TTATAAIISSSNQQL 707
              |.|......|......:.|.|..|...:        |||.        |||     ..|..:.
Mosquito   690 TSLPPGTGASGTADKARAVNKPTGWGAPQSVTAKLFVTLPPPPVGAGIGGTTA-----GPSGSKP 749

  Fly   708 QIAQQTQLQNPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLAST---NCIQLDEM-TPF 768
            |.|.: ::..|:  .:||:|||. :|:::..||||||:|||||: |||.|   .||.|:|. |.|
Mosquito   750 QHATE-KIFAPR--TEDMNKGFL-MFSEEEPGLTMLKDEPDDLT-HLAPTAGDACIPLEESGTFF 809

  Fly   769 SDMLVGLM---GTCLLPEDINSLDS------------------------------------TTCS 794
            ::|....:   ...||.:::.||||                                    |..|
Mosquito   810 NEMFEDFIIPDSYTLLQDELCSLDSQDTRLDASSIVVHPVSTSDSLTSSLSVASVASLPLGTAVS 874

  Fly   795 TTASG---------------------QHYQSPSSSSTSA-PSNTSSSNNSYANSPLSPLTPNSTA 837
            .|..|                     ||..:||||:::| ||:.|||:.|.::||: |.:|:.:.
Mosquito   875 GTVDGAASLVSNAGTIAGINGSQTQQQHNYAPSSSASAASPSSLSSSSISVSSSPV-PSSPSRSH 938

  Fly   838 TASNPSHQQ----------------QQQHHNQQQQQQQQQQHHPQHHDNSNSSSNIDPLFNYREE 886
            .:|||:...                ..:.|:.........||        |::|| ||..|||:|
Mosquito   939 ISSNPNSPSGTSGLGSSASSTVSTVDGRRHSMTTIGSSNHQH--------NATSN-DPFINYRDE 994

  Fly   887 SNDTSCSQHLHSPSITSKSPEDSSLPSLCSPNSLTQEDDFSFEA-------FAMRAPYIPID--D 942
            .|:.|.|.||.||.| |||||.||||||||||....||:.:|.:       .:||||||.:.  |
Mosquito   995 VNEVSPSPHLLSPGI-SKSPESSSLPSLCSPNGSLPEDELAFMSLNMDELDLSMRAPYISMSEVD 1058

  Fly   943 DMPLLTETDLMWCPP------------------------EDLQTMVPKEIDAIQQQLQQLQQQHH 983
            |:||||..||:|..|                        :|..|.:....:..:.....|....
Mosquito  1059 DLPLLTSDDLLWGVPAAAIEGNATGTSISAFGLSGKFFIKDEFTAIGSAANGTETGSSSLADPS- 1122

  Fly   984 QQYAGNTGYQQQQQQPQLQQQH------FSNSLCSSPASTVSSLS------PSPVQQHHQQQQAA 1036
               |.:..:..|...| :.::|      ..:::.::.|.:|:..|      |:....::..:..|
Mosquito  1123 ---AASLPHTVQHSLP-VDKEHSLLLSAVVDTIAANDAGSVAGSSSGSSDLPATNNSNNDSKSTA 1183

  Fly  1037 VFTSDS-----SELAALLCGSGNGTLSILAGSGVTVAEECNERLQQHQQQQQQTSGNEFRTFQQL 1096
            ...:.|     |.|||||||          |:.:::..:.:      ...|||:.||     |.|
Mosquito  1184 PSAASSAASIDSSLAALLCG----------GNVISIQSDTS------NLSQQQSIGN-----QLL 1227

  Fly  1097 QQELQLQEEQQQRQQQQQQQQQ---QQQQQQLLSLN------IECKKEKYDVQMGGSLCHPMEDA 1152
            ........:|:||...|.|.||   ||||||..|||      .|...::..:.....|.|.|...
Mosquito  1228 ISHTNAGNQQEQRHNNQPQPQQSPLQQQQQQQSSLNGSQQRQQEAGPKRIKLSEHNLLPHSMVVL 1292

  Fly  1153 FENDYSKDSANL---DCW---DLIQMQ----VVDTEPVSPNAASPTPCKVSAIQLLQQQQQLQQQ 1207
                    .||:   |.|   ||:|:.    .::|:|.:.                |||||.||.
Mosquito  1293 --------PANVKLCDTWKFDDLLQLNGGSISINTKPGTQ----------------QQQQQQQQA 1333

  Fly  1208 QQQQQNIILNAVPLITIQNNKELMQQQQQQQQQQQQEQLQQPAIKLLNGASIAPVNTKATIRLVE 1272
            ...|.|||.:.|                       ...:::|:...:||      |.|.|:..|.
Mosquito  1334 IVPQTNIIASFV-----------------------TTAVKKPSPTGVNG------NNKRTLAGVS 1369

  Fly  1273 SKPPTTTQSRMAKVNLVPQQQQHGNKRHLNSATGAGNPVESKRLKSGTLCLDVQSPQLLQQLIGK 1337
            .....|...              .|.:.|.|::||| |..|             :|||||||:..
Mosquito  1370 ESADDTAAG--------------NNCKRLKSSSGAG-PAPS-------------APQLLQQLMAP 1406

  Fly  1338 DPAQQQTQAAKRAGSE-----RWQLS-AESKQQKQQQQQSNSVLKNLLVSGRDDD---------- 1386
            .|..|:.::..|:..:     ||... |.......|:|..||||.||||||.|..
Mosquito  1407 SPVPQKLKSKSRSAQDGGAGGRWPNGHAGGNAGLLQEQSGNSVLMNLLVSGCDKTIPLTPPEILI 1471

  Fly  1387 DSEAMI-IDEDNSLVQPIPLGKYGLPLHCHTSTSSVLRDYHNNPLISGTNFQLSPVFGGSDSSGG 1450
            ::..|: :..|.:..:|..|...|             .:..|..|.|.||    |:.||.
Mosquito  1472 ENTGMVELSSDGNTTRPDMLFNLG-------------DEDDNGVLFSSTN----PLIGGQ----- 1514

  Fly  1451 DGETGSVVSLDDSVPPGLTACDTDASSDSGIDENSLMDGASGSPRKRLSSTSNSTNQAESAPPAL 1515
                   ..|:|::...||           |........|||:.|              ...||
Mosquito  1515 -------APLNDALARPLT-----------IQTEQQHGTASGAER--------------GCTPA- 1546

  Fly  1516 DVETPVTQKSVEEEFEG-------GGSGSNAPSRKTSISFLDSSNPLLHTPAMMDL 1564
              :.|:          |       ||||::|.:|.:..|.|.|  |.|.||..:::
Mosquito  1547 --QGPI----------GGTPGKLFGGSGASATARNSQFSMLVS--PSLLTPTDLEI 1588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	39/56 (70%)
		PAS	256..392	CDD:395786	79/143 (55%)
		PAS	265..>317	CDD:238075	35/51 (69%)
		PAS	404..505	CDD:238075	67/100 (67%)
sima	XP_061502141.1	None