Protein Alignment sima and LOC1272364

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: XP_061517178.1
• Gene: LOC1272364 / 1272364
• VectorBaseID: AGAMI1_012456
• Length: 1168
• Species: Anopheles gambiae
• Alignment Length: 1167
• Identity: 266/1167 - (22%)
• Similarity: 405/1167 - (34%)
• Gaps: 449/1167 - (38%)

  Fly   160 KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCN 224
            ||||::|||.||.||...|:||:..|||.:...:||||||::|:|.::||:|.:  |...|.|..
Mosquito    12 KEKSKNAARSRREKENAEFLELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAV--FPEGLGDAW 74

  Fly   225 DDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSENVVEYL 289
            .  .|.|........:|   |:|:.           |.||:|||:.|::.:|.|.|:||....:|
Mosquito    75 G--TQHIPNNPRDLAIK---ELGSH-----------LLQTLDGFIFVVAPDGKIMYISETASVHL 123

  Fly   290 GITKIDTLGQQIWEYSHQCDHAEIKEALSLKRE-------------------------------- 322
            |:::::..|..|:||.|..|..|:...|||:..
Mosquito   124 GLSQVELTGNSIYEYIHNYDQDEMTSVLSLQPNMYVGPPAGGNGTEPSPGTGPLLASTPSHSSLA 188

  Fly   323 ------------------------------------------------------LAQKVKD---- 329
                                                                  |.|...|
Mosquito   189 ADAGGPTGTTDSPISPFASLLHHQHHHHHPGGGESPPQSLTSSGGSIGTTLGGPLGQSPNDMQAG 253

  Fly   330 -------EPQQNSGVS----------------------------THH------------------ 341
                   :.||:.|.:                            .||
Mosquito   254 MHHHQQQQQQQHMGGNGGHSPLGAVYGSGPGGYGGMPQPPHHHHNHHHGHYHHHHHHSYGQHQTI 318

  Fly   342 ---RDLFVRLKCTLTSRGRSINIKSASYKVIHITGHL--------VVNAKGERL-----LMAIGR 390
               |..|:|:||.|..  |:..:.::.|||||.:|:|        ....:|...     |:|:|.
Mosquito   319 EIERTFFLRMKCVLAK--RNAGLTTSGYKVIHCSGYLKARIYPGDATYGEGHSCIQNLGLVAVGH 381

  Fly   391 PIPHPSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMAT 455
            .:|..:..||.|..:.|:.:.|:|::..::|.|:..|.||.|:||::.:|:...|.||...:..:
Mosquito   382 SLPPSAITEIKLYQNMFMFRASMDLKLIFLDAKVAQLTGYEPQDLIEKTLYQYVHAADILHMRYS 446

  Fly   456 FKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLA 518
            .:.::.|||..|..||||.|.||:.|:.|.||:|::  ..:|..:|.||||:|:.|        |
Mosquito   447 HQVLMYKGQVTTKYYRFLTKGGGWAWVQSYATVVHNTRSSRPHCIVSVNYVLSDQE--------A 503

  Fly   519 QQTAASEQKEQHHQAAETEKEPEKAADPEI-------IAQETKETVNTPIHTSELQAKPLQLESE 576
            |....:|.::..| :|.|:.:|..:..||.       :|...|
Mosquito   504 QDLLLNEVQQPQH-SAPTQHQPSPSVKPEAGGGGGGGVAASNK---------------------- 545

  Fly   577 KAEKTIEE--TKTIATIPPVTATSTADQIKQLPESN-------------------PYKQILQAEL 620
              |:::.|  |...||:.||:..::.......|...                   |::..:...|
Mosquito   546 --ERSLSEPATALAATMTPVSGLASGVPAHMSPIGGTVVVGGNNGTARRGASVQPPHQASMSYGL 608

  Fly   621 LIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKS-------VTASVLRPSPAPPLTPPPTAVLC 678
            |.|...|               ...|:.::::.:.       ..|::...:...|:...|:|  |
Mosquito   609 LGKELQH---------------QDHLQQQQQQQQQHQHNTFLQLANLDDDASLGPIPGAPSA--C 656

  Fly   679 KKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLFADDGRGLTML 743
            ..|..| ...|||:|       .....:||:...:...:.|:| ...|.|:|...|..| ||.
Mosquito   657 LVTHPG-STGLPPST-------GQDEYELQMQYGSGTTHQQEP-NTGSTGYCMNAAPTG-GLL-- 709

  Fly   744 KEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQHYQSP-SS 807
              |......|..:......  :.|:.|...|            ..||.           |.| |.
Mosquito   710 --EGHGAGPHPGTDGSDAF--LEPYYDQFYG------------GYDSR-----------QDPISM 747

  Fly   808 SSTSAPSNTSSSNNSYANSPLSPLTPNSTATASNPSHQQQQQHHNQQQQQQQQQQHHPQHHDNSN 872
            ...||.||:.||  |.|...|              .||||   |:||...|||||||.||
Mosquito   748 RPYSASSNSCSS--SEAEGVL--------------GHQQQ---HHQQHHHQQQQQHHQQH----- 788

  Fly   873 SSSNIDPLFNYREESNDTSCSQHLHSPSITSKSPEDSSLPSLCSPNSLTQEDDFSFEAFAMRAPY 937
                  ||            .|....||..|.        |:.....|.|.
Mosquito   789 ------PL------------QQQPPPPSYGSM--------SMAGAGVLRQH-------------- 813

  Fly   938 IPIDDDMPLLTETDLMWCPPEDLQTMVPKEIDAIQQQLQQLQQQHHQ-QYAGNTGYQQQQ-QQPQ 1000
                     :|..|                       |......||| .:..:.|:|||| ...|
Mosquito   814 ---------VTTGD-----------------------LGNTYGDHHQLDFVPSNGHQQQQHHHHQ 846

  Fly  1001 LQQ--QHFSNS--------LCSSPAS---TVSSLSP-----SPVQQHH---------QQQQA--- 1035
            |||  ||..::        ..:|||:   :.||.||     .|.:.||         |||.|
Mosquito   847 LQQLDQHTGHTNGGNSSFLYDASPATMDGSTSSASPFDGIAQPFELHHLPTTHGHFRQQQHADLQ 911

  Fly  1036 -------AVFTSDSSELAALLCGS------GNGTLSILAGSGVTVAEECNERLQQHQQQQQQ 1084
                   .|.::.||..:|||.||      .:...|:::|:....:::  .:|..|.|.|.|
Mosquito   912 QQLGESPLVSSTSSSSSSALLGGSPARRPAPDRDESVVSGAEPGASKQ--PKLANHHQHQHQ 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	28/55 (51%)
		PAS	256..392	CDD:395786	50/294 (17%)
		PAS	265..>317	CDD:238075	18/51 (35%)
		PAS	404..505	CDD:238075	36/102 (35%)
LOC1272364	XP_061517178.1	None