Protein Alignment sima and Arnt2

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_031514.3
• Gene: Arnt2 / 11864
• MGIID: 107188
• Length: 712
• Species: Mus musculus
• Alignment Length: 796
• Identity: 170/796 - (21%)
• Similarity: 272/796 - (34%)
• Gaps: 251/796 - (31%)

  Fly   149 DIEDFMNNEK-RKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIRE 212
            |.||.....| .:|...:..|.||:|.|:...|||..:|..:....:.||.:::|:.::.:|
Mouse    53 DDEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK--- 114

  Fly   213 MLQFVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHE-G 276
                  |:|...:        .......||       .:|...|.:.|:.:..||||.|::.| |
Mouse   115 ------SMRGTGN--------KSTDGAYKP-------SFLTEQELKHLILEAADGFLFVVAAETG 158

  Fly   277 DITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLK------RELAQK---VKDEPQ 332
            .:.|||::|...|...:.:..|..::|..|..|..:::|.|...      |.|..|   ||.|.|
Mouse   159 RVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQ 223

  Fly   333 QNS-----GVSTHHRDLFVRLKC--------------TLTSRGRS----INIKSASYKVIHITGH 374
            |:|     |   ..|....|::|              |:..|.|:    :....|.|.|:|.||:
Mouse   224 QSSMRMCMG---SRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGY 285

  Fly   375 LV---------------VNAKGERLLMAIGR------PI-PHPSNIEIPLGTSTFLTKHSLDMRF 417
            :.               |....:..|:||||      |: ...|.:.:|   :.||::|:.|...
Mouse   286 IKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMSGMSVP---TEFLSRHNSDGII 347

  Fly   418 TYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLS-KGQGETSRYRFLGKYGGYCW 481
            |:||.:...::||.|:|||...:....|..|...|..:|:.|:. |||..:..|||..|  ...|
Mouse   348 TFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTK--NREW 410

  Fly   482 ILSQATIVYDKLKPQS-----VVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAETEKEPE 541
            :|.: |..:....|.|     |:|.|                     :..|:...|.||.|....
Mouse   411 LLIR-TSSFTFQNPYSDEIEYVICTN---------------------TNVKQLQQQQAELEVHQR 453

  Fly   542 KAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTATSTADQIKQL 606
            .......::|.....:...:|              :|.|::|
Mouse   454 DGLSSYDLSQVPVPNLPAGVH--------------EAGKSVE----------------------- 481

  Fly   607 PESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTP 671
                      :|:.:..:|.   .||  .|::.:|.|:.   |:|...|.:||.
Mouse   482 ----------KADAIFSQER---DPR--FAEMFAGISAS---EKKMMSSASASG----------- 517

  Fly   672 PPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLF--- 733
                                                  :||...|....||....|.|.|..
Mouse   518 --------------------------------------SQQIYSQGSPFPAGHSGKAFSSSVVHV 544

  Fly   734 --ADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTT 796
              .:|.:..:...:....:|..|............||             |...:...|:.....
Mouse   545 PGVNDIQSSSSTGQNISQISRQLNQGQVAWTGSRPPF-------------PGQPSKTQSSAFGIG 596

  Fly   797 ASGQHYQSPSS-SSTSAPSNTSSSNNSYANSPLSPLTPNSTATASN-------PSH---QQQQQH 850
            :|..:...||| |..|:|:.:|.|.|:|.:  |:..||....:..:       ||.   |.|.||
Mouse   597 SSHPYPADPSSYSPLSSPAASSPSGNAYPS--LANRTPGFAESGQSGGQFQGRPSEVWSQWQSQH 659

  Fly   851 HNQQQQQQQQQQHHPQ 866
            |.||..:|...|...|
Mouse   660 HGQQSGEQHSHQQPGQ 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	14/56 (25%)
		PAS	256..392	CDD:395786	48/189 (25%)
		PAS	265..>317	CDD:238075	17/52 (33%)
		PAS	404..505	CDD:238075	33/106 (31%)
Arnt2	NP_031514.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..73		5/19 (26%)
		bHLH-PAS_ARNT	62..124	CDD:381517	17/78 (22%)
		PAS	137..243	CDD:395786	32/108 (30%)
		PAS_11	336..436	CDD:464214	33/123 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	573..712		30/118 (25%)