DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sima and sim2

DIOPT Version :9

Sequence 1:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster
Sequence 2:	XP_031752412.1	Gene:	sim2 / 100492082	XenbaseID:	XB-GENE-1013958	Length:	761	Species:	Xenopus tropicalis

Alignment Length:	995	Identity:	225/995 - (22%)
Similarity:	374/995 - (37%)	Gaps:	316/995 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCN 224
            ||||::||:.||.||...|.||:..|||.:...:||||||::|:|.::||:|.:  |...|.|.
Frog     2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAV--FPDGLGDA- 63

  Fly   225 DDIKQDIETAEDQQEVKPKLEVGTEDWLNGAE-------AREL---LKQTMDGFLLVLSHEGDIT 279
                                      |.:.:.       |:||   |.||:|||:.|::.:|.|.
Frog    64 --------------------------WGHPSRMGPLDNVAKELGSHLLQTLDGFVFVVASDGKIM 102

  Fly   280 YVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALS----LKRELAQKVKDEPQQNSGVSTH 340
            |:||....:||:::::..|..|:||.|..||.|:...|:    |...|.|:.:.|
Frog   103 YISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHPHLLQEYEIE---------- 157

  Fly   341 HRDLFVRLKCTLTSRGRSINIKSASYKVIHITGHLVVNAKGERL-----------LMAIGRPIPH 394
             |..|:|:||.|..  |:..:..:.|||||.:|:|.:......:           |:|:|:.:|.
Frog   158 -RSFFLRMKCVLAK--RNAGLTCSGYKVIHCSGYLKIRQYMLDISLYDSCYQIVGLVAVGQSLPP 219

  Fly   395 PSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSV 459
            .:..||.|.::.|:.:.|||::..::|.::.:|.||.|:||::.:|:...||.|...|..:...:
Frog   220 SAITEIKLHSNMFMFRASLDLKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDVFHLRYSHHLL 284

  Fly   460 LSKGQGETSRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTA 522
            |.|||..|..||.|.|.||:.|:.|.||||::  ..:|..:|.||||::::|.|....||.|.|.
Frog   285 LVKGQVTTKYYRLLSKNGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDVEYKELQLSLEQVTV 349

  Fly   523 ASEQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKT 587
            :              |.|              .:..||:.||:...||::::|.|
Frog   350 S--------------KVP--------------FSCRTPMTTSQEARKPIKVKSGK---------- 376

  Fly   588 IATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRE-------NHSPGPRTITAQLLSGSSSG 645
                           :|..|.:|||.|...:.:..|.:       ..||...|.|.|
Frog   377 ---------------VKSKPRANPYPQPYTSFIGDKLDCSQYGSWKGSPTINTATNQ-------- 418

  Fly   646 LRPEEKRPKSVTASVLRPSPAPPLT------PPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSN 704
               |:......:..:..|:.:.|..      |..:.||..|..:.......|.:::...:.....
Frog   419 ---EQSNHSENSELLYTPTYSLPFPYHYGHFPMDSHVLSSKKQVVPSRYGQPQSSSPCEVARFFF 480

  Fly   705 QQLQIAQQTQLQ--------NPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQ 761
            ..||...:....        :|.:...|.|                :.:...:|:|:..:..
Frog   481 STLQTGGECHWHYTNSVVPGSPPKNIHDQS----------------VNQARHNLAHNYEAAT--- 526

  Fly   762 LDEMTPFSDMLVGLMGTCLLPEDINSLDS-----TTCSTTASGQHYQSPSSSSTSAPSNTSSSNN 821
                                 :..::|||     |.||...|...|:  .....|||..|:.|.|
Frog   527 ---------------------KKFSALDSPPDGFTDCSMPRSSARYK--DELYHSAPMKTNKSEN 568

  Fly   822 SYANSPLSPLTPNSTATASNPSHQQQQQHH-NQQQQQQQQQQHHPQHHDNSNSSSNIDPLFNYRE 885
                            .|:.|.|..::::. :..:.||::...:.:|..||.|:|.:..
Frog   569 ----------------RAAPPYHGVKEENKLSFSRYQQEKTFANEKHFPNSLSNSVLQK------ 611

  Fly   886 ESNDTSCSQHLHSPSITSKSPEDSSLP---------SLCSPNSLTQEDDFSFEAFAMRAPYIPID 941
                   |:.||:.:|...|   ..||         .||     .:|..:|...| ..:.|..:|
Frog   612 -------SECLHAKTIGQLS---HLLPRPVVYEQTRRLC-----MKEPRYSHPTF-HHSGYNELD 660

  Fly   942 DDMPLLTETDLMWCPPEDLQTMVPKEIDAIQQQLQQLQQQHHQQYAGNTGYQQQQQQPQLQQQHF 1006
            :|     .|:..:.                          ||..                :.:||
Frog   661 ND-----RTNSRFA--------------------------HHNS----------------EHEHF 678

  Fly  1007 SNSLCSSPASTVSSLSPSPVQQHHQQQQAAVFTSDSSELAALLCGSGNGTLSILAGSGVTVAEEC 1071
                  .|...|..:   |:..||      |.:...:...:...|:.:||.....||     ||.
Frog   679 ------KPGGQVPYV---PLNYHH------VLSKHGTCQTSPCTGTDHGTEHYGYGS-----EEV 723

  Fly  1072 NERLQQHQQQQQQTSGNEFR 1091
            |..:.::|.....:|....|
Frog   724 NSFVYKNQSPSSVSSPETHR 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	24/48 (50%)
		PAS	256..392	CDD:279347	47/160 (29%)
		PAS	265..>317	CDD:238075	19/51 (37%)
		PAS	404..505	CDD:238075	38/102 (37%)
		PAS_3	417..502	CDD:285623	31/86 (36%)
sim2	XP_031752412.1	bHLH-PAS_SIM2	1..74	CDD:381582	31/100 (31%)
		PAS	88..>158	CDD:238075	24/80 (30%)
		PAS_3	243..329	CDD:369881	31/85 (36%)
		SIM_C	359..636	CDD:399545	65/386 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000