Protein Alignment sima and sim1

DIOPT Version :9

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: XP_004914602.1
• Gene: sim1 / 100486719
• XenbaseID: XB-GENE-485816
• Length: 763
• Species: Xenopus tropicalis
• Alignment Length: 1000
• Identity: 221/1000 - (22%)
• Similarity: 347/1000 - (34%)
• Gaps: 370/1000 - (37%)

  Fly   160 KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCN 224
            ||||::|||.||.||...|.||:..|||.:...:||||||::|:|.::||:|  :.|...|
 Frog     2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMR--VVFPEGL---- 60

  Fly   225 DDIKQDIETAEDQQEVKPKLEVGTEDWLN----------GAEARELLKQTMDGFLLVLSHEGDIT 279
                                   .|.|.:          |.|....|.||:|||:.|::.:|.|.
 Frog    61 -----------------------GEAWGHTSRPSTLDNVGRELGSHLLQTLDGFIFVVAPDGKIM 102

  Fly   280 YVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTH--HR 342
            |:||....:||:::::..|..|:||.|..||.|:...|:         ..:|..:..|..:  .|
 Frog   103 YISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT---------AHQPYHSHFVQEYEIER 158

  Fly   343 DLFVRLKCTLTSRGRSINIKSASYKVIHITGHLVVNAKGERL-----------LMAIGRPIPHPS 396
            ..|:|:||.|..  |:..:....|||||.:|:|.:......:           |:|:|..:|..:
 Frog   159 SFFLRMKCVLAK--RNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSA 221

  Fly   397 NIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLS 461
            ..||.|.::.|:.:.||||:..::|.::.:|.||.|:||::.:|:...||.|:..|......:|.
 Frog   222 VTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLV 286

  Fly   462 KGQGETSRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAAS 524
            |||..|..||||.|:||:.|:.|.||||::  ..:|..:|.||||:::.|.|....||.|.|
 Frog   287 KGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQVT--- 348

  Fly   525 EQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKT-IEETKTI 588
                               ..|......:..|:|               :|.|:.|. :..||:.
 Frog   349 -------------------TKPPFSYTSSNPTIN---------------DSRKSSKARLSNTKSK 379

  Fly   589 ATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGL---RPEE 650
            :                  .::||.|.                            ||.   |.|.
 Frog   380 S------------------RTSPYPQY----------------------------SGFHTERSES 398

  Fly   651 KRPKSVTASVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQL 715
            ........|.|..:.:|.|..|                                          :
 Frog   399 DHESQWGGSPLTDTASPQLLDP------------------------------------------I 421

  Fly   716 QNPQQPAQDMS---------KGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDM 771
            :.|.....|:|         .|.|..|:.|...|:      ||..||  |.:|..
 Frog   422 ERPSSHQHDVSCAYRQYPDRSGLCFGFSIDHSRLS------DDRHHH--SQSCEG---------- 468

  Fly   772 LVGLMGTC----------------------LLPEDINSLD-----STTCSTTASG------QHYQ 803
                 |.|                      :||....|.|     ..|....|||      .|::
 Frog   469 -----GRCEAGRYFLGSPQTGRETWWGSRSVLPVPKTSPDGKDIYEATMPHIASGHRAHGRSHWE 528

  Fly   804 SPSSSSTSAPSNTSSS-----NNSYANSPLSPLTPNSTATASNPSHQQQQQHHNQQQQQQQQQQH 863
            ..|..|:..|.:.|.|     .:.|.||...|....:...|:       ||...:::.:.|.::.
 Frog   529 EDSVVSSPDPGSASESGDRYRTDQYQNSHHEPSKIETLIRAT-------QQMIKEEESRIQLRKP 586

  Fly   864 HPQHHDNSNSSSNIDPLFNYREESNDTSCSQHLHSPSITSKSPEDSSLPSLCSPNSLTQEDDFSF 928
            .|......|.:.           ..::.|..:.|.|.:|.         .:|
 Frog   587 SPDQLTTINGAG-----------KRNSVCFANFHQPQLTG---------VVC------------- 618

  Fly   929 EAFAMRAPYIPIDDDMPLLTETDLMWCPPEDLQTMVPKEIDAIQQQLQQLQQQHHQQYAGNTGYQ 993
                 |.|  |:.:..|         |             |.:||:..::......:|..:....
 Frog   619 -----RGP--PLSNSSP---------C-------------DHVQQRDGKILSPRDHEYENSPNAL 654

  Fly   994 QQQQQPQLQQQHFSNSLCSSPASTV------SSLSPSPVQQH---------HQQ---QQAAVFT- 1039
            .:...|       ::...|..:.|:      ::|||||...|         |:|   :....||
 Frog   655 SRMSSP-------NSDRVSKSSVTIAKDYLHANLSPSPAMDHSASPNYYSSHRQYFDKHTYTFTG 712

  Fly  1040 --------SDSSELAALLCGSGNGT 1056
                    |:|....:|.|   |||
 Frog   713 YALEHLYDSESIRNYSLGC---NGT 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	25/48 (52%)
		PAS	256..392	CDD:279347	43/148 (29%)
		PAS	265..>317	CDD:238075	19/51 (37%)
		PAS	404..505	CDD:238075	40/102 (39%)
		PAS_3	417..502	CDD:285623	32/86 (37%)
sim1	XP_004914602.1	bHLH-PAS_SIM1	1..71	CDD:381581	32/97 (33%)
		PAS	88..>158	CDD:238075	22/78 (28%)
		PAS_3	243..329	CDD:369881	32/85 (38%)
		SIM_C	358..668	CDD:369005	75/511 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910