DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-A and Dmc1

DIOPT Version :9

Sequence 1:	NP_524583.1	Gene:	spn-A / 43577	FlyBaseID:	FBgn0003479	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001124039.1	Gene:	Dmc1 / 362960	RGDID:	1307611	Length:	340	Species:	Rattus norvegicus

Alignment Length:	337	Identity:	171/337 - (50%)
Similarity:	221/337 - (65%)	Gaps:	10/337 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QAQQEE---EEEEGPL--SVTKLIGGSITAKDIKLLQQASLHTVESVANATKKQLMAIPGLGGGK 67
            |..|||   ::||..|  .:..|....|...|||.|:...:.|::.:...|::.|..:.||...|
  Rat     5 QVVQEESGFQDEEESLFQDIDLLQKHGINMADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAK 69

  Fly    68 VEQIITEANKLVPLGFLSARTFYQMRADVVQLSTGSKELDKLLGGGIETGSITEIFGEFRCGKTQ 132
            ||:|...||||:..|||:|..:.:.|..|..::|||:|.|||||||||:.:|||.|||||.||||
  Rat    70 VEKIKEAANKLIEPGFLTAFQYSEKRKMVFHITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQ 134

  Fly   133 LCHTLAVTCQLPISQKGGEGKCMYIDTENTFRPERLAAIAQRYKLNESEVLDNVAFTRAHNSDQQ 197
            |.|||.||.|||.:.....||.::|||||||||:||..||.|:.::...|||||.:.||:.|:.|
  Rat   135 LSHTLCVTAQLPGADGYSGGKIIFIDTENTFRPDRLRDIADRFNVDHDAVLDNVLYARAYTSEHQ 199

  Fly   198 TKLIQMAAGMLFESR--YALLIVDSAMALYRSDYIGRGELAARQNHLGLFLRMLQRLADEFGVAV 260
            .:|:...|....|..  :.||||||.|||:|.|:.||||||.||..|...|..||::::|:.|||
  Rat   200 MELLDYVAAKFHEEAGIFKLLIVDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVAV 264

  Fly   261 VITNQVTASLDGAPGMF--DAKKPIGGHIMAHSSTTRLYLRKGKGETRICKIYDSPCLPESEAMF 323
            .:|||:||. .||...|  |.||||||||:||:||||:.||||:||.||.||||||.:||:||.|
  Rat   265 FVTNQMTAD-PGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATF 328

  Fly   324 AILPDGIGDARE 335
            ||...|||||:|
  Rat   329 AITTGGIGDAKE 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-A	NP_524583.1	recomb_RAD51	22..335	CDD:274048	163/316 (52%)
		HHH_5	30..77	CDD:291205	15/46 (33%)
		Rad51_DMC1_radA	99..331	CDD:238543	134/235 (57%)
Dmc1	NP_001124039.1	recomb_DMC1	24..338	CDD:131292	161/314 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0468
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62165
OrthoDB	1	1.010	-	-		D357659at33208
OrthoFinder	1	1.000	-	-		FOG0001571
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100483
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730