DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-A and rhp51

DIOPT Version :9

Sequence 1:	NP_524583.1	Gene:	spn-A / 43577	FlyBaseID:	FBgn0003479	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_593882.1	Gene:	rhp51 / 2543580	PomBaseID:	SPAC644.14c	Length:	365	Species:	Schizosaccharomyces pombe

Alignment Length:	346	Identity:	209/346 - (60%)
Similarity:	263/346 - (76%)	Gaps:	11/346 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEKLTNVQAQ---------QEEEEE--EGPLSVTKLIGGSITAKDIKLLQQASLHTVESVANATK 54
            |....|.|||         |:||:|  .||:.:..|.|..|||.|||.:.:|..:||||:|...|
pombe    15 MNNNENGQAQSNYEYDVNVQDEEDEAAAGPMPLQMLEGNGITASDIKKIHEAGYYTVESIAYTPK 79

  Fly    55 KQLMAIPGLGGGKVEQIITEANKLVPLGFLSARTFYQMRADVVQLSTGSKELDKLLGGGIETGSI 119
            :||:.|.|:...|.::::.||:||||:||.:|..::..|::::.::||||:||.||.||:|||||
pombe    80 RQLLLIKGISEAKADKLLGEASKLVPMGFTTATEYHIRRSELITITTGSKQLDTLLQGGVETGSI 144

  Fly   120 TEIFGEFRCGKTQLCHTLAVTCQLPISQKGGEGKCMYIDTENTFRPERLAAIAQRYKLNESEVLD 184
            ||:|||||.||:|:||||||||||||...||||||:|||||.||||.||.|:|.||.||..||||
pombe   145 TELFGEFRTGKSQICHTLAVTCQLPIDMGGGEGKCLYIDTEGTFRPVRLLAVADRYGLNGEEVLD 209

  Fly   185 NVAFTRAHNSDQQTKLIQMAAGMLFESRYALLIVDSAMALYRSDYIGRGELAARQNHLGLFLRML 249
            |||:.||:|:|.|.:|:|.||.|:.|||::||:|||..||||:|:.|||||:|||.||..|:|.|
pombe   210 NVAYARAYNADHQLELLQQAANMMSESRFSLLVVDSCTALYRTDFSGRGELSARQMHLARFMRTL 274

  Fly   250 QRLADEFGVAVVITNQVTASLDGAPGMFDAKKPIGGHIMAHSSTTRLYLRKGKGETRICKIYDSP 314
            ||||||||:||||||||.|.:||.....|.||||||:|:||||||||.||||:||.|||||||||
pombe   275 QRLADEFGIAVVITNQVVAQVDGISFNPDPKKPIGGNILAHSSTTRLSLRKGRGEQRICKIYDSP 339

  Fly   315 CLPESEAMFAILPDGIGDARE 335
            |||||||:|||..||:||.:|
pombe   340 CLPESEAIFAINSDGVGDPKE 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-A	NP_524583.1	recomb_RAD51	22..335	CDD:274048	197/312 (63%)
		HHH_5	30..77	CDD:291205	20/46 (43%)
		Rad51_DMC1_radA	99..331	CDD:238543	165/231 (71%)
rhp51	NP_593882.1	recomb_RAD51	47..360	CDD:274048	197/312 (63%)
		HHH_5	53..102	CDD:291205	20/48 (42%)
		Rad51_DMC1_radA	124..356	CDD:238543	165/231 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	353	1.000	Domainoid score	I167
eggNOG	1	0.900	-	-		E1_COG0468
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2155
Inparanoid	1	1.050	415	1.000	Inparanoid score	I355
OMA	1	1.010	-	-		QHG62165
OrthoFinder	1	1.000	-	-		FOG0001571
OrthoInspector	1	1.000	-	-		oto100786
orthoMCL	1	0.900	-	-		OOG6_100483
Panther	1	1.100	-	-	LDO	PTHR22942
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1063
SonicParanoid	1	1.000	-	-		X3765
TreeFam	1	0.960	-	-
	14	13.860