DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-A and rad-51

DIOPT Version :9

Sequence 1:	NP_524583.1	Gene:	spn-A / 43577	FlyBaseID:	FBgn0003479	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001023465.1	Gene:	rad-51 / 177914	WormBaseID:	WBGene00004297	Length:	395	Species:	Caenorhabditis elegans

Alignment Length:	324	Identity:	181/324 - (55%)
Similarity:	234/324 - (72%)	Gaps:	2/324 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EEEEGPLSVTKLIGGSITAKDIKLLQQASLHTVESVANATKKQLMAIPGLGGGKVEQIITEANKL 78
            |::|....:.||....|::.||..|::|..:|.||:|..|:::|..:.|:...|.|:|:.||.|.
Worm    71 EQDENFTVIDKLESSGISSGDISKLKEAGYYTYESLAFTTRRELRNVKGISDQKAEKIMKEAMKF 135

  Fly    79 VPLGFLSARTFYQMRADVVQLSTGSKELDKLLGGGIETGSITEIFGEFRCGKTQLCHTLAVTCQL 143
            |.:||.:....:..|:.:||:.|||..||:|||||||||||||::||:|.|||||||:|||.|||
Worm   136 VQMGFTTGAEVHVKRSQLVQIRTGSASLDRLLGGGIETGSITEVYGEYRTGKTQLCHSLAVLCQL 200

  Fly   144 PISQKGGEGKCMYIDTENTFRPERLAAIAQRYKLNESEVLDNVAFTRAHNSDQQTKLIQMAAGML 208
            ||...|||||||||||..||||||:.||||||.::.:.||:|:|..||:||:....||..|..|:
Worm   201 PIDMGGGEGKCMYIDTNATFRPERIIAIAQRYNMDSAHVLENIAVARAYNSEHLMALIIRAGAMM 265

  Fly   209 FESRYALLIVDSAMALYRSDYIGRGELAARQNHLGLFLRMLQRLADEFGVAVVITNQVTASLDGA 273
            .|||||::|||.|.|.:|::|.|||:||.||..|..||:.|.:||||:||||:|||||.|.:||.
Worm   266 SESRYAVVIVDCATAHFRNEYTGRGDLAERQMKLSAFLKCLAKLADEYGVAVIITNQVVAQVDGG 330

  Fly   274 PGMF--DAKKPIGGHIMAHSSTTRLYLRKGKGETRICKIYDSPCLPESEAMFAILPDGIGDARE 335
            ..||  ||||||||||:||.|||||||||||||.|:.|:..||.|||:||.::|...||.||||
Worm   331 ASMFQADAKKPIGGHIIAHMSTTRLYLRKGKGENRVAKMVQSPNLPEAEATYSITNHGIEDARE 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-A	NP_524583.1	recomb_RAD51	22..335	CDD:274048	177/314 (56%)
		HHH_5	30..77	CDD:291205	17/46 (37%)
		Rad51_DMC1_radA	99..331	CDD:238543	148/233 (64%)
rad-51	NP_001023465.1	PTZ00035	62..394	CDD:185407	179/322 (56%)
		HHH_5	<94..132	CDD:291205	12/37 (32%)
		Rad51_DMC1_radA	156..390	CDD:238543	148/233 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162509
Domainoid	1	1.000	310	1.000	Domainoid score	I721
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2155
Inparanoid	1	1.050	355	1.000	Inparanoid score	I1308
Isobase	1	0.950	-	0	Normalized mean entropy	S193
OMA	1	1.010	-	-		QHG62165
OrthoDB	1	1.010	-	-		D357659at33208
OrthoFinder	1	1.000	-	-		FOG0001571
OrthoInspector	1	1.000	-	-		oto18124
orthoMCL	1	0.900	-	-		OOG6_100483
Panther	1	1.100	-	-	LDO	PTHR22942
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1063
SonicParanoid	1	1.000	-	-		X3765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890