DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7943 and SLC25A51

DIOPT Version :9

Sequence 1:	NP_651766.1	Gene:	CG7943 / 43574	FlyBaseID:	FBgn0039741	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	NP_219480.1	Gene:	SLC25A51 / 92014	HGNCID:	23323	Length:	297	Species:	Homo sapiens

Alignment Length:	305	Identity:	126/305 - (41%)
Similarity:	181/305 - (59%)	Gaps:	18/305 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PPKRFPSGRAHSPHGDGEAGKLLHGSVFSKRFFGSFQWEEFACGCGAAFVNIAVTYPIYKMIFRQ 81
            ||....|.:..||| ....|::.|                :.|||.|||.|:|:|:||.|::|||
Human    11 PPILTSSKQDISPH-ITNVGEMKH----------------YLCGCCAAFNNVAITFPIQKVLFRQ 58

  Fly    82 MLHGVPITSAFAQLRHEGLGFLYRGMLPPLAQKTISLSIMFGVFDGTRRYLVEDYRLNDYGAKVL 146
            .|:|:....|..|||.:|...||||:||||.|||.:|::|||:::.....|.:.....::....:
Human    59 QLYGIKTRDAILQLRRDGFRNLYRGILPPLMQKTTTLALMFGLYEDLSCLLHKHVSAPEFATSGV 123

  Fly   147 AAVVAGSAESILLPFERVQTLLADSKFHQHFSNTQNAFRYVVSHHGYRELYRGLEPVFWRNGLSN 211
            |||:||:.|:|..|.|||||||.|.|.|..|:||..||: .:..||..|.||||.|:.:||||||
Human   124 AAVLAGTTEAIFTPLERVQTLLQDHKHHDKFTNTYQAFK-ALKCHGIGEYYRGLVPILFRNGLSN 187

  Fly   212 ALFFVLREEASVRLPKRKSVSTRTVQEFIAGAVIGASISTIFYPLNVIKVSLQSEMGQRSEGSWQ 276
            .|||.||......||...:.|...|.:||.|.::||.:..:|:|:||:|..:||::|...:...:
Human   188 VLFFGLRGPIKEHLPTATTHSAHLVNDFICGGLLGAMLGFLFFPINVVKTRIQSQIGGEFQSFPK 252

  Fly   277 ACKRIYVERDRRIGNFYRGCPFNTGRSFISWGIMNTAYENLKKLM 321
            ..::|::||||::.|.:||...|..||.|||||:|..||.|.|::
Human   253 VFQKIWLERDRKLINLFRGAHLNYHRSLISWGIINATYEFLLKVI 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7943	NP_651766.1	Mito_carr	54..136	CDD:278578	38/81 (47%)
		Mito_carr	141..229	CDD:278578	44/87 (51%)
		Mito_carr	235..322	CDD:278578	35/87 (40%)
SLC25A51	NP_219480.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		3/8 (38%)
		Solcar 1. /evidence=ECO:0000255	28..108		39/95 (41%)
		Mito_carr	31..112	CDD:395101	39/96 (41%)
		Solcar 2. /evidence=ECO:0000255	116..200		42/84 (50%)
		Mito_carr	210..297	CDD:395101	35/86 (41%)
		Solcar 3. /evidence=ECO:0000255	213..296		33/82 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I7940
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H88487
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3370
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59392
OrthoDB	1	1.010	-	-		D503015at33208
OrthoFinder	1	1.000	-	-		FOG0004171
OrthoInspector	1	1.000	-	-		otm41713
orthoMCL	1	0.900	-	-		OOG6_107186
Panther	1	1.100	-	-	LDO	PTHR46131
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3422
SonicParanoid	1	1.000	-	-		X4548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	13.010