DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-delta and ZNF160

DIOPT Version :9

Sequence 1:	NP_524581.1	Gene:	Sry-delta / 43572	FlyBaseID:	FBgn0003512	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001096073.1	Gene:	ZNF160 / 90338	HGNCID:	12948	Length:	818	Species:	Homo sapiens

Alignment Length:	266	Identity:	69/266 - (25%)
Similarity:	103/266 - (38%)	Gaps:	47/266 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 DRPTKKRVKQECTTCGKVYNSWYQLQKH------------------ISEE---------HSKQPN 222
            ::|.|      |..||||:....||.:|                  .|:.         |:.:..
Human   562 EKPYK------CNECGKVFAQTSQLARHWRVHTGEKPYKCNDCGRAFSDRSSLTFHQAIHTGEKP 620

  Fly   223 HICPICGVIRRDEEYLELHMNLHEGKTEKQCRYCPKSFSRPVNTLRHMRMHWDKKKYQCEKCGLR 287
            :.|..||.:.|...||..|..:|.|:...:|..|.|:||...|...|..:|..:|.|:|.:||..
Human   621 YKCHECGKVFRHNSYLATHRRIHTGEKPYKCNECGKAFSMHSNLTTHKVIHTGEKPYKCNQCGKV 685

  Fly   288 FSQDNLLYNHRLRHEAEENPIICSICNVSFKSRKTFNHHTLIHKENRPRHYCSVCPKSFTERYTL 352
            |:|::.|.||:..|..|: |..|:.|..:|..|.:...|..||...:| :.|:.|.|.||:...|
Human   686 FTQNSHLANHQRTHTGEK-PYRCNECGKAFSVRSSLTTHQAIHTGKKP-YKCNECGKVFTQNAHL 748

  Fly   353 KMHMKTHEGDVVYGVREEAPADEQQVVEELHVDVDESEAAVTVIMSDNDENSGFCLICNTNFENK 417
            ..|.:.|.|:..|...|...|...:.....|:.:...|....            |..|...|...
Human   749 ANHRRIHTGEKPYRCTECGKAFRVRSSLTTHMAIHTGEKRYK------------CNECGKVFRQS 801

  Fly   418 KELEHH 423
            ..|..|
Human   802 SNLASH 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-delta	NP_524581.1	COG5048	<205..360	CDD:227381	50/181 (28%)
		C2H2 Zn finger	225..245	CDD:275368	7/19 (37%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		C2H2 Zn finger	281..301	CDD:275368	8/19 (42%)
		C2H2 Zn finger	310..327	CDD:275370	4/16 (25%)
		zf-C2H2	337..359	CDD:278523	7/21 (33%)
		C2H2 Zn finger	339..359	CDD:275368	7/19 (37%)
ZNF160	NP_001096073.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		zf-C2H2	257..279	CDD:278523
		C2H2 Zn finger	259..279	CDD:275368
		zf-H2C2_2	271..295	CDD:290200
		C2H2 Zn finger	287..307	CDD:275368
		zf-H2C2_2	299..324	CDD:290200
		C2H2 Zn finger	315..335	CDD:275368
		zf-H2C2_2	327..350	CDD:290200
		C2H2 Zn finger	343..363	CDD:275368
		zf-H2C2_2	355..380	CDD:290200
		COG5048	367..810	CDD:227381	69/266 (26%)
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..419	CDD:275368
		zf-H2C2_2	411..436	CDD:290200
		C2H2 Zn finger	427..447	CDD:275368
		zf-H2C2_2	439..463	CDD:290200
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	483..503	CDD:275368
		zf-H2C2_2	496..519	CDD:290200
		C2H2 Zn finger	511..531	CDD:275368
		zf-H2C2_2	523..548	CDD:290200
		C2H2 Zn finger	539..559	CDD:275368
		zf-H2C2_2	551..576	CDD:290200	7/19 (37%)
		C2H2 Zn finger	567..587	CDD:275368	8/19 (42%)
		C2H2 Zn finger	595..615	CDD:275368	1/19 (5%)
		zf-H2C2_2	607..632	CDD:290200	4/24 (17%)
		C2H2 Zn finger	623..643	CDD:275368	7/19 (37%)
		zf-H2C2_2	635..659	CDD:290200	8/23 (35%)
		C2H2 Zn finger	651..671	CDD:275368	7/19 (37%)
		zf-H2C2_2	663..688	CDD:290200	9/24 (38%)
		C2H2 Zn finger	679..699	CDD:275368	8/19 (42%)
		zf-H2C2_2	691..715	CDD:290200	8/24 (33%)
		C2H2 Zn finger	707..727	CDD:275368	5/19 (26%)
		zf-H2C2_2	719..744	CDD:290200	8/25 (32%)
		C2H2 Zn finger	735..755	CDD:275368	7/19 (37%)
		zf-H2C2_2	747..770	CDD:290200	6/22 (27%)
		C2H2 Zn finger	763..783	CDD:275368	3/19 (16%)
		zf-H2C2_2	775..800	CDD:290200	5/36 (14%)
		C2H2 Zn finger	791..811	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142346
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930