DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-delta and ZNF347

DIOPT Version :9

Sequence 1:	NP_524581.1	Gene:	Sry-delta / 43572	FlyBaseID:	FBgn0003512	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001166145.1	Gene:	ZNF347 / 84671	HGNCID:	16447	Length:	840	Species:	Homo sapiens

Alignment Length:	247	Identity:	67/247 - (27%)
Similarity:	102/247 - (41%)	Gaps:	44/247 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 FICEDVDVGDSEALYGKSSDGE-----DRPTKKRVKQECTTCGKVYNSWYQLQKHISEEHSKQPN 222
            ::|.  :.|.:.::|...:..:     ::|.|      |..||||:.....|.:|......::|
Human   542 YMCN--ECGKAFSVYSSLTTHQVIHTGEKPYK------CNECGKVFTQNSHLARHRGIHTGEKP- 597

  Fly   223 HICPICGVIRRDEEYLELHMNLHEGKT--------------------------EK--QCRYCPKS 259
            :.|..||.:.|...||..|..:|.|:.                          ||  :|..|.|.
Human   598 YKCNECGKVFRHNSYLSRHQRIHTGEKPYKYNEYGKAFSEHSNLTTHQVIHTGEKPYKCNECGKV 662

  Fly   260 FSRPVNTLRHMRMHWDKKKYQCEKCGLRFSQDNLLYNHRLRHEAEENPIICSICNVSFKSRKTFN 324
            |::..:..||.|:|...|.|||.:||..|||.:.|..|:..|..|: |..|:.|..:|..|.:..
Human   663 FTQNSHLARHRRVHTGGKPYQCNECGKAFSQTSKLARHQRVHTGEK-PYECNQCGKAFSVRSSLT 726

  Fly   325 HHTLIHKENRPRHYCSVCPKSFTERYTLKMHMKTHEGDVVYGVREEAPADEQ 376
            .|..||...:| :.|:.|.|.||:...|..|...|.|:..|...|...|..|
Human   727 THQAIHTGKKP-YKCNECGKVFTQNSHLARHRGIHTGEKPYKCNECGKAFSQ 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-delta	NP_524581.1	COG5048	<205..360	CDD:227381	51/182 (28%)
		C2H2 Zn finger	225..245	CDD:275368	7/19 (37%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		C2H2 Zn finger	281..301	CDD:275368	8/19 (42%)
		C2H2 Zn finger	310..327	CDD:275370	4/16 (25%)
		zf-C2H2	337..359	CDD:278523	7/21 (33%)
		C2H2 Zn finger	339..359	CDD:275368	7/19 (37%)
ZNF347	NP_001166145.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	265..284	CDD:275368
		COG5048	273..728	CDD:227381	50/195 (26%)
		zf-H2C2_2	276..301	CDD:290200
		C2H2 Zn finger	292..312	CDD:275368
		zf-H2C2_2	304..329	CDD:290200
		C2H2 Zn finger	320..340	CDD:275368
		zf-H2C2_2	333..357	CDD:290200
		C2H2 Zn finger	348..368	CDD:275368
		zf-H2C2_2	360..383	CDD:290200
		C2H2 Zn finger	376..396	CDD:275368
		zf-H2C2_2	388..413	CDD:290200
		C2H2 Zn finger	404..424	CDD:275368
		zf-H2C2_2	416..439	CDD:290200
		C2H2 Zn finger	432..452	CDD:275368
		zf-H2C2_2	444..469	CDD:290200
		zf-C2H2	458..480	CDD:278523
		C2H2 Zn finger	460..480	CDD:275368
		zf-H2C2_2	472..495	CDD:290200
		C2H2 Zn finger	488..508	CDD:275368
		zf-H2C2_2	500..525	CDD:290200
		C2H2 Zn finger	516..536	CDD:275368
		zf-H2C2_2	528..552	CDD:290200	2/11 (18%)
		C2H2 Zn finger	544..564	CDD:275368	3/21 (14%)
		zf-H2C2_2	556..581	CDD:290200	7/30 (23%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		zf-H2C2_2	584..609	CDD:290200	6/25 (24%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		C2H2 Zn finger	628..648	CDD:275368	0/19 (0%)
		zf-H2C2_2	640..665	CDD:290200	6/24 (25%)
		C2H2 Zn finger	656..676	CDD:275368	7/19 (37%)
		zf-H2C2_2	668..693	CDD:290200	11/24 (46%)
		C2H2 Zn finger	684..704	CDD:275368	8/19 (42%)
		zf-H2C2_2	697..720	CDD:290200	7/23 (30%)
		C2H2 Zn finger	712..732	CDD:275368	5/19 (26%)
		COG5048	723..>817	CDD:227381	17/56 (30%)
		zf-H2C2_2	724..749	CDD:290200	8/25 (32%)
		C2H2 Zn finger	740..760	CDD:275368	7/19 (37%)
		zf-H2C2_2	752..777	CDD:290200	7/24 (29%)
		C2H2 Zn finger	768..788	CDD:275368	3/10 (30%)
		C2H2 Zn finger	795..813	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142382
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930