DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-delta and ZNF99

DIOPT Version :9

Sequence 1:	NP_524581.1	Gene:	Sry-delta / 43572	FlyBaseID:	FBgn0003512	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001073878.2	Gene:	ZNF99 / 7652	HGNCID:	13175	Length:	864	Species:	Homo sapiens

Alignment Length:	235	Identity:	69/235 - (29%)
Similarity:	96/235 - (40%)	Gaps:	17/235 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 KKRVKQECTTCGKVYNSWYQLQKHISEEHSKQPNHICPICGVIRRDEEYLELHMNLHEGKTEKQC 253
            ||..|  |..|||.:|:...|.||......|:| :.|..||...:...:|..|..:|.|:...:|
Human   534 KKPYK--CEECGKAFNNSSTLMKHKIIHTGKKP-YKCEECGKAFKQSSHLTRHKAIHTGEKPYKC 595

  Fly   254 RYCPKSFSRPVNTLRHMRMHWDKKKYQCEKCGLRFSQDNLLYNHRLRHEAEENPIICSICNVSFK 318
            ..|.|:|:......:|..:|..||.|:||:||..|||.:.|..|.:.|..|: |..|..|..:||
Human   596 EECGKAFNHFSALRKHQIIHTGKKPYKCEECGKAFSQSSTLRKHEIIHTGEK-PYKCEECGKAFK 659

  Fly   319 SRKTFNHHTLIHKENRPRHYCSVCPKSFTERYTLKMHMKTHEGDVVYGVREEAPADEQQVVEELH 383
            .......|.:||.|.:| :.|..|.|:|.....|:.|...|.|...|...|...|..|......|
Human   660 WSSHLTRHKVIHTEEKP-YKCEECGKAFNHFSALRKHKIIHTGKKPYKCEECGKAFSQSSTLRKH 723

  Fly   384 VDVDESEAAVTVIMSDNDENSGFCLICNTNFENKKELEHH 423
            ..:...|....            |..|...|:...:|..|
Human   724 EIIHTGEKPYK------------CEECGKAFKWSSKLTVH 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-delta	NP_524581.1	COG5048	<205..360	CDD:227381	48/154 (31%)
		C2H2 Zn finger	225..245	CDD:275368	5/19 (26%)
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		C2H2 Zn finger	281..301	CDD:275368	9/19 (47%)
		C2H2 Zn finger	310..327	CDD:275370	4/16 (25%)
		zf-C2H2	337..359	CDD:278523	6/21 (29%)
		C2H2 Zn finger	339..359	CDD:275368	6/19 (32%)
ZNF99	NP_001073878.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		C2H2 Zn finger	232..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		COG5048	267..684	CDD:227381	52/154 (34%)
		zf-H2C2_2	272..296	CDD:290200
		C2H2 Zn finger	287..307	CDD:275368
		zf-H2C2_2	299..324	CDD:290200
		C2H2 Zn finger	315..335	CDD:275368
		zf-H2C2_2	327..352	CDD:290200
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		zf-H2C2_2	383..407	CDD:290200
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		zf-H2C2_2	467..491	CDD:290200
		C2H2 Zn finger	483..503	CDD:275368
		C2H2 Zn finger	511..531	CDD:275368
		zf-H2C2_2	523..548	CDD:290200	7/15 (47%)
		COG5048	534..857	CDD:227381	69/235 (29%)
		C2H2 Zn finger	539..559	CDD:275368	8/19 (42%)
		zf-H2C2_2	552..576	CDD:290200	8/24 (33%)
		C2H2 Zn finger	567..587	CDD:275368	5/19 (26%)
		zf-H2C2_2	579..604	CDD:290200	8/24 (33%)
		C2H2 Zn finger	595..615	CDD:275368	5/19 (26%)
		zf-H2C2_2	607..632	CDD:290200	10/24 (42%)
		C2H2 Zn finger	623..643	CDD:275368	9/19 (47%)
		zf-H2C2_2	636..659	CDD:290200	7/23 (30%)
		C2H2 Zn finger	651..671	CDD:275368	5/19 (26%)
		zf-H2C2_2	663..688	CDD:290200	9/25 (36%)
		C2H2 Zn finger	679..699	CDD:275368	6/19 (32%)
		zf-H2C2_2	691..716	CDD:290200	7/24 (29%)
		C2H2 Zn finger	707..727	CDD:275368	4/19 (21%)
		zf-H2C2_2	720..743	CDD:290200	4/34 (12%)
		C2H2 Zn finger	735..755	CDD:275368	5/17 (29%)
		C2H2 Zn finger	763..783	CDD:275368
		zf-H2C2_2	775..800	CDD:290200
		C2H2 Zn finger	791..811	CDD:275368
		C2H2 Zn finger	819..839	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142245
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930