DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-delta and ZNF107

DIOPT Version :9

Sequence 1:	NP_524581.1	Gene:	Sry-delta / 43572	FlyBaseID:	FBgn0003512	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001374954.1	Gene:	ZNF107 / 51427	HGNCID:	12887	Length:	896	Species:	Homo sapiens

Alignment Length:	229	Identity:	64/229 - (27%)
Similarity:	100/229 - (43%)	Gaps:	12/229 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 CEDVDVGDSEAL---YGKSSDGEDRPTKKRVKQECTTCGKVYNSWYQLQKHISEEHSKQPNHICP 226
            ||:.|...:.:|   ..|....|::|.|      |..||||:|.:..|.:| ...|:.:..:.|.
Human   415 CEECDKAFNRSLKLTAHKKILMEEKPYK------CEECGKVFNQFSTLTRH-KIIHTGEKPYKCK 472

  Fly   227 ICGVIRRDEEYLELHMNLHEGKTEKQCRYCPKSFSRPVNTLRHMRMHWDKKKYQCEKCGLRFSQD 291
            .||........|..|..:|..:...:|..|.|:|::..|.:.|.:::..:|.|:||:||..|::.
Human   473 ECGKAFNQSSNLTEHKKIHTAEKSYKCEECGKAFNQHSNLINHRKIYSGEKPYKCEECGKAFNRS 537

  Fly   292 NLLYNHRLRHEAEENPIICSICNVSFKSRKTFNHHTLIHKENRPRHYCSVCPKSFTERYTLKMHM 356
            :.|..|:..|..|: |..|..|:.:|........|..||...:| :.|..|.|:|....||..|.
Human   538 STLTRHKKIHTGEK-PYKCEECDRAFSQSSNLTEHKKIHTGEKP-YKCEECGKAFNRFSTLTKHK 600

  Fly   357 KTHEGDVVYGVREEAPADEQQVVEELHVDVDESE 390
            :.|.|:..|...|...|..|......|..|...|
Human   601 RIHTGEKPYKCEECGKAFNQSYQLTRHKIVHTKE 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-delta	NP_524581.1	COG5048	<205..360	CDD:227381	41/154 (27%)
		C2H2 Zn finger	225..245	CDD:275368	5/19 (26%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		C2H2 Zn finger	310..327	CDD:275370	3/16 (19%)
		zf-C2H2	337..359	CDD:278523	7/21 (33%)
		C2H2 Zn finger	339..359	CDD:275368	7/19 (37%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630
		C2H2 Zn finger	191..211	CDD:275368
		C2H2 Zn finger	219..239	CDD:275368
		COG5048	243..621	CDD:227381	60/214 (28%)
		C2H2 Zn finger	247..267	CDD:275368
		C2H2 Zn finger	275..295	CDD:275368
		C2H2 Zn finger	303..323	CDD:275368
		C2H2 Zn finger	331..351	CDD:275368
		C2H2 Zn finger	359..379	CDD:275368
		C2H2 Zn finger	387..407	CDD:275368
		C2H2 Zn finger	415..435	CDD:275368	5/19 (26%)
		C2H2 Zn finger	443..463	CDD:275368	8/20 (40%)
		C2H2 Zn finger	471..491	CDD:275368	5/19 (26%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		COG5048	551..>863	CDD:227381	24/86 (28%)
		C2H2 Zn finger	555..575	CDD:275368	4/19 (21%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		C2H2 Zn finger	611..631	CDD:275368	4/19 (21%)
		C2H2 Zn finger	639..659	CDD:275368
		C2H2 Zn finger	699..715	CDD:275368
		C2H2 Zn finger	723..743	CDD:275368
		C2H2 Zn finger	751..771	CDD:275368
		C2H2 Zn finger	779..799	CDD:275368
		C2H2 Zn finger	807..827	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	863..883	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142196
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930