DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sry-delta and CG8478

DIOPT Version :9

Sequence 1:	NP_524581.1	Gene:	Sry-delta / 43572	FlyBaseID:	FBgn0003512	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001163576.1	Gene:	CG8478 / 41194	FlyBaseID:	FBgn0037746	Length:	576	Species:	Drosophila melanogaster

Alignment Length:	463	Identity:	83/463 - (17%)
Similarity:	143/463 - (30%)	Gaps:	171/463 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AVDLSDTGSSSSMRYE-------TLSAKVPSSQKTVSLVLTHLANCIQT------QLDLKPGARL 60
            ::||:......:.:.|       |||:.|..:..||.      ||.::|      .:.|:..|:.
  Fly   133 SIDLTQIDDKENTQPEGCGGDNSTLSSSVDVTANTVK------ANTLKTGDATMDNVSLQEAAKT 191

  Fly    61 -CPRCFQELSDYDTIMVNLMTTQKRLTTQLKGALKSEFEVPESGEDILVEEV-EIPQSDVETDAD 123
             .|.....|| .:.::.|:........:.|.....:|.||....|  :|.|| |:....::..||
  Fly   192 PAPSQVYPLS-ANVVLENITEVSNEGVSMLVSPAGAEKEVAHVNE--VVNEVSELIAKALKISAD 253

  Fly   124 AEADA---LFVELVKDQEESDTEIKREFVDEEEEEDDDDDDEFICEDVDVGDSEALYGKSSDGED 185
            :...|   |.||..|.::...:......:......                     |..::..|.
  Fly   254 SVKPATSKLKVEAGKKRQSMSSTYSGAALPRPRRS---------------------YLPTTTAET 297

  Fly   186 R------------------PTKKR--------VKQECTTCGKVYNSWYQLQKHISEEHSKQPNHI 224
            |                  |.:||        .::.|....|:..|  .::|.::....:.|..|
  Fly   298 RTYSFKQRMSVVVKTTLNSPARKRSVGGGVSLSRRSCLPVSKLTKS--SIRKSLAVTSVRSPEKI 360

  Fly   225 ------------------CPICGVIRRDEEYLELHMNLHE-------------------GKTEKQ 252
                              |..|....|.:..|::||.:|:                   |.::.:
  Fly   361 ASKPAKTSTKSIPEKVFSCKNCSTTFRVKSLLDVHMRMHDPVDNGANTLKRLNSNPVAAGVSKNR 425

  Fly   253 CRYCPKSFSRPVNTLRHMRMHWDK-----------------KKYQCEKCG--------------- 285
            |::|.|:|:.......|:..:.||                 ||.|..|.|
  Fly   426 CKFCDKNFALERALHIHLMQNCDKIPPSEKRKLEFTELNHEKKAQLPKIGGTSGINHPMTMPQKP 490

  Fly   286 ---------LRFSQ--------------DNLLYNHRLRHEAEENPIICSICNVSFKSRKTFNHHT 327
                     |..||              .|:.:....|...:..|  |.||..||:|...|.:|:
  Fly   491 QQRISTIPKLAPSQGTQSMAPPSVKKIPKNVAHAGVYRTPTKTVP--CHICKQSFRSILEFTNHS 553

  Fly   328 L-IHKENR 334
            | :|..|:
  Fly   554 LTVHGNNQ 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-delta	NP_524581.1	COG5048	<205..360	CDD:227381	41/223 (18%)
		C2H2 Zn finger	225..245	CDD:275368	6/19 (32%)
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		C2H2 Zn finger	281..301	CDD:275368	6/57 (11%)
		C2H2 Zn finger	310..327	CDD:275370	7/16 (44%)
		zf-C2H2	337..359	CDD:278523
		C2H2 Zn finger	339..359	CDD:275368
CG8478	NP_001163576.1	zf-C2H2	377..399	CDD:278523	6/21 (29%)
		C2H2 Zn finger	379..399	CDD:275368	6/19 (32%)
		C2H2 Zn finger	426..444	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100