DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-delta and CG2678

DIOPT Version :9

Sequence 1:	NP_524581.1	Gene:	Sry-delta / 43572	FlyBaseID:	FBgn0003512	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster

Alignment Length:	440	Identity:	86/440 - (19%)
Similarity:	148/440 - (33%)	Gaps:	139/440 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LTH-LANCIQTQL---DLKPGARLCPRCFQELSDYDTIMVNLMTTQKRLTTQLKGALKSEFEVPE 101
            |:| ||.|.:..:   ||.| ..:|..|                     ...::.|.:.:::..:
  Fly    38 LSHILARCTERPVKRGDLLP-QFICVSC---------------------VLAVQNAFRFKWQSEQ 80

  Fly   102 SGEDI--LVEEVEIPQSDVETDADAEADALFVELVKDQEESDTEIKREFVDEEEEEDDDDDDEFI 164
            |.:..  ::.:...|::.|.. |....|...:...|.|.:||.:...:.:.:.::.||
  Fly    81 SYQHFFRVLNQSGAPENQVHL-AACNGDKNQIINQKMQLKSDRQQDTQQMTKTQKPDD------- 137

  Fly   165 CEDVDVGDSEALYGKSSDGED---------RPTKKRVKQE------------------------- 195
                |:...:.|..|..:|..         .|.|:..:.|
  Fly   138 ----DLSQKQTLQAKLQEGNIDGPPESFTLHPRKRTCRTEEQADMIPKEATRSTKMICDADGYYN 198

  Fly   196 CTTCGKVYNSWYQLQKHISEEHSKQPNHICPICGVIRRDEEYLELHMNLHEGKTEKQCRYCPKSF 260
            |..|.|.:.|..||:.||::..::     ||.|......:..|:.|:..|..|...:|.:|.|:|
  Fly   199 CPHCSKRFCSQTQLRTHITDLCNR-----CPYCPRTYMQKSNLKRHLRNHLSKPAHKCFHCSKAF 258

  Fly   261 SRPVNTLRHMRMHWDKKKYQCEKCGLRFSQDNLLYNHRLRHEAEENPIICSICNVSFK------- 318
            .|..:..||:|.|.......|.:|...|.:...|..||..|:....    |..:.|.|
  Fly   259 MRKDHLKRHLRTHDSDGPLSCSQCSAVFIEHVQLEIHRREHKQRPG----SSKSESTKDPDSDDS 319

  Fly   319 ----------SRKTFNHHTLIHKENRPRHYCSVCPKSFTERYTLKMHMKTHEGDVVYGVREEAPA 373
                      ::.|||....|....:|:..|.:|.|.|:..|.||.||.||
  Fly   320 DQAQDLKPKWTKNTFNGTCSIPPMLKPKPICDICQKKFSSVYALKRHMLTH-------------- 370

  Fly   374 DEQQVVEELHVDVDESEAAVTVIMSDNDENSGFCLICNTNFENKKELEHH 423
            :.|..:::                         |..|:..|:.:|.|:.|
  Fly   371 NRQHHLKK-------------------------CTYCSEEFKTEKHLKRH 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-delta	NP_524581.1	COG5048	<205..360	CDD:227381	46/171 (27%)
		C2H2 Zn finger	225..245	CDD:275368	5/19 (26%)
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		C2H2 Zn finger	310..327	CDD:275370	6/33 (18%)
		zf-C2H2	337..359	CDD:278523	9/21 (43%)
		C2H2 Zn finger	339..359	CDD:275368	9/19 (47%)
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871	12/68 (18%)
		COG5048	220..>284	CDD:227381	18/68 (26%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		zf-C2H2	249..271	CDD:278523	8/21 (38%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	9/19 (47%)
		C2H2 Zn finger	379..399	CDD:275368	6/17 (35%)
		C2H2 Zn finger	406..427	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100