DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-delta and Neu2

DIOPT Version :9

Sequence 1:	NP_524581.1	Gene:	Sry-delta / 43572	FlyBaseID:	FBgn0003512	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster

Alignment Length:	395	Identity:	87/395 - (22%)
Similarity:	147/395 - (37%)	Gaps:	89/395 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 LCPRCFQELSD-YDTIMVNLMTTQKRLTTQLKGALKSEFEVPESGEDILVEEVEIPQSDVETDAD 123
            :|..|.::..: :|  ::.......:....||...:.|.|...||   ..||||..:.|::..||
  Fly    37 ICKSCLEDAQNAFD--IIETYERSHQFYRFLKDVREEESENDGSG---CSEEVEAAERDLQDGAD 96

  Fly   124 AEADALFVELVKDQEESDTEIKREFVDEEEEEDDDDDDEFIC----EDVDVGDSEALYGKSSDGE 184
            .      |:...:.:.::.:||.:           :...|.|    :...|..:..::.:|..||
  Fly    97 D------VDSGNEPDINECDIKAK-----------EKPGFSCSHCPKSFQVKSNLKVHMRSHTGE 144

  Fly   185 DRPTKKRVKQECTTCGKVYNSWYQLQKHISEEHSKQPNHICPICGVIRRDEEYLELHMNLHEGKT 249
             ||.      .|:.|.|.:.....||.|:.....::|.. |..|........:|:.|:.:||.:.
  Fly   145 -RPF------TCSLCPKSFGYSSGLQNHMRTHTGERPFQ-CSHCPRSFTAGHHLKAHIQMHERRG 201

  Fly   250 EKQCRYCPKSFSRPVNTLRHMRMHWDKKKYQCEKCGLRFSQDNLLYNHRLRHEAEENPIICSICN 314
            ..:|.||.|.|...:...:|:..|.|:.:::|.:|...|..::.|:.|...|  :|....|..|:
  Fly   202 SLRCPYCQKCFLTSLILKQHLATHTDETQFKCSQCSKSFQVEHELWMHMRVH--QERLFTCGHCS 264

  Fly   315 VSF-----------------KSRKTFNHHTLIHKENRPRHYCSVCPKSFTERYTLKMHMKTH--- 359
            ..|                 :|.|...|.||.|.:...   |..|||:||:|..|..|:|:|
  Fly   265 KDFALHAYLKRHLSRNARCSQSSKASAHKTLGHSKALK---CGKCPKTFTDRSALSTHLKSHTKN 326

  Fly   360 ----EGDVVYGVREEAPADEQQVVEELHVDVDESEAAVTVIMSDNDENSGFCLICNTNFENKKEL 420
                ||.......:.|.::.|:...:                         |..|...|..|..|
  Fly   327 KPLLEGPCKSSGSKPAHSNAQRKPFK-------------------------CSSCPRTFSRKSAL 366

  Fly   421 EHHLQ 425
            ..|||
  Fly   367 LTHLQ 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-delta	NP_524581.1	COG5048	<205..360	CDD:227381	45/178 (25%)
		C2H2 Zn finger	225..245	CDD:275368	4/19 (21%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		C2H2 Zn finger	281..301	CDD:275368	5/19 (26%)
		C2H2 Zn finger	310..327	CDD:275370	6/33 (18%)
		zf-C2H2	337..359	CDD:278523	10/21 (48%)
		C2H2 Zn finger	339..359	CDD:275368	10/19 (53%)
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071	3/27 (11%)
		COG5048	<119..241	CDD:227381	31/129 (24%)
		C2H2 Zn finger	121..141	CDD:275368	2/19 (11%)
		zf-H2C2_2	133..158	CDD:290200	8/31 (26%)
		C2H2 Zn finger	149..169	CDD:275368	6/19 (32%)
		zf-H2C2_2	162..185	CDD:290200	6/23 (26%)
		C2H2 Zn finger	177..197	CDD:275368	4/19 (21%)
		C2H2 Zn finger	205..225	CDD:275368	6/19 (32%)
		zf-C2H2_8	206..286	CDD:292531	17/81 (21%)
		C2H2 Zn finger	233..253	CDD:275368	5/19 (26%)
		C2H2 Zn finger	260..297	CDD:275368	8/36 (22%)
		C2H2 Zn finger	303..323	CDD:275368	10/19 (53%)
		C2H2 Zn finger	353..373	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100