DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-delta and ZNF785

DIOPT Version :9

Sequence 1:	NP_524581.1	Gene:	Sry-delta / 43572	FlyBaseID:	FBgn0003512	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	XP_011544054.1	Gene:	ZNF785 / 146540	HGNCID:	26496	Length:	418	Species:	Homo sapiens

Alignment Length:	376	Identity:	91/376 - (24%)
Similarity:	131/376 - (34%)	Gaps:	110/376 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 GALKSEFEVPESGEDILVEEVEIPQS---DVETDADAEADALFVELVKDQEESDTEIKREFVDEE 152
            |.|.:..|...||.|        |||   .|...|       |:..|:.:.|:.:         .
Human    63 GHLGALGEAGPSGRD--------PQSVGFSVPKPA-------FISWVEGEVEAWS---------P 103

  Fly   153 EEEDDDDDDEFICEDVDVGDSEALYGK-------SSDGEDR-------PTKKRVKQE-------- 195
            |.:|.|            |:|.|.:.:       |.||.:.       |.:|.|..|
Human   104 EAQDPD------------GESSAAFSRGQGQEAGSRDGNEEKERLKKCPKQKEVAHEVAVKEWWP 156

  Fly   196 -------CTTCGKVYNSWYQLQKHISEEHSKQPNHICPICGVIRRDEEY---LELHMNLHEGKTE 250
                   |.......|.|      :.:..:::..|.||.||   |:..|   |..|..:|.|:..
Human   157 SVACPEFCNPRQSPMNPW------LKDTLTRRLPHSCPDCG---RNFSYPSLLASHQRVHSGERP 212

  Fly   251 KQCRYCPKSFSRPVNTLRHMRMHWDKKKYQCEKCGLRFSQDNLLYNHRLRHEAEENPIICSICNV 315
            ..|..|...||:....|:|..:|..:|.|.|..||.||.|...|..||..|..|: |..||.|
Human   213 FSCGQCQARFSQRRYLLQHQFIHTGEKPYPCPDCGRRFRQRGSLAIHRRAHTGEK-PYACSDC-- 274

  Fly   316 SFKSRKTFNHHTLIHKE----NRPRHYCSVCPKSFTERYTLKMHMKTHEGDVVYGVREEAPADEQ 376
              |||.|:.:...||:.    .:| :.|..|...|.....|.:|.:.|.|:..|      |..
Human   275 --KSRFTYPYLLAIHQRKHTGEKP-YSCPDCSLRFAYTSLLAIHRRIHTGEKPY------PCP-- 328

  Fly   377 QVVEELHVDVDESEAAVTVIMS----DNDENSGFCLICNTNFENKKELEHH 423
                    |........::::|    .:|.....|:.|...|:.|..||.|
Human   329 --------DCGRRFTYSSLLLSHRRIHSDSRPFPCVECGKGFKRKTALEAH 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-delta	NP_524581.1	COG5048	<205..360	CDD:227381	48/161 (30%)
		C2H2 Zn finger	225..245	CDD:275368	8/22 (36%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		C2H2 Zn finger	281..301	CDD:275368	9/19 (47%)
		C2H2 Zn finger	310..327	CDD:275370	7/16 (44%)
		zf-C2H2	337..359	CDD:278523	5/21 (24%)
		C2H2 Zn finger	339..359	CDD:275368	5/19 (26%)
ZNF785	XP_011544054.1	KRAB	29..102	CDD:214630	14/53 (26%)
		COG5048	<156..372	CDD:227381	64/247 (26%)
		C2H2 Zn finger	187..207	CDD:275368	8/22 (36%)
		C2H2 Zn finger	215..235	CDD:275368	6/19 (32%)
		C2H2 Zn finger	243..263	CDD:275368	9/19 (47%)
		C2H2 Zn finger	271..291	CDD:275368	9/23 (39%)
		C2H2 Zn finger	299..319	CDD:275368	5/19 (26%)
		C2H2 Zn finger	327..347	CDD:275368	2/29 (7%)
		C2H2 Zn finger	355..375	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910