DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and ZNF561

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	XP_024307548.1	Gene:	ZNF561 / 93134	HGNCID:	28684	Length:	502	Species:	Homo sapiens

Alignment Length:	359	Identity:	93/359 - (25%)
Similarity:	141/359 - (39%)	Gaps:	62/359 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CGKEKSVGVFQLIEGCIV---------PGTFKPIKDILKYFEKIINQRLELLPNSAACRDCLEYL 66
            |||     ||.|..|..|         |...|......|||..:.| .:.:..:...|.     .
Human   190 CGK-----VFTLTPGLAVHLEVLNARQPYKCKECGKGFKYFASLDN-HMGIHTDEKLCE-----F 243

  Fly    67 FNYDRLVRNLSQVQRQIADALLGCRQVE-GKAETKQQAAKRARVQVPAFKIVQATALKEPERQPG 130
            ..|.|.|...|.:::        |..|. ||   |.:..|:.......|..:.|..    :...|
Human   244 QEYGRAVTASSHLKQ--------CVAVHTGK---KSKKTKKCGKSFTNFSQLYAPV----KTHKG 293

  Fly   131 EED-ECEE----FMKEEMLDEEFQFSEPDDSMPSSEEEFFTETTEIPCHICGEMFSSQEVLERHI 190
            |:. ||:|    |.....|::..|              ..|......|..||:.|:....|..|:
Human   294 EKSFECKECGRSFRNSSCLNDHIQ--------------IHTGIKPHKCTYCGKAFTRSTQLTEHV 344

  Fly   191 KADTCQKSEQATCNVCGLKVKDDEVLDLHMNLHEGKTELECRYCDKKFSHKRNVLRHMEVHWDKK 255
            :..|..|..:  |..||........|.:|:..|.||...:|:.|.|.|:...::::|..:|..:|
Human   345 RTHTGIKPYE--CKECGQAFAQYSGLSIHIRSHSGKKPYQCKECGKAFTTSTSLIQHTRIHTGEK 407

  Fly   256 KYQCDKCGERFSLSWLMYNHLMRHDAEENALICEVCHQQFKTKRTYKHHLRTHQTDRPRYPCPDC 320
            .|:|.:||:.|..|.....||..|..|: ..:|::|.:.|........|||||..::| :.|.:|
Human   408 PYECVECGKTFITSSRRSKHLKTHSGEK-PFVCKICGKAFLYSSRLNVHLRTHTGEKP-FVCKEC 470

  Fly   321 EKSFVDKYTLKVHKRVHQPVEKPESAEAKEATVT 354
            .|:|.....|..|:|:|.. |||  .|.|:.:||
Human   471 GKAFAVSSRLSRHERIHTG-EKP--YECKDMSVT 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		C2H2 Zn finger	231..251	CDD:275368	5/19 (26%)
		C2H2 Zn finger	259..308	CDD:275368	15/48 (31%)
		C2H2 Zn finger	288..303	CDD:275370	3/14 (21%)
		zf-C2H2	315..337	CDD:278523	7/21 (33%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
ZNF561	XP_024307548.1	KRAB	56..96	CDD:307490
		C2H2 Zn finger	190..207	CDD:275370	8/21 (38%)
		C2H2 Zn finger	215..235	CDD:275368	5/20 (25%)
		C2H2 Zn finger	243..263	CDD:275368	5/27 (19%)
		COG5048	<287..483	CDD:227381	56/217 (26%)
		C2H2 Zn finger	299..319	CDD:275368	5/33 (15%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		C2H2 Zn finger	355..375	CDD:275368	5/19 (26%)
		C2H2 Zn finger	383..403	CDD:275368	5/19 (26%)
		C2H2 Zn finger	411..431	CDD:275368	7/19 (37%)
		C2H2 Zn finger	439..459	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000