DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and ZNF300

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_001166302.1	Gene:	ZNF300 / 91975	HGNCID:	13091	Length:	620	Species:	Homo sapiens

Alignment Length:	329	Identity:	78/329 - (23%)
Similarity:	133/329 - (40%)	Gaps:	62/329 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YLFNYDRLVRNLSQVQRQIADALLG------------CRQVEGKAET--KQQAAK---RARVQVP 112
            :|.|.|:|.|.::.|..:......|            |.:.:...:.  |..|.|   :..:.:|
Human   153 FLENQDKLFRQVTFVNSKTVTEASGHKYNPLGKIFQECIETDISIQRFHKYDAFKKNLKPNIDLP 217

  Fly   113 AFKIVQATALKEPERQ------------------------PGEEDECEEFMKEEMLDEEFQFSEP 153
            :  ..::.:.|:|::.                        |.::::|....:......::|..|
Human   218 S--CYKSNSRKKPDQSFGGGKSSSQSEPNSNLEKIHNGVIPFDDNQCGNVFRNTQSLIQYQNVE- 279

  Fly   154 DDSMPSSEEEFFTETTEIPCHICGEMFSSQEVLERHIKADTCQKSEQATCNVCGLKVKDDEVLDL 218
                        |:.....|..||:.|:.:..|..|.:..|.:|...  |..||....:...|.:
Human   280 ------------TKEKSCVCVTCGKAFAKKSQLIVHQRIHTGKKPYD--CGACGKAFSEKFHLVV 330

  Fly   219 HMNLHEGKTELECRYCDKKFSHKRNVLRHMEVHWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEE 283
            |...|.|:...:|..|.|.||.|.:::.|..||..:|.|:|.:||:.||....:..|...|..|:
Human   331 HQRTHTGEKPYDCSECGKAFSQKSSLIIHQRVHTGEKPYECSECGKAFSQKSPLIIHQRIHTGEK 395

  Fly   284 NALICEVCHQQFKTKRTYKHHLRTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVHQPVEKP-ESAE 347
             ...|..|.:.|..|.....|.|.|..::| |.|.:|.|:|.:|..|.:|||:|.. ||| :.|:
Human   396 -PYECRECGKAFSQKSQLIIHHRAHTGEKP-YECTECGKAFCEKSHLIIHKRIHTG-EKPYKCAQ 457

  Fly   348 AKEA 351
            .:||
Human   458 CEEA 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		C2H2 Zn finger	231..251	CDD:275368	7/19 (37%)
		C2H2 Zn finger	259..308	CDD:275368	14/48 (29%)
		C2H2 Zn finger	288..303	CDD:275370	4/14 (29%)
		zf-C2H2	315..337	CDD:278523	10/21 (48%)
		C2H2 Zn finger	317..337	CDD:275368	9/19 (47%)
ZNF300	NP_001166302.1	KRAB	24..84	CDD:214630
		KRAB	24..63	CDD:279668
		COG5048	258..616	CDD:227381	63/222 (28%)
		C2H2 Zn finger	260..279	CDD:275368	2/18 (11%)
		C2H2 Zn finger	287..307	CDD:275368	6/19 (32%)
		C2H2 Zn finger	315..335	CDD:275368	5/19 (26%)
		zf-H2C2_2	327..352	CDD:290200	8/24 (33%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		zf-H2C2_2	355..380	CDD:290200	9/24 (38%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		zf-H2C2_2	384..408	CDD:290200	6/24 (25%)
		C2H2 Zn finger	399..419	CDD:275368	6/19 (32%)
		zf-H2C2_2	412..434	CDD:290200	8/22 (36%)
		C2H2 Zn finger	427..447	CDD:275368	9/19 (47%)
		zf-H2C2_2	439..464	CDD:290200	11/24 (46%)
		C2H2 Zn finger	455..475	CDD:275368	3/7 (43%)
		zf-H2C2_2	467..492	CDD:290200
		zf-C2H2	481..503	CDD:278523
		C2H2 Zn finger	483..503	CDD:275368
		zf-H2C2_2	496..518	CDD:290200
		C2H2 Zn finger	511..531	CDD:275368
		zf-H2C2_2	527..548	CDD:290200
		C2H2 Zn finger	539..559	CDD:275368
		zf-H2C2_2	555..576	CDD:290200
		C2H2 Zn finger	567..587	CDD:275368
		zf-H2C2_2	579..604	CDD:290200
		C2H2 Zn finger	595..615	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000