DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and ZNF142

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_001353219.1	Gene:	ZNF142 / 7701	HGNCID:	12927	Length:	1887	Species:	Homo sapiens

Alignment Length:	193	Identity:	58/193 - (30%)
Similarity:	89/193 - (46%)	Gaps:	16/193 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 TTEIP--CHICGEMFSSQEVLERHIKADTCQKSEQATCNVCGLKVKDDEVLDLHMNLHEGKTEL- 229
            |.|.|  ||:|....:....|:.|::..  ::..:..|..||.|.|....|..||..|.|....
Human  1675 TGEKPYHCHLCPYACADPSRLKYHMRIH--KEERKYLCPECGYKCKWVNQLKYHMTKHTGLKPYQ 1737

  Fly   230 --ECRYCDKKFSHKRNVLR-HMEV-HWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENALICEV 290
              ||.||    :::.:.|| |.|. |.:.:.:.|::||:.|...:|:..||.:| :|....:|.|
Human  1738 CPECEYC----TNRADALRVHQETRHREARAFMCEQCGKAFKTRFLLRTHLRKH-SEAKPYVCNV 1797

  Fly   291 CHQQFKTKRTYKHHLRTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVHQPVE-KPESAEAKEAT 352
            ||:.|:.....:||..|| |||..:.|..|......|:.:..|.|.|.|.: .|.....|:.|
Human  1798 CHRAFRWAAGLRHHALTH-TDRHPFFCRLCNYKAKQKFQVVKHVRRHHPDQADPNQGVGKDPT 1859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	8/19 (42%)
		C2H2 Zn finger	231..251	CDD:275368	7/21 (33%)
		C2H2 Zn finger	259..308	CDD:275368	16/48 (33%)
		C2H2 Zn finger	288..303	CDD:275370	5/14 (36%)
		zf-C2H2	315..337	CDD:278523	5/21 (24%)
		C2H2 Zn finger	317..337	CDD:275368	5/19 (26%)
ZNF142	NP_001353219.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		C2H2 Zn finger	365..385	CDD:275368
		C2H2 Zn finger	393..413	CDD:275368
		C2H2 Zn finger	421..438	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	545..566	CDD:275368
		C2H2 Zn finger	574..595	CDD:275368
		zf-H2C2_5	601..625	CDD:404746
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..651	CDD:275368
		C2H2 Zn finger	659..679	CDD:275368
		C2H2 Zn finger	687..707	CDD:275368
		C2H2 Zn finger	714..731	CDD:275368
		PHA03247	928..>1219	CDD:223021
		C2H2 Zn finger	1306..1353	CDD:275368
		C2H2 Zn finger	1373..1394	CDD:275368
		C2H2 Zn finger	1402..1422	CDD:275368
		C2H2 Zn finger	1430..1451	CDD:275368
		C2H2 Zn finger	1626..1646	CDD:275368
		C2H2 Zn finger	1654..1674	CDD:275368
		C2H2 Zn finger	1682..1702	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1710..1730	CDD:275368	8/19 (42%)
		zf-H2C2_2	1723..1747	CDD:404364	9/27 (33%)
		C2H2 Zn finger	1738..1759	CDD:275368	8/24 (33%)
		C2H2 Zn finger	1767..1787	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1795..1815	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1823..1843	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100