DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sry-beta and ZNF2

DIOPT Version :9

Sequence 1:NP_001303451.1 Gene:Sry-beta / 43570 FlyBaseID:FBgn0003511 Length:356 Species:Drosophila melanogaster
Sequence 2:NP_001278534.1 Gene:ZNF2 / 7549 HGNCID:12991 Length:438 Species:Homo sapiens


Alignment Length:311 Identity:78/311 - (25%)
Similarity:133/311 - (42%) Gaps:37/311 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 RDCLEYLFNYDRLVRNLSQVQRQIADALLGCRQVEGKAETKQQAAKRARVQVPAFKIVQATALKE 124
            ::|:.:||..|      .:.:.:|.||  ..::.||   :.::...|.....|.|::........
Human    95 KNCICFLFVPD------WETKPEIHDA--SDKKSEG---SLRECLGRQSPLCPKFEVHTPNGRMG 148

  Fly   125 PERQ-PGEEDECEEFMKEE------MLDEEFQFSEPDDSMPSSEEEFF----------TETTEIP 172
            .|:| |..|...:...:::      .|..|....|.........:.||          |.|.|.|
Human   149 TEKQSPSGETRKKSLSRDKGLRRRSALSREILTKERHQECSDCGKTFFDHSSLTRHQRTHTGEKP 213

  Fly   173 --CHICGEMFSSQEVLERHIKADTCQKSEQATCNVCGLKVKDDEVLDLHMNLHEGKTELECRYCD 235
              |..||:.||.:..|.||:.:.|.:...:  |:||.....|...|.:|..:|.|:...:|..|.
Human   214 YDCRECGKAFSHRSSLSRHLMSHTGESPYE--CSVCSKAFFDRSSLTVHQRIHTGEKPFQCNECG 276

  Fly   236 KKFSHKRNVLRHMEVHWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENALICEVCHQQFKTKRT 300
            |.|..:.::.||..:|..:..|:|.:||:.||...::..|.:.|...: ...|..|.:.|....:
Human   277 KAFFDRSSLTRHQRIHTGESPYECHQCGKAFSQKSILTRHQLIHTGRK-PYECNECGKAFYGVSS 340

  Fly   301 YKHHLRTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVH---QPVEKPESAEA 348
            ...|.:.|..| |||.|.:|.|:|.|:.:|..|:::|   :|.|..|..:|
Human   341 LNRHQKAHAGD-PRYQCNECGKAFFDRSSLTQHQKIHTGDKPYECSECGKA 390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sry-betaNP_001303451.1 C2H2 Zn finger 203..223 CDD:275368 6/19 (32%)
C2H2 Zn finger 231..251 CDD:275368 6/19 (32%)
C2H2 Zn finger 259..308 CDD:275368 11/48 (23%)
C2H2 Zn finger 288..303 CDD:275370 3/14 (21%)
zf-C2H2 315..337 CDD:278523 8/21 (38%)
C2H2 Zn finger 317..337 CDD:275368 7/19 (37%)
ZNF2NP_001278534.1 KRAB 14..74 CDD:214630
KRAB 14..53 CDD:279668
zf-C2H2 187..208 CDD:278523 2/20 (10%)
C2H2 Zn finger 188..208 CDD:275368 2/19 (11%)
COG5048 <199..425 CDD:227381 57/196 (29%)
zf-H2C2_2 200..225 CDD:290200 8/24 (33%)
C2H2 Zn finger 216..236 CDD:275368 8/19 (42%)
zf-H2C2_2 228..251 CDD:290200 7/24 (29%)
C2H2 Zn finger 244..264 CDD:275368 6/19 (32%)
zf-H2C2_2 256..279 CDD:290200 7/22 (32%)
C2H2 Zn finger 272..292 CDD:275368 6/19 (32%)
zf-H2C2_2 284..309 CDD:290200 8/24 (33%)
C2H2 Zn finger 300..320 CDD:275368 6/19 (32%)
zf-H2C2_2 313..335 CDD:290200 4/22 (18%)
C2H2 Zn finger 328..348 CDD:275368 4/19 (21%)
zf-C2H2 354..376 CDD:278523 8/21 (38%)
C2H2 Zn finger 356..376 CDD:275368 7/19 (37%)
zf-H2C2_2 368..393 CDD:290200 7/23 (30%)
C2H2 Zn finger 384..404 CDD:275368 2/7 (29%)
zf-H2C2_2 397..421 CDD:290200
C2H2 Zn finger 412..430 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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