Protein Alignment Sry-beta and ZFP37

DIOPT Version :9

• Sequence 1: NP_001303451.1
• Gene: Sry-beta / 43570
• FlyBaseID: FBgn0003511
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: NP_001269444.1
• Gene: ZFP37 / 7539
• HGNCID: 12863
• Length: 645
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 84/326 - (25%)
• Similarity: 138/326 - (42%)
• Gaps: 36/326 - (11%)

  Fly    34 PIKDILKYFE---KIINQRLELLPNSAACRDCLEYLFNYDRLVRNLSQVQRQIADALLGCRQVEG 95
            |.|..|..||   ||:.|.|:|..:|   |:|::.  ..|....:.......::|...|.:|...
Human   184 PSKKRLLKFESCGKILKQNLDLPDHS---RNCVKR--KSDAAKEHKKSFNHSLSDTRKGKKQTGK 243

  Fly    96 KAETKQQAAKRARVQVPAFK-----IVQATALKEPERQPGEEDECEEFMKEEMLDEEFQFSEPDD 155
            |.|.....:...:......|     ...::.:|:.:.|.||:.|     |...|....:..:|..
Human   244 KHEKLSSHSSSDKCNKTGKKHDKLCCHSSSHIKQDKIQTGEKHE-----KSPSLSSSTKHEKPQA 303

  Fly   156 SMPSSEEEFFTETTEIPCHICGEMFSSQEVLERHIKADTCQKSEQATCNVCGLKVKDDEVLDLHM 220
            .:...|           |:.||::.|.::.|..|.:..|.:|..:  ||.||:.......|.:|.
Human   304 CVKPYE-----------CNQCGKVLSHKQGLIDHQRVHTGEKPYE--CNECGIAFSQKSHLVVHQ 355

  Fly   221 NLHEGKTELECRYCDKKFSHKRNVLRHMEVHWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENA 285
            ..|.|:...||..|.|...||..:..|:.:|..:|.|:|.:||:.|..|..:..|:..|..|: .
Human   356 RTHTGEKPYECIQCGKAHGHKHALTDHLRIHTGEKPYECAECGKTFRHSSNLIQHVRSHTGEK-P 419

  Fly   286 LICEVCHQQFKTKRTYKHHLRTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVH---QPVEKPESAE 347
            ..|:.|.:.|:...:...|:|||..:.| |.|.:|.|:|....:|..|.|:|   :|.|..|..:
Human   420 YECKECGKSFRYNSSLTEHVRTHTGEIP-YECNECGKAFKYSSSLTKHMRIHTGEKPFECNECGK 483

  Fly   348 A 348
            |
Human   484 A 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	6/19 (32%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..308	CDD:275368	13/48 (27%)
		C2H2 Zn finger	288..303	CDD:275370	3/14 (21%)
		zf-C2H2	315..337	CDD:278523	8/21 (38%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
ZFP37	NP_001269444.1	KRAB	47..106	CDD:214630
		KRAB	47..86	CDD:279668
		COG5048	288..>633	CDD:227381	59/212 (28%)
		C2H2 Zn finger	310..330	CDD:275368	6/19 (32%)
		C2H2 Zn finger	338..358	CDD:275368	6/19 (32%)
		zf-H2C2_2	350..372	CDD:290200	7/21 (33%)
		C2H2 Zn finger	366..386	CDD:275368	6/19 (32%)
		zf-H2C2_2	378..403	CDD:290200	8/24 (33%)
		C2H2 Zn finger	394..414	CDD:275368	6/19 (32%)
		zf-H2C2_2	406..431	CDD:290200	6/25 (24%)
		C2H2 Zn finger	422..442	CDD:275368	5/19 (26%)
		zf-H2C2_2	434..459	CDD:290200	10/25 (40%)
		zf-C2H2	448..470	CDD:278523	8/21 (38%)
		C2H2 Zn finger	450..470	CDD:275368	7/19 (37%)
		zf-H2C2_2	462..486	CDD:290200	8/23 (35%)
		C2H2 Zn finger	478..498	CDD:275368	2/7 (29%)
		zf-H2C2_2	490..513	CDD:290200
		C2H2 Zn finger	506..526	CDD:275368
		zf-H2C2_2	518..543	CDD:290200
		C2H2 Zn finger	534..554	CDD:275368
		zf-H2C2_2	547..571	CDD:290200
		C2H2 Zn finger	562..582	CDD:275368
		zf-H2C2_2	574..598	CDD:290200
		C2H2 Zn finger	590..610	CDD:275368
		zf-H2C2_2	603..627	CDD:290200
		C2H2 Zn finger	618..638	CDD:275368

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000