DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sry-beta and ZNF250

DIOPT Version :10

Sequence 1:NP_524579.1 Gene:Sry-beta / 43570 FlyBaseID:FBgn0003511 Length:356 Species:Drosophila melanogaster
Sequence 2:NP_066405.1 Gene:ZNF250 / 58500 HGNCID:13044 Length:560 Species:Homo sapiens


Alignment Length:973 Identity:183/973 - (18%)
Similarity:290/973 - (29%) Gaps:373/973 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 NSYDTRSEASGDGDADEPDADEADGS---HPS-ISSVSS--AESDSVGTDLEEENND--DDGDGG 80
            |...|...|...|..|.|...|:..:   ||. :.:..|  ||.:.:.:.:..|.:.  ||    
Human     9 NELYTLKVAMKSGTPDAPTTQESLKAVLLHPQPLGATKSFPAEVEMINSKVGNEFSHLCDD---- 69

  Fly    81 ASGKKKKGDAKPTPKQENGAAKGKETTKKKTKKAAADKTDGDNAKEEEEEEDDDDDEENDAKEDE 145
                .:|.:...|..|:.....|....|:|:::|.....                  :|..||::
Human    70 ----SQKQEKDMTGNQQEQEKSGVVRKKRKSQQAGPSYV------------------QNCVKENQ 112

  Fly   146 E------ELDDPMEEDDDDDDDE----------EEEDDDEEEDDDEEEQGRRSNK-RTKKTKASS 193
            |      :|:.|.:||:|....|          ....|....|:|:|...|.:.. .:.|:::.|
Human   113 EILGRRQQLETPSDEDNDSSLSECLSSPSSSLHFGGSDTVTSDEDKEVSVRHTQPVLSAKSRSHS 177

  Fly   194 AKGGAAGKKKVVAKKAAVAKQPPKKKAKTAATTTPTAAEKK-----EGAEKPTAAEKKKKKAATG 253
            |:.                    .|..:|.|...|:...|:     ....:.|..::..|.:::.
Human   178 ARS--------------------HKWPRTEADPVPSLLMKRPCFHGSALRRVTCRKRLVKSSSSQ 222

  Fly   254 ASQDGKKSAGKKKEDKESAAGGASNGPEEKEDAANNSTNNANDTSTSSSSSSSSSSSSSEAGSKK 318
            .:|..|:....:::.:|:.|        :::.|..:|::::::...||.||||||:...|     
Human   223 RTQKQKERMLVQRKKREALA--------QRKYALLSSSSSSSENDLSSDSSSSSSTDGEE----- 274

  Fly   319 DGRKSRSRSPAS-GAPEAKRSRTKAAGNAAGTKNTVKSYDY-VTKINYLFREARFFLIKSNNHDN 381
            |...|.|.:|:: .||............|:.|.....:.:. ||..:   .|.....:..:....
Human   275 DLCASASENPSNPAAPSGSIDEDVVVIEASFTPQVTANEEINVTSTD---SEVEIVTVGESYRSR 336

  Fly   382 VALSKSKGVWSTLPPNEANLNQAFRESRNVILLFSVKESGKFAGFARMGAEARRDLPAVDWVLPP 446
            ..|..|:..||....:.....|   ||||...:.:|.:.      .|..|....|| .||     
Human   337 STLGHSRSHWSQGSSSHTGRPQ---ESRNRSRISTVIQP------LRQNAAEVVDL-TVD----- 386

  Fly   447 GMSAKALGGVIKIDWVCKKELPFTSTSHLYNAWNDDKPVKIGRDGQEIEPKVAEELCRLFTEDTG 511
                                              :|:|.        |.|..:..:....|..:.
Human   387 ----------------------------------EDEPT--------IVPTTSARMDSQTTSASI 409

  Fly   512 IDMTPILKKSKEASKLMKEKAASKSFRRPPNFGRPTSSSSGLRSRSSGGSGGGGGSGGIGPIRRG 576
            .:..|  ..|::||......|:|:     |:....|.::  |.|.|:.||..|      ..:||.
Human   410 NNSNP--STSEQASDTTSTVASSQ-----PSTVSETEAT--LTSNSATGSSVG------DDVRRT 459

  Fly   577 GRRMYP-----------------GPRGGRDGGGGGGGGGGGGSRSHGG-----SSMFAP----YR 615
            .....|                 .|.||.             |:||..     ||.|..    ::
Human   460 ASSAVPESGPPAMPRLPSCCPQHSPCGGT-------------SQSHHALAHPHSSCFQQHGHHFQ 511

  Fly   616 KDRHGGGGMGGGSRHGGHGGGGMGPRM----------------GMGGGSG--------------- 649
            ...|        ..|..|....:.|..                |....||               
Human   512 HHHH--------HHHTPHPAVPVSPSFSDPACPVERPQVQAPCGANSSSGSSYHDQQALPVDLSN 568

  Fly   650 ------GDGGDRGGGGM--------SRAAAFGAMHHPAHHHRWA---------DGYSSTAAAEAY 691
                  |.||..|....        ||||.||        |:.|         |||.|:..|:. 
Human   569 SALRTHGSGGFHGASAFDPCCPVTSSRAAVFG--------HQAAAAPTQPLSIDGYGSSMVAQP- 624

  Fly   692 VADYMRNMQNQLPPMP-------YAPPPGFPAMPLP-----------YDNMPP---PPRYYDGLP 735
                    |.|.||.|       |.||| :.::..|           :.|.||   ||      |
Human   625 --------QPQPPPQPSLSSCRHYMPPP-YASLTRPLHHQASACHHSHGNAPPQTQPP------P 674

  Fly   736 IPEYQLP------PGSIPGSVTGAGGMPPPRSHAATAAAAAAIYDKRAAVGGLVGGLATMKGPPP 794
            ..:|.:|      ...|..........|||.:|..:.||..                     |..
Human   675 QVDYVIPHPVHAFHSQISSHAASHPVAPPPPTHLGSTAAPI---------------------PQH 718

  Fly   795 VLPSH---GYHVPPP----------------------MI---------PPMHHHHMHRKNDRG 823
            :.|:|   .:|:|.|                      |:         ||.|.|.||.....|
Human   719 LPPAHQPISHHIPAPAPSAQRLHPHEVMQRMEVQRRRMMQHPTRAHERPPPHPHRMHPNYGHG 781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sry-betaNP_524579.1 C2H2 Zn finger 203..223 CDD:275368 1/19 (5%)
C2H2 Zn finger 231..251 CDD:275368 3/24 (13%)
C2H2 Zn finger 259..308 CDD:275368 11/48 (23%)
C2H2 Zn finger 288..303 CDD:275370 3/14 (21%)
zf-C2H2 315..337 CDD:395048 6/22 (27%)
C2H2 Zn finger 317..337 CDD:275368 6/20 (30%)
ZNF250NP_066405.1 KRAB 22..82 CDD:214630 13/67 (19%)
COG5048 178..537 CDD:227381 85/487 (17%)
C2H2 Zn finger 201..221 CDD:275368 2/19 (11%)
C2H2 Zn finger 229..249 CDD:275368 3/27 (11%)
C2H2 Zn finger 257..277 CDD:275368 10/24 (42%)
C2H2 Zn finger 285..305 CDD:275368 3/19 (16%)
C2H2 Zn finger 313..333 CDD:275368 3/22 (14%)
C2H2 Zn finger 341..361 CDD:275368 5/22 (23%)
C2H2 Zn finger 369..389 CDD:275368 7/65 (11%)
C2H2 Zn finger 397..417 CDD:275368 2/21 (10%)
C2H2 Zn finger 425..445 CDD:275368 5/26 (19%)
C2H2 Zn finger 453..473 CDD:275368 4/25 (16%)
C2H2 Zn finger 481..501 CDD:275368 6/32 (19%)
C2H2 Zn finger 509..529 CDD:275368 3/27 (11%)
C2H2 Zn finger 537..557 CDD:275368 3/19 (16%)

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