DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and ZNF630

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_001032824.2	Gene:	ZNF630 / 57232	HGNCID:	28855	Length:	657	Species:	Homo sapiens

Alignment Length:	381	Identity:	96/381 - (25%)
Similarity:	146/381 - (38%)	Gaps:	68/381 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CFVCGKEKSVGVFQLIEGCIVPGTFKPIKDILKYFEKIINQRLELLPNSAACRDCLEYLFNYDRL 72
            |.:|||.                       .:|..:.||:||:........|.||.:.......|
Human   265 CSMCGKA-----------------------FIKKSQLIIHQRIHTGEKPYVCGDCRKAFSEKSHL 306

  Fly    73 VRNLSQVQRQI--ADALLGCRQVEGKAETKQ------QAAKRARVQVPAFKIVQATALK------ 123
            :     |.::|  .:....|.:. |:|.:::      |...........|:..:|.:.|
Human   307 I-----VHQRIHTGEKPYECTKY-GRAFSRKSPFTVHQRVHTGEKPYECFECPKAFSQKSHLIIH 365

  Fly   124 ---EPERQPGEEDECEE-FMKEEML---------DEEFQFSEPDDSMPSSEEEFF---TETTEIP 172
               ....:|.|..||.: |.:...|         .:.::.:|...:.|...:...   |.|.|.|
Human   366 QRVHTREKPFECSECRKAFCEMSHLFIHQITHTGKKPYECTECGKTFPRKTQLIIHQRTHTGEKP 430

  Fly   173 --CHICGEMFSSQEVLERHIKADTCQKSEQATCNVCGLKVKDDEVLDLHMNLHEGKTELECRYCD 235
              |..||:.|..|..|..|.:..|.:|  ...|..||........|..|..||.|:....|..|.
Human   431 YKCGECGKTFCQQSHLIGHQRIHTGEK--PYVCTDCGKAFSQKSHLTGHQRLHTGEKPYMCTECG 493

  Fly   236 KKFSHKRNVLRHMEVHWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENALICEVCHQQFKTKRT 300
            |.||.|..::.|..:|..:|.|||.:||:.||...|:..||..|..|: ...|..|.:.|..|..
Human   494 KSFSQKSPLIIHQRIHTGEKPYQCGECGKTFSQKSLLIIHLRVHTGEK-PYECTECGRAFSLKSH 557

  Fly   301 YKHHLRTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVHQPVEKPESAEAKEATVTFF 356
            ...|.|.|..::| |.|.:|.|:|..|..|.:|::.|...:.||.|   |:.:|||
Human   558 LILHQRGHTGEKP-YECSECGKAFCGKSPLIIHQKTHPREKTPECA---ESGMTFF 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		C2H2 Zn finger	231..251	CDD:275368	7/19 (37%)
		C2H2 Zn finger	259..308	CDD:275368	16/48 (33%)
		C2H2 Zn finger	288..303	CDD:275370	4/14 (29%)
		zf-C2H2	315..337	CDD:278523	8/21 (38%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
ZNF630	NP_001032824.2	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	238..257	CDD:275368
		C2H2 Zn finger	265..285	CDD:275368	9/42 (21%)
		C2H2 Zn finger	293..313	CDD:275368	5/24 (21%)
		zf-H2C2_2	305..330	CDD:290200	6/30 (20%)
		C2H2 Zn finger	321..341	CDD:275368	4/20 (20%)
		COG5048	<329..578	CDD:227381	65/252 (26%)
		zf-H2C2_2	336..358	CDD:290200	3/21 (14%)
		C2H2 Zn finger	349..369	CDD:275368	3/19 (16%)
		C2H2 Zn finger	377..397	CDD:275368	4/19 (21%)
		zf-H2C2_2	389..412	CDD:290200	2/22 (9%)
		C2H2 Zn finger	405..425	CDD:275368	2/19 (11%)
		zf-H2C2_2	418..440	CDD:290200	7/21 (33%)
		C2H2 Zn finger	433..453	CDD:275368	7/19 (37%)
		zf-H2C2_2	449..470	CDD:290200	6/22 (27%)
		C2H2 Zn finger	461..481	CDD:275368	5/19 (26%)
		zf-H2C2_2	473..498	CDD:290200	9/24 (38%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		zf-H2C2_2	502..526	CDD:290200	9/23 (39%)
		C2H2 Zn finger	517..537	CDD:275368	8/19 (42%)
		zf-H2C2_2	530..553	CDD:290200	6/23 (26%)
		C2H2 Zn finger	545..565	CDD:275368	6/19 (32%)
		zf-H2C2_2	557..580	CDD:290200	8/23 (35%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	601..620	CDD:275370	5/12 (42%)
		C2H2 Zn finger	629..646	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000