DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sry-beta and si:ch211-222k6.2

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_001373745.1	Gene:	si:ch211-222k6.2 / 556142	ZFINID:	ZDB-GENE-030131-9038	Length:	364	Species:	Danio rerio

Alignment Length:	288	Identity:	76/288 - (26%)
Similarity:	123/288 - (42%)	Gaps:	44/288 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 NLSQVQRQIADALLGCRQVEGKAETKQQAAKRARVQVPAFKIVQATALKEPE-----RQPGEEDE 134
            :|.:..||..:.|        :|..|.|.....:...|:|:       ..||     .|.|:...
Zfish    19 DLMEENRQTGELL--------EAVEKHQDTHGQKSMSPSFQ-------SRPEVHFTCPQCGKSFS 68

  Fly   135 CEEFMKEEMLDEEFQFSEPDDSMPSSE-EEFFTETTEI-------------PCHICGEMFSSQEV 185
            |::.:...|     :|..........: ::.||..|.:             .|..||.:|:.:..
Zfish    69 CDQSLNLHM-----KFHRGTKPYACDQCDKIFTLKTNLNEHMKIHTAKMLYTCGQCGTIFTDEGN 128

  Fly   186 LERHIKADTCQKSEQATCNVCGLKVKDDEVLDLHMNLHEGKTELECRYCDKKFSHKRNVLRHMEV 250
            |..|:|:...:.  ..||..||.:.......:.||.:|.|:....|..|.|:|:||.|:.:|:.|
Zfish   129 LNEHMKSHVVEM--PFTCGHCGKRFTYKGNFNEHMKIHTGERPYACDQCGKRFTHKGNLNKHIIV 191

  Fly   251 HWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENALICEVCHQQFKTKRTYKHHLRTHQTDRPRY 315
            |..:|.:.||:||::|.|..::.:|:..|.. |...:|:.|...|:...|::.|||.|...|| :
Zfish   192 HTGEKPHSCDQCGKKFKLKHILNDHMKIHTG-EMPYMCDQCGTSFRKLDTFRLHLRYHSGVRP-F 254

  Fly   316 PCPDCEKSFVDKYTLKVHKRVHQPVEKP 343
            .|..|.|.|.....||.|.:||..| ||
Zfish   255 SCDQCGKHFFTSVALKYHVKVHAKV-KP 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		C2H2 Zn finger	231..251	CDD:275368	8/19 (42%)
		C2H2 Zn finger	259..308	CDD:275368	16/48 (33%)
		C2H2 Zn finger	288..303	CDD:275370	4/14 (29%)
		zf-C2H2	315..337	CDD:278523	7/21 (33%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
si:ch211-222k6.2	NP_001373745.1	C2H2 Zn finger	144..164	CDD:275368	5/19 (26%)
		C2H2 Zn finger	172..192	CDD:275368	8/19 (42%)
		C2H2 Zn finger	200..220	CDD:275368	7/19 (37%)
		C2H2 Zn finger	228..248	CDD:275368	7/19 (37%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		C2H2 Zn finger	284..304	CDD:275368
		C2H2 Zn finger	312..332	CDD:275368
		C2H2 Zn finger	340..360	CDD:275368
		COG5048	37..>362	CDD:227381	70/262 (27%)
		C2H2 Zn finger	60..80	CDD:275368	4/24 (17%)
		C2H2 Zn finger	88..108	CDD:275368	3/19 (16%)
		C2H2 Zn finger	116..136	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910