DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and si:dkey-262g12.9

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	XP_021331485.1	Gene:	si:dkey-262g12.9 / 555910	ZFINID:	ZDB-GENE-161017-28	Length:	380	Species:	Danio rerio

Alignment Length:	252	Identity:	68/252 - (26%)
Similarity:	107/252 - (42%)	Gaps:	37/252 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 LKEPERQPGEEDECEEFMK-EEMLDEEFQFSEPDDSMPSSEEEFFTETTEIPCHICGEMFSSQEV 185
            :||...:..|.:|.::|.| :|::.||.. :|...:.|....:.........|...|..|:.:..
Zfish    32 MKEESEELNETEEKDQFEKHQELMTEEIS-AETKKASPHKRAQKTKSDGNFTCSQGGMSFTQKNN 95

  Fly   186 LERHIKADTCQKSEQA--TCNVCGLKVKDDEVLDLHMNLHEGKTELECRYCDKKFSHKRNVLRHM 248
            |..|:.|    :||:.  .|..||...:...:|.:||.:|.|:....|..|.|.|:.::|:..|.
Zfish    96 LVDHMSA----RSEEKPYPCPECGKGFRKKHILAVHMRVHTGEKPFSCDLCGKSFNLQKNMKIHR 156

  Fly   249 EVHWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENALICEVCHQQFKTKRTYKHHLRTHQTDRP 313
            .:|..::.|.|.:||:||....::.||:..|.. |....|..|...|..|:..:.|:..|.|:||
Zfish   157 RIHTGERPYACQQCGKRFRQIQILKNHIKLHTG-ERPYACAQCGMSFIQKQKLEAHMAVHNTERP 220

  Fly   314 ---------------------------RYPCPDCEKSFVDKYTLKVHKRVHQPVEKP 343
                                       .:.|..|.|||..:..||||.|||.. |||
Zfish   221 FACHQCGGNFAHKDYLTIHMKIHSGEKPFACQQCGKSFNRRQCLKVHMRVHTG-EKP 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	6/19 (32%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..308	CDD:275368	14/48 (29%)
		C2H2 Zn finger	288..303	CDD:275370	4/14 (29%)
		zf-C2H2	315..337	CDD:278523	10/21 (48%)
		C2H2 Zn finger	317..337	CDD:275368	10/19 (53%)
si:dkey-262g12.9	XP_021331485.1	COG5048	<75..263	CDD:227381	47/192 (24%)
		C2H2 Zn finger	83..103	CDD:275368	6/23 (26%)
		C2H2 Zn finger	111..131	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		C2H2 Zn finger	195..215	CDD:275368	5/19 (26%)
		COG5048	216..>328	CDD:227381	18/62 (29%)
		C2H2 Zn finger	223..243	CDD:275368	0/19 (0%)
		C2H2 Zn finger	251..271	CDD:275368	10/19 (53%)
		C2H2 Zn finger	279..299	CDD:275368
		C2H2 Zn finger	307..327	CDD:275368
		C2H2 Zn finger	335..355	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910