DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sry-beta and Sry-delta

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_524581.1	Gene:	Sry-delta / 43572	FlyBaseID:	FBgn0003512	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	401	Identity:	133/401 - (33%)
Similarity:	203/401 - (50%)	Gaps:	64/401 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CFVCGK-------EKSVGVFQLIEGCIVPGTFKPIKDILKYFEKIINQRLELLPNSAACRDCLEY 65
            ||.||.       ..|...::.: ...||.:.|.:..:|.:....|..:|:|.|.:..|..|.:.
  Fly     4 CFFCGAVDLSDTGSSSSMRYETL-SAKVPSSQKTVSLVLTHLANCIQTQLDLKPGARLCPRCFQE 67

  Fly    66 LFNYDRLVRNLSQVQRQIADALLGCRQVEGKAETKQQAAKRARVQVPAFKI-----VQATALKEP 125
            |.:||.::.||...|:::...|.|..:.|.:.....:......|::|...:     .:|.||...
  Fly    68 LSDYDTIMVNLMTTQKRLTTQLKGALKSEFEVPESGEDILVEEVEIPQSDVETDADAEADALFVE 132

  Fly   126 ERQPGEEDECEEFMKEEMLDEEFQFSEPDDSMPSSEEEFFTETTEI------------------- 171
            ..:..||.:.|  :|.|.:|||.:..:.||      :||..|..::
  Fly   133 LVKDQEESDTE--IKREFVDEEEEEDDDDD------DEFICEDVDVGDSEALYGKSSDGEDRPTK 189

  Fly   172 -----PCHICGEMFSSQEVLERHIKADTCQKSEQATCNVCGLKVKDDEVLDLHMNLHEGKTELEC 231
                 .|..||::::|...|::|| ::...|.....|.:||:..:|:|.|:|||||||||||.:|
  Fly   190 KRVKQECTTCGKVYNSWYQLQKHI-SEEHSKQPNHICPICGVIRRDEEYLELHMNLHEGKTEKQC 253

  Fly   232 RYCDKKFSHKRNVLRHMEVHWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENALICEVCHQQFK 296
            |||.|.||...|.||||.:|||||||||:|||.|||...|:|||.:||:||||.:||.:|:..||
  Fly   254 RYCPKSFSRPVNTLRHMRMHWDKKKYQCEKCGLRFSQDNLLYNHRLRHEAEENPIICSICNVSFK 318

  Fly   297 TKRTYKHHLRTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVHQ-----------PVEKPESAE--- 347
            :::|:.||...|:.:|||:.|..|.|||.::||||:|.:.|:           |.::.:..|
  Fly   319 SRKTFNHHTLIHKENRPRHYCSVCPKSFTERYTLKMHMKTHEGDVVYGVREEAPADEQQVVEELH 383

  Fly   348 ----AKEATVT 354
                ..||.||
  Fly   384 VDVDESEAAVT 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	10/19 (53%)
		C2H2 Zn finger	231..251	CDD:275368	12/19 (63%)
		C2H2 Zn finger	259..308	CDD:275368	25/48 (52%)
		C2H2 Zn finger	288..303	CDD:275370	5/14 (36%)
		zf-C2H2	315..337	CDD:278523	10/21 (48%)
		C2H2 Zn finger	317..337	CDD:275368	10/19 (53%)
Sry-delta	NP_524581.1	COG5048	<205..360	CDD:227381	81/155 (52%)
		C2H2 Zn finger	225..245	CDD:275368	10/19 (53%)
		C2H2 Zn finger	253..273	CDD:275368	12/19 (63%)
		C2H2 Zn finger	281..301	CDD:275368	11/19 (58%)
		C2H2 Zn finger	310..327	CDD:275370	6/16 (38%)
		zf-C2H2	337..359	CDD:278523	10/21 (48%)
		C2H2 Zn finger	339..359	CDD:275368	10/19 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11996
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0019947
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010