DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sry-beta and topi

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	328	Identity:	76/328 - (23%)
Similarity:	116/328 - (35%)	Gaps:	103/328 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 ATALKEPERQ-PGEEDECEEFM--KEEMLDEEFQFSEPDDSMPSSEEEFFTET---TEIPCHICG 177
            :|..:.|..| |....:..|.:  .|.::|.:..|:..:.:....::|.|:..   :.:.|..|.
  Fly   302 STMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCE 366

  Fly   178 EMF---------SSQEVLERHIKADTCQ------------------------------KSEQATC 203
            .:|         |:..|.||..:...|.                              .|....|
  Fly   367 YIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVC 431

  Fly   204 NVCGLKVKDDEVLDLH----------MNLHEGKTELECRYCDKKFSHKRNVLRHM-EVHWDKKK- 256
            |||.||..:.::|..|          :|.:..|..|.|.:||..|....:.|.|. |.|.:|||
  Fly   432 NVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKR 496

  Fly   257 --------------YQCDKCGERFSLSWLMYNHLMRHDA-------EENA--------------- 285
                          |.||.||:.::.|..::.||..|..       |||.
  Fly   497 EKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIR 561

  Fly   286 --------LICEVCHQQFKTKRTYKHHLRTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVHQPVEK 342
                    .:|.||.::|.|...:..|...|:.:| ||.|.:|.|.|.....||.|:|:|.. ||
  Fly   562 KCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGER-RYECEECGKRFYRADALKNHQRIHTG-EK 624

  Fly   343 PES 345
            |.|
  Fly   625 PYS 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	9/29 (31%)
		C2H2 Zn finger	231..251	CDD:275368	7/20 (35%)
		C2H2 Zn finger	259..308	CDD:275368	17/78 (22%)
		C2H2 Zn finger	288..303	CDD:275370	5/14 (36%)
		zf-C2H2	315..337	CDD:278523	9/21 (43%)
		C2H2 Zn finger	317..337	CDD:275368	8/19 (42%)
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	431..453	CDD:275368	8/21 (38%)
		COG5048	<450..647	CDD:227381	49/180 (27%)
		C2H2 Zn finger	469..490	CDD:275368	7/20 (35%)
		zf-C2H2	511..533	CDD:278523	8/21 (38%)
		C2H2 Zn finger	513..564	CDD:275368	11/50 (22%)
		C2H2 Zn finger	541..561	CDD:275368	3/19 (16%)
		zf-H2C2_2	555..581	CDD:290200	4/25 (16%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		zf-H2C2_2	585..609	CDD:290200	9/24 (38%)
		zf-C2H2	598..620	CDD:278523	9/21 (43%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:290200	9/17 (53%)
		C2H2 Zn finger	628..646	CDD:275368	76/328 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446670
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840