DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and Neu2

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster

Alignment Length:	262	Identity:	64/262 - (24%)
Similarity:	96/262 - (36%)	Gaps:	59/262 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 AFKIVQATALKEPERQPGEEDECEEFMKE--------EMLDEEFQF-----------SEPDDSMP 158
            |:.|.:.|..:..:..|.....|:..:::        |..:...||           ||.|.|..
  Fly    16 AYIIYKCTGWQVEKHDPLSNTICKSCLEDAQNAFDIIETYERSHQFYRFLKDVREEESENDGSGC 80

  Fly   159 SSEEEFFTETTEIPCHICGEMFSSQEVLERHIK--ADTCQKSEQATCNVCGLKVKD--------- 212
            |.|                     .|..||.::  ||......:...|.|.:|.|:
  Fly    81 SEE---------------------VEAAERDLQDGADDVDSGNEPDINECDIKAKEKPGFSCSHC 124

  Fly   213 ------DEVLDLHMNLHEGKTELECRYCDKKFSHKRNVLRHMEVHWDKKKYQCDKCGERFSLSWL 271
                  ...|.:||..|.|:....|..|.|.|.:...:..||..|..::.:||..|...|:....
  Fly   125 PKSFQVKSNLKVHMRSHTGERPFTCSLCPKSFGYSSGLQNHMRTHTGERPFQCSHCPRSFTAGHH 189

  Fly   272 MYNHLMRHDAEENALICEVCHQQFKTKRTYKHHLRTHQTDRPRYPCPDCEKSFVDKYTLKVHKRV 336
            :..|:..|: ...:|.|..|.:.|.|....|.||.|| ||..::.|..|.|||..::.|.:|.||
  Fly   190 LKAHIQMHE-RRGSLRCPYCQKCFLTSLILKQHLATH-TDETQFKCSQCSKSFQVEHELWMHMRV 252

  Fly   337 HQ 338
            ||
  Fly   253 HQ 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	7/34 (21%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..308	CDD:275368	13/48 (27%)
		C2H2 Zn finger	288..303	CDD:275370	4/14 (29%)
		zf-C2H2	315..337	CDD:278523	8/21 (38%)
		C2H2 Zn finger	317..337	CDD:275368	8/19 (42%)
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071	8/46 (17%)
		COG5048	<119..241	CDD:227381	34/123 (28%)
		C2H2 Zn finger	121..141	CDD:275368	3/19 (16%)
		zf-H2C2_2	133..158	CDD:290200	9/24 (38%)
		C2H2 Zn finger	149..169	CDD:275368	6/19 (32%)
		zf-H2C2_2	162..185	CDD:290200	6/22 (27%)
		C2H2 Zn finger	177..197	CDD:275368	4/19 (21%)
		C2H2 Zn finger	205..225	CDD:275368	7/19 (37%)
		zf-C2H2_8	206..286	CDD:292531	21/50 (42%)
		C2H2 Zn finger	233..253	CDD:275368	8/19 (42%)
		C2H2 Zn finger	260..297	CDD:275368
		C2H2 Zn finger	303..323	CDD:275368
		C2H2 Zn finger	353..373	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446571
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030