DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and ZNF808

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_001034975.2	Gene:	ZNF808 / 388558	HGNCID:	33230	Length:	903	Species:	Homo sapiens

Alignment Length:	368	Identity:	78/368 - (21%)
Similarity:	138/368 - (37%)	Gaps:	98/368 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 KPIKDIL--KYFEKIINQRLELLPNSAACRDCLEYLFNYDRLVRNLSQVQRQIADALLGCRQVEG 95
            |||||.|  .::..        ||..        ::|.....:.|  |:::..:||        .
Human   150 KPIKDQLGSSFYSH--------LPEL--------HIFQIKGEIAN--QLEKSTSDA--------S 188

  Fly    96 KAETKQQAAKRARVQV--------------PAFKIVQATALKEPERQPGEEDECEEFMKEEML-- 144
            ...|.|:.:.|.::.:              |..:.|.......|..:.|:...|...:::..:
Human   189 SVSTSQRISCRPQIHISNNYGNNPLNSSLLPQKQEVHMREKSFPCNESGKAFNCSSLLRKHQIPH 253

  Fly   145 --DEEFQFSEPDDSMPSSEEEFFTETTEIPCHICGEMFSSQEVL---------ERHIKADTCQKS 198
              |::::                       |.:||::|:.::.|         |:..|...|.||
Human   254 LGDKQYK-----------------------CDVCGKLFNHKQYLACHRRCHTGEKPYKCKECGKS 295

  Fly   199 -----------------EQATCNVCGLKVKDDEVLDLHMNLHEGKTELECRYCDKKFSHKRNVLR 246
                             :...||.||...:.:..|.:|..:|.|:...:|..|.|.|:.:.::.|
Human   296 FSYKSSLTCHHRLHTGVKPYKCNECGKVFRQNSALVIHKAIHTGEKPYKCNECGKAFNQQSHLSR 360

  Fly   247 HMEVHWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENALICEVCHQQFKTKRTYKHHLRTHQTD 311
            |..:|...|.|:|..|.:.|:....:.||...|..|: ...|..|.:.|..:.:...|...|..:
Human   361 HQRLHTGVKPYKCKICEKAFACHSYLANHTRIHSGEK-TYKCNECGKAFNHQSSLARHHILHTGE 424

  Fly   312 RPRYPCPDCEKSFVDKYTLKVHKRVHQPVEKPESAEAKEATVT 354
            :| |.|.:|:|.|..|.||:.|||:|.. |||...:..:...|
Human   425 KP-YKCEECDKVFSQKSTLERHKRIHTG-EKPYKCKVCDTAFT 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	6/19 (32%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..308	CDD:275368	11/48 (23%)
		C2H2 Zn finger	288..303	CDD:275370	3/14 (21%)
		zf-C2H2	315..337	CDD:278523	11/21 (52%)
		C2H2 Zn finger	317..337	CDD:275368	10/19 (53%)
ZNF808	NP_001034975.2	KRAB	24..64	CDD:307490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..154		3/3 (100%)
		COG5048	206..585	CDD:227381	62/286 (22%)
		C2H2 Zn finger	233..253	CDD:275368	2/19 (11%)
		C2H2 Zn finger	261..281	CDD:275368	5/19 (26%)
		C2H2 Zn finger	289..309	CDD:275368	3/19 (16%)
		C2H2 Zn finger	317..337	CDD:275368	6/19 (32%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		C2H2 Zn finger	373..393	CDD:275368	5/19 (26%)
		COG5048	397..839	CDD:227381	22/72 (31%)
		C2H2 Zn finger	401..421	CDD:275368	4/19 (21%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	1/9 (11%)
		C2H2 Zn finger	485..505	CDD:275368
		C2H2 Zn finger	513..533	CDD:275368
		C2H2 Zn finger	541..561	CDD:275368
		C2H2 Zn finger	569..589	CDD:275368
		C2H2 Zn finger	597..617	CDD:275368
		C2H2 Zn finger	625..645	CDD:275368
		C2H2 Zn finger	653..673	CDD:275368
		C2H2 Zn finger	681..701	CDD:275368
		C2H2 Zn finger	709..729	CDD:275368
		C2H2 Zn finger	737..757	CDD:275368
		C2H2 Zn finger	765..785	CDD:275368
		C2H2 Zn finger	793..813	CDD:275368
		SFP1	<816..893	CDD:227516
		C2H2 Zn finger	821..841	CDD:275368
		C2H2 Zn finger	849..869	CDD:275368
		C2H2 Zn finger	877..897	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000