DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and CG7386

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	368	Identity:	86/368 - (23%)
Similarity:	145/368 - (39%)	Gaps:	77/368 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VGVFQLI-------EGCIVPGTFKPIKDILKYFEKIINQRLELLPNSAACRDCLEYLFNYDRLVR 74
            :|||:.|       |....|.:|.|          ::|.:||::.|.   .|..:.|   :::.:
  Fly    91 MGVFESIADDSEAPERPEEPASFDP----------LLNNKLEMIDNE---EDVFKLL---EKVDK 139

  Fly    75 NLSQVQRQIADALLGCRQVEGKAETK----------QQAAKRARVQVPAFKIVQATALKEPERQP 129
            .|.:..|..::......:..|..|.|          :||..:.|:.....|:.:..:....:::.
  Fly   140 ELEEHSRDQSEEHFSSAEHNGLEEEKKESEGFNSDDEQAMGQRRIANDKRKLFRLMSCSICQQKF 204

  Fly   130 GEEDECEEFMKEEMLDEEFQFSEPD---------------DSMPSSEEEFFTETTEIPCHI--CG 177
            .::.:.||.||.......||..|..               |...|.:|:      .:||.:  |.
  Fly   205 KKQSKFEEHMKHHNDLLPFQCQEESCRKGFTTAGALRLHVDYAHSKKED------TVPCTVEGCQ 263

  Fly   178 EMFSSQEVLERHIKADTCQ------KSEQATCNVCGLKVKDDEVLDLHMNLHEGKTEL--ECRYC 234
            .:||...:|..|:|....|      :.|| :|..||:..:....:..||..|.|: ||  .|..|
  Fly   264 LVFSRLRLLTIHLKKVHNQARVIAPRGEQ-SCKECGVVFRCPVAMKKHMYTHTGE-ELPYPCTIC 326

  Fly   235 DKKF----SHKRNVLRHMEVHWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENALICEVCHQQF 295
            .|.|    :.|.::|||..:    |.|.|..||.|.:.......|::.| .:.|...|.:|....
  Fly   327 GKGFYINSALKNHLLRHAGI----KNYVCQYCGVRKTTRQEWSKHILIH-TQRNQFKCRICDYAT 386

  Fly   296 KTKRTYKHHLR-THQTDRPRYPCPDCEKSFVDKYTLKVHKRVH 337
            .|||..:.|:: .|:..| .:.|..|.|:|...|..|:|:..|
  Fly   387 HTKRVLESHVKIVHEKIR-NFACQYCGKTFGKAYACKIHEMAH 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		C2H2 Zn finger	231..251	CDD:275368	8/23 (35%)
		C2H2 Zn finger	259..308	CDD:275368	13/49 (27%)
		C2H2 Zn finger	288..303	CDD:275370	5/14 (36%)
		zf-C2H2	315..337	CDD:278523	7/21 (33%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871
		C2H2 Zn finger	197..217	CDD:275368	4/19 (21%)
		C2H2 Zn finger	294..314	CDD:275368	5/19 (26%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..371	CDD:275368	5/19 (26%)
		C2H2 Zn finger	379..400	CDD:275368	6/20 (30%)
		C2H2 Zn finger	408..428	CDD:275368	7/19 (37%)
		C2H2 Zn finger	436..456	CDD:275368
		C2H2 Zn finger	534..555	CDD:275368
		C2H2 Zn finger	563..583	CDD:275368
		zf-H2C2_2	575..600	CDD:290200
		C2H2 Zn finger	591..611	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449772
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930