DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and CG10274

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster

Alignment Length:	368	Identity:	84/368 - (22%)
Similarity:	146/368 - (39%)	Gaps:	88/368 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 FEKIINQRLELLPNSAACRDCLEYLFNYDRLVRNLSQVQRQI------ADALLGCRQVEGKAETK 100
            |:.:::.::|::.|.   .|..:.|.:.|   :...||::::      |..|:.....|...|::
  Fly   131 FDPLLDHKMEMIENE---EDVFKMLEHVD---KEAEQVEKEVKQDELDAADLMTIFAAESSEESE 189

  Fly   101 QQ-------------------AAKRARVQVPAFKIVQATALKEPERQ--PGEEDECEEFMKEEML 144
            :.                   .|:|.|.........:|..:||.:::  .|.|:|.|:..|.:..
  Fly   190 EDIDQDVDFEPNSSDGDDDVPLAQRLRDNSRMIPKAKAAVIKEEDQEFPTGSEEEDEDGEKSKSR 254

  Fly   145 DEEFQFSEPDDSMPSSEEEFFTETTEIPCHICGEMFSSQEVLERHI-----------KADTCQK- 197
            .:.         :|..|....   ..|.||||.:.|......|.|:           |.:||:|
  Fly   255 RKR---------IPPGERHLH---RIIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCKVETCRKG 307

  Fly   198 ------------------SEQATCNV--CGLKVKDDEVLDLHMNLHEGKT-------ELECRYCD 235
                              ||..:|||  ||.......:|..||....|.|       :..|..|:
  Fly   308 FTTAGGLRLHIDHAHTELSEVHSCNVDGCGKTFPRIRLLTFHMKKMHGITKAAAPPRDYPCTECE 372

  Fly   236 KKFSHKRNVLRHMEVHWDKK-KYQCDKCGERFSLSWLMYNHLMRHDAEENALICEVCHQQFKTKR 299
            |.|.....:.:||..|..|: .:.|:.||:||.::..:.:|||||...:| .:|..|.....|::
  Fly   373 KVFRCPMALKKHMYKHDGKELPFPCNICGKRFVINSALKDHLMRHAGIKN-YVCPYCGVGKTTRQ 436

  Fly   300 TYKHHLRTHQTDRPRYPCPDCEKSFVDKYTLKVH-KRVHQPVE 341
            .:..|:.|| |...::.|..||.:..:|.:|..| |.||:.::
  Fly   437 EWNTHILTH-TQEKKFKCHICEHASHNKQSLANHIKIVHEKIK 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	8/21 (38%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..308	CDD:275368	15/48 (31%)
		C2H2 Zn finger	288..303	CDD:275370	3/14 (21%)
		zf-C2H2	315..337	CDD:278523	7/22 (32%)
		C2H2 Zn finger	317..337	CDD:275368	7/20 (35%)
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871
		C2H2 Zn finger	334..353	CDD:275368	5/18 (28%)
		C2H2 Zn finger	368..388	CDD:275368	6/19 (32%)
		COG5048	394..729	CDD:227381	27/87 (31%)
		C2H2 Zn finger	397..417	CDD:275368	8/19 (42%)
		C2H2 Zn finger	425..445	CDD:275368	4/19 (21%)
		C2H2 Zn finger	453..474	CDD:275368	7/20 (35%)
		C2H2 Zn finger	482..502	CDD:275368
		C2H2 Zn finger	510..530	CDD:275368
		C2H2 Zn finger	638..659	CDD:275368
		C2H2 Zn finger	667..687	CDD:275368
		zf-H2C2_2	680..704	CDD:290200
		C2H2 Zn finger	695..715	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449774
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930