DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and CG17612

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_608824.1	Gene:	CG17612 / 33639	FlyBaseID:	FBgn0031597	Length:	618	Species:	Drosophila melanogaster

Alignment Length:	412	Identity:	92/412 - (22%)
Similarity:	142/412 - (34%)	Gaps:	102/412 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QLIEGCIVPGTFKPIKDILKYFEKIINQRLELLPNSAACRDCLEYLFNYDRLVRNLSQVQRQIAD 85
            :.|||..:.|         :||  ||.:.|| .|...:||.|||...|...:..:..|....||.
  Fly   161 EAIEGEDLQG---------EYF--IITECLE-EPAIGSCRVCLEQSDNLTNIFDDAHQYGIPIAT 213

  Fly    86 ALLGCRQVEGKAETKQQAAKRARVQVPAFKIVQATALKEPE---------RQPGEE--DECEEFM 139
            .|   .|..|....|..:... .:.|....:|: .|..:.|         |||.||  |.....:
  Fly   214 IL---SQYTGMPVEKGDSFSE-YICVTCLDVVK-NAFDDLESKENTIQMYRQPKEEIIDIDSIPV 273

  Fly   140 KEEMLDEEFQFSEPDDSMPSSEEEFF--------------TETTEIP------------------ 172
            |.:.:|.|.. .:|....|...:.|.              |.|||.|
  Fly   274 KNKPVDYEVT-GKPPHRCPQCPKIFLLAAKLQAHIRTHNETRTTEPPRLKCPMCPSIYMKRGCLE 337

  Fly   173 ---------------------CHICGEMFSSQEVLERHIKA--DTCQKSEQAT---CNVCGLKVK 211
                                 |..|.::|.....||.||:.  |..|:..:.:   |..|.....
  Fly   338 AHMWIHRASDERESELEPPYRCPHCPKLFLYSSFLEIHIQTHEDVSQRLSRKSSHKCAQCADVFS 402

  Fly   212 DDEVLDLHMNLHEGKTELECRYCDKKFSHKRNVLRHMEVHWDKKKYQCDKCGERFSLSWLMYNHL 276
            |...|..|:.:|.|:...:|..|...|..:.|:..|...|   .:::|.||.:.|.....:..|.
  Fly   403 DVSSLKDHVKIHAGERTFKCPLCLMSFQEESNLKSHDCAH---TRFKCHKCSKFFESQNYLDFHF 464

  Fly   277 MRHDAEENALICEVCHQQFKTKRTYKHHLRTH------QTDRPR--YPCPDCEKSF--VDKYTL- 330
            .:....:....|..|.|.|:.:...|.|:.:.      ::..|.  :|||.|.|.|  .|.|.:
  Fly   465 KKSHTTKGPFKCIKCQQTFQKRNGLKEHISSQVCVQFLRSKSPGQIFPCPKCPKKFSIEDNYQMH 529

  Fly   331 -KVHKRVHQPVEKPESAEAKEA 351
             ..||:|...:|:....:.|::
  Fly   530 HATHKKVKTVIERHNCTQCKKS 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		C2H2 Zn finger	231..251	CDD:275368	5/19 (26%)
		C2H2 Zn finger	259..308	CDD:275368	11/48 (23%)
		C2H2 Zn finger	288..303	CDD:275370	4/14 (29%)
		zf-C2H2	315..337	CDD:278523	10/25 (40%)
		C2H2 Zn finger	317..337	CDD:275368	9/23 (39%)
CG17612	NP_608824.1	zf-AD	187..>246	CDD:285071	16/63 (25%)
		C2H2 Zn finger	290..310	CDD:275368	2/19 (11%)
		C2H2 Zn finger	323..343	CDD:275370	0/19 (0%)
		zf-C2H2_8	356..438	CDD:292531	20/81 (25%)
		C2H2 Zn finger	359..379	CDD:275368	7/19 (37%)
		C2H2 Zn finger	394..414	CDD:275368	5/19 (26%)
		C2H2 Zn finger	422..438	CDD:275368	4/15 (27%)
		C2H2 Zn finger	447..463	CDD:275368	4/15 (27%)
		C2H2 Zn finger	476..505	CDD:275368	6/28 (21%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		C2H2 Zn finger	545..565	CDD:275368	1/7 (14%)
		C2H2 Zn finger	568..584	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449788
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930