DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and ZNF658

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_001304845.1	Gene:	ZNF658 / 26149	HGNCID:	25226	Length:	1059	Species:	Homo sapiens

Alignment Length:	355	Identity:	91/355 - (25%)
Similarity:	143/355 - (40%)	Gaps:	61/355 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RPF-CFVCGKEKSVGVFQLIEGCIVPGTFKPIKDILKYFEKIINQRLELLPNSAACRDCLEYLFN 68
            :|: |..||:                 :|..| .:||     .:||:........|.:| ...|.
Human   628 KPYECNECGR-----------------SFAHI-SVLK-----AHQRIHTGEKPYECNEC-GRSFT 668

  Fly    69 YDRLVRNLSQVQRQIADALLGCRQVEGKAETKQQAAKRARVQVPAFKIVQATALKEPERQPGEED 133
            |:..:|...::.             .|:...:....::......|.||.|.....|   :|.|.:
Human   669 YNSALRAHQRIH-------------TGRKPYECSDCEKTFAHNSALKIHQRIHTGE---KPYECN 717

  Fly   134 ECEE-FMKEEMLDEEFQFSEPDDSMPSSE--EEFFTETT----------EIP--CHICGEMFSSQ 183
            |||: |.....|.........:.....||  :.||.:|.          |.|  |..||:.||.:
Human   718 ECEKTFAHNSALRAHQNIHTGEKLYECSECGKTFFQKTRLSTHRRIHTGEKPYECSKCGKTFSQK 782

  Fly   184 EVLERHIKADTCQKSEQATCNVCGLKVKDDEVLDLHMNLHEGKTELECRYCDKKFSHKRNVLRHM 248
            ..|..|.:..|.:|..:  |||||........|.:|..:|.|:...||..|.|.||.:.::..|.
Human   783 SYLSGHERIHTGEKPYE--CNVCGKTFVYKAALIVHQRIHTGEKPYECNQCGKTFSQRTHLCAHQ 845

  Fly   249 EVHWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENALICEVCHQQFKTKRTYKHHLRTHQTDRP 313
            .:|..:|.|:|::||:.|:.:..:..|...|..|: ...|..|.:.|......:.||||...::|
Human   846 RIHTGEKPYECNECGKTFADNSALRAHHRIHTGEK-PYECNDCGKTFSKTSHLRAHLRTRSGEKP 909

  Fly   314 RYPCPDCEKSFVDKYTLKVHKRVHQPVEKP 343
             |.|.:|.|:|.:|..:..|:|||.. |||
Human   910 -YECSECGKTFSEKSYVSAHQRVHTG-EKP 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..308	CDD:275368	13/48 (27%)
		C2H2 Zn finger	288..303	CDD:275370	3/14 (21%)
		zf-C2H2	315..337	CDD:278523	8/21 (38%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
ZNF658	NP_001304845.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	279..296	CDD:275368
		C2H2 Zn finger	299..319	CDD:275368
		C2H2 Zn finger	328..347	CDD:275368
		C2H2 Zn finger	355..375	CDD:275368
		COG5048	371..789	CDD:227381	41/200 (21%)
		C2H2 Zn finger	389..406	CDD:275368
		C2H2 Zn finger	414..434	CDD:275368
		C2H2 Zn finger	442..462	CDD:275368
		C2H2 Zn finger	520..540	CDD:275368
		zf-H2C2_2	532..557	CDD:290200
		C2H2 Zn finger	548..568	CDD:275368
		zf-H2C2_2	560..585	CDD:290200
		C2H2 Zn finger	576..596	CDD:275368
		zf-H2C2_2	588..613	CDD:290200
		C2H2 Zn finger	604..624	CDD:275368
		zf-H2C2_2	616..641	CDD:290200	5/29 (17%)
		COG5048	628..1044	CDD:227381	91/355 (26%)
		C2H2 Zn finger	632..652	CDD:275368	9/42 (21%)
		zf-H2C2_2	645..669	CDD:290200	7/29 (24%)
		C2H2 Zn finger	660..680	CDD:275368	5/20 (25%)
		zf-H2C2_2	672..697	CDD:290200	2/37 (5%)
		C2H2 Zn finger	688..708	CDD:275368	4/19 (21%)
		zf-H2C2_2	700..725	CDD:290200	11/27 (41%)
		C2H2 Zn finger	716..736	CDD:275368	5/19 (26%)
		C2H2 Zn finger	744..764	CDD:275368	5/19 (26%)
		zf-H2C2_2	757..781	CDD:290200	6/23 (26%)
		C2H2 Zn finger	772..792	CDD:275368	7/19 (37%)
		zf-H2C2_2	784..809	CDD:290200	9/26 (35%)
		C2H2 Zn finger	800..820	CDD:275368	7/19 (37%)
		zf-H2C2_2	812..837	CDD:290200	9/24 (38%)
		C2H2 Zn finger	828..848	CDD:275368	6/19 (32%)
		zf-H2C2_2	844..864	CDD:290200	7/19 (37%)
		C2H2 Zn finger	856..876	CDD:275368	5/19 (26%)
		zf-H2C2_2	868..892	CDD:290200	5/24 (21%)
		C2H2 Zn finger	884..903	CDD:275368	5/18 (28%)
		C2H2 Zn finger	912..932	CDD:275368	7/19 (37%)
		C2H2 Zn finger	940..960	CDD:275368
		zf-H2C2_2	953..977	CDD:290200
		C2H2 Zn finger	968..988	CDD:275368
		zf-H2C2_2	980..1005	CDD:290200
		C2H2 Zn finger	996..1016	CDD:275368
		zf-H2C2_2	1009..1033	CDD:290200
		C2H2 Zn finger	1024..1045	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000