DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and Zfp26

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	XP_011240753.1	Gene:	Zfp26 / 22688	MGIID:	99173	Length:	965	Species:	Mus musculus

Alignment Length:	401	Identity:	96/401 - (23%)
Similarity:	154/401 - (38%)	Gaps:	115/401 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GCIVPGTFKPIKDILKYFEKIINQRLELLPNSAACRDCLEYLFNYDRLVRNLSQVQRQIADALLG 89
            |.::| |.|      ||:|               |:.| |..|.:. :..|: .:|....:....
Mouse   340 GHVIP-TEK------KYYE---------------CKKC-EKFFTHP-VYLNI-HMQSHTVEKPYD 379

  Fly    90 CRQVEGKAETKQQAAKRARVQVPAFKIVQATALKEPERQPGEE-DEC----------EEFMKEEM 143
            |::. |||.|::.:.           ||.   |::..|:...| .||          .|.|:...
Mouse   380 CKEC-GKAFTERSSL-----------IVH---LRQHTREKSYECKECGKTFIQPSRLTEHMRSHT 429

  Fly   144 LDEEFQFSEPDDSMPSS------------EEEF-------------------FTETTEIP--CHI 175
            .::.:|..:..::..||            |:.|                   .|.|.|.|  |.:
Mouse   430 GEKPYQCDQCGNAFASSSYLTTHLRTHTGEKPFECNICGKAFTRSSYLLGHIRTHTGEKPYECKV 494

  Fly   176 CGEMFSSQEVLERHIKADT------CQKSEQA--------------------TCNVCGLKVKDDE 214
            ||:.||.:..|..|::..|      |.:.|:|                    .|.||....::..
Mouse   495 CGKAFSGRSWLTIHLRKHTGERPYPCTECEKAFTSFAQLTEHIKTHTGEKPFRCKVCARTFRNSS 559

  Fly   215 VLDLHMNLHEGKTELECRYCDKKFSHKRNVLRHMEVHWDKKKYQCDKCGERFSLSWLMYNHLMRH 279
            .|..|..:|.|....:|.||.|.|:.:..:.:|:.:|..:|.|:|.:||:.||.|..:..|:..|
Mouse   560 CLKTHFRIHTGIKPYKCNYCGKAFTARSGLTKHVLIHNGEKPYECKECGKAFSTSSGLVEHIRIH 624

  Fly   280 DAEENALICEVCHQQFKTKRTYKHHLRTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVHQPVEKPE 344
            ..|: ...|..|.:......:...|||||..::| :.|..|:|:|.....|::|.|.|.. |||
Mouse   625 TGEK-PFECYQCGKALAHSSSLVGHLRTHTGEKP-FECNQCDKTFTRSSYLRIHMRTHTG-EKP- 685

  Fly   345 SAEAKEATVTF 355
             .|.||...||
Mouse   686 -YECKECGKTF 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..308	CDD:275368	14/48 (29%)
		C2H2 Zn finger	288..303	CDD:275370	2/14 (14%)
		zf-C2H2	315..337	CDD:278523	7/21 (33%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
Zfp26	XP_011240753.1	KRAB	113..171	CDD:214630
		C2H2 Zn finger	297..317	CDD:275368
		COG5048	325..760	CDD:227381	96/401 (24%)
		C2H2 Zn finger	352..372	CDD:275368	6/22 (27%)
		C2H2 Zn finger	380..400	CDD:275368	8/34 (24%)
		C2H2 Zn finger	408..428	CDD:275368	4/19 (21%)
		C2H2 Zn finger	436..456	CDD:275368	2/19 (11%)
		C2H2 Zn finger	464..484	CDD:275368	0/19 (0%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	3/19 (16%)
		C2H2 Zn finger	548..568	CDD:275368	5/19 (26%)
		C2H2 Zn finger	576..596	CDD:275368	6/19 (32%)
		COG5048	600..956	CDD:227381	35/101 (35%)
		C2H2 Zn finger	604..624	CDD:275368	7/19 (37%)
		C2H2 Zn finger	632..652	CDD:275368	5/19 (26%)
		C2H2 Zn finger	660..680	CDD:275368	7/19 (37%)
		C2H2 Zn finger	688..708	CDD:275368	4/8 (50%)
		C2H2 Zn finger	716..736	CDD:275368
		C2H2 Zn finger	744..764	CDD:275368
		C2H2 Zn finger	772..792	CDD:275368
		C2H2 Zn finger	800..820	CDD:275368
		C2H2 Zn finger	828..848	CDD:275368
		C2H2 Zn finger	856..876	CDD:275368
		C2H2 Zn finger	884..904	CDD:275368
		C2H2 Zn finger	912..932	CDD:275368
		C2H2 Zn finger	940..956	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000