DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and ZNF449

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_689908.3	Gene:	ZNF449 / 203523	HGNCID:	21039	Length:	518	Species:	Homo sapiens

Alignment Length:	337	Identity:	79/337 - (23%)
Similarity:	133/337 - (39%)	Gaps:	67/337 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NSAACRDCLEYL----------FNY------DRLVRNL--SQVQRQIADALLGCR-QVEGKAETK 100
            |..|..:|..:|          .|:      :..|:.|  |:..:|:.|:.:|.. .:|.:.:|.
Human   173 NYGATGECQNFLDPGYPLPKLDMNFSLENREEPWVKELQDSKEMKQLLDSKIGFEIGIENEEDTS 237

  Fly   101 QQAAKRARVQVPAFKIVQATALKEPERQPGEEDECEEFMKEEMLDEEFQFSEP------------ 153
            :|  |:.....|....::..||:.|            .::::.:..|.|:..|
Human   238 KQ--KKMETMYPFIVTLEGNALQGP------------ILQKDYVQLENQWETPPEDLQTDLAKLV 288

  Fly   154 DDSMPSSEEEFFTETTEIP-----------------CHICGEMFSSQEVLERHIKADTCQKSEQA 201
            |...|:..|.......|.|                 |..||:.|:.:..|..|.:..:.:  |..
Human   289 DQQNPTLGETPENSNLEEPLNPKPHKKKSPGEKPHRCPQCGKCFARKSQLTGHQRIHSGE--EPH 351

  Fly   202 TCNVCGLKVKDDEVLDLHMNLHEGKTELECRYCDKKFSHKRNVLRHMEVHWDKKKYQCDKCGERF 266
            .|..||.:......|..|..||.|:...||..|.|:|:.:.:::.|...|.:::.|:|.:||:.|
Human   352 KCPECGKRFLRSSDLYRHQRLHTGERPYECTVCKKRFTRRSHLIGHQRTHSEEETYKCLECGKSF 416

  Fly   267 SLSWLMYNHLMRHDAEENALICEVCHQQFKTKRTYKHHLRTHQTDRPRYPCPDCEKSFVDKYTLK 331
            .....:..||..|..|:... |..|.:.|........|.|||..:|| :.|..|.|||..:.:|.
Human   417 CHGSSLKRHLKTHTGEKPHR-CHNCGKSFSRLTALTLHQRTHTEERP-FKCNYCGKSFRQRPSLV 479

  Fly   332 VHKRVHQPVEKP 343
            :|.|:|.. |||
Human   480 IHLRIHTG-EKP 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		C2H2 Zn finger	231..251	CDD:275368	5/19 (26%)
		C2H2 Zn finger	259..308	CDD:275368	13/48 (27%)
		C2H2 Zn finger	288..303	CDD:275370	3/14 (21%)
		zf-C2H2	315..337	CDD:278523	8/21 (38%)
		C2H2 Zn finger	317..337	CDD:275368	8/19 (42%)
ZNF449	NP_689908.3	SCAN	27..134	CDD:322011
		SFP1	<235..402	CDD:227516	36/182 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..325		4/32 (13%)
		COG5048	<321..483	CDD:227381	47/165 (28%)
		C2H2 Zn finger	325..345	CDD:275368	6/19 (32%)
		C2H2 Zn finger	353..373	CDD:275368	5/19 (26%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		C2H2 Zn finger	409..429	CDD:275368	6/19 (32%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		C2H2 Zn finger	465..485	CDD:275368	8/19 (42%)
		zf-H2C2_2	477..502	CDD:316026	7/15 (47%)
		C2H2 Zn finger	493..513	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000