DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sry-beta and ZFP28

DIOPT Version :9

Sequence 1:NP_001303451.1 Gene:Sry-beta / 43570 FlyBaseID:FBgn0003511 Length:356 Species:Drosophila melanogaster
Sequence 2:NP_065879.1 Gene:ZFP28 / 140612 HGNCID:17801 Length:868 Species:Homo sapiens


Alignment Length:256 Identity:69/256 - (26%)
Similarity:105/256 - (41%) Gaps:48/256 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 QPGEEDECEE-FMKEEMLDEEFQFSEPDDSMPSSEEEFFTETTEIPCHICGEMFSSQEVLERHIK 191
            :|.|.|.|.: |.....|.:.       ..:.|.|:.|       .|..||:.|.....|..|::
Human   559 KPYECDVCRKAFSHHASLTQH-------QRVHSGEKPF-------KCKECGKAFRQNIHLASHLR 609

  Fly   192 ADTCQKSEQATCNVCGLKVKDDEVLDLHMNLHEGKTELECRYCDKKFSHKRNVLRHMEVHWDKKK 256
            ..|.:|..:  |..||........|..|..:|.|:...||:.|.|.|:.|.::.:|.:.|..:|.
Human   610 IHTGEKPFE--CAECGKSFSISSQLATHQRIHTGEKPYECKVCSKAFTQKAHLAQHQKTHTGEKP 672

  Fly   257 YQCDKCGERFSLSWLMYNHLMRHDAE---------------------------ENALICEVCHQQ 294
            |:|.:||:.||.:..:..|...|..|                           :....|..|.:.
Human   673 YECKECGKAFSQTTHLIQHQRVHTGEKPYKCMECGKAFGDNSSCTQHQRLHTGQRPYECIECGKA 737

  Fly   295 FKTKRTYKHHLRTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVHQPVEKPESAEAKEATVTF 355
            ||||.:...|.|:|..::| |.|..|.|:|..:.:|.||:|:|.. :||  .|.||...||
Human   738 FKTKSSLICHRRSHTGEKP-YECSVCGKAFSHRQSLSVHQRIHSG-KKP--YECKECRKTF 794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sry-betaNP_001303451.1 C2H2 Zn finger 203..223 CDD:275368 5/19 (26%)
C2H2 Zn finger 231..251 CDD:275368 6/19 (32%)
C2H2 Zn finger 259..308 CDD:275368 16/75 (21%)
C2H2 Zn finger 288..303 CDD:275370 6/14 (43%)
zf-C2H2 315..337 CDD:278523 9/21 (43%)
C2H2 Zn finger 317..337 CDD:275368 8/19 (42%)
ZFP28NP_065879.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..82
KRAB 103..163 CDD:214630
KRAB 103..142 CDD:279668
KRAB 232..288 CDD:214630
KRAB 232..266 CDD:279668
COG5048 417..806 CDD:227381 69/256 (27%)
zf-C2H2 420..442 CDD:278523
C2H2 Zn finger 422..442 CDD:275368
zf-H2C2_2 434..458 CDD:290200
C2H2 Zn finger 450..470 CDD:275368
zf-H2C2_2 462..487 CDD:290200
C2H2 Zn finger 478..496 CDD:275368
C2H2 Zn finger 507..527 CDD:275368
zf-H2C2_2 520..544 CDD:290200
C2H2 Zn finger 535..555 CDD:275368
zf-H2C2_2 547..572 CDD:290200 5/12 (42%)
C2H2 Zn finger 563..583 CDD:275368 4/26 (15%)
zf-H2C2_2 575..600 CDD:290200 8/38 (21%)
C2H2 Zn finger 591..611 CDD:275368 6/19 (32%)
zf-H2C2_2 603..627 CDD:290200 7/25 (28%)
C2H2 Zn finger 619..639 CDD:275368 5/19 (26%)
zf-H2C2_2 632..656 CDD:290200 9/23 (39%)
C2H2 Zn finger 647..667 CDD:275368 6/19 (32%)
zf-H2C2_2 659..684 CDD:290200 8/24 (33%)
C2H2 Zn finger 675..695 CDD:275368 6/19 (32%)
zf-H2C2_2 687..710 CDD:290200 3/22 (14%)
C2H2 Zn finger 703..723 CDD:275368 0/19 (0%)
zf-H2C2_2 718..740 CDD:290200 3/21 (14%)
C2H2 Zn finger 731..751 CDD:275368 8/19 (42%)
zf-H2C2_2 743..768 CDD:290200 9/25 (36%)
C2H2 Zn finger 759..779 CDD:275368 8/19 (42%)
zf-H2C2_2 771..796 CDD:290200 12/27 (44%)
C2H2 Zn finger 787..807 CDD:275368 4/8 (50%)
C2H2 Zn finger 815..835 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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