DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and ZNF358

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_060553.4	Gene:	ZNF358 / 140467	HGNCID:	16838	Length:	568	Species:	Homo sapiens

Alignment Length:	171	Identity:	54/171 - (31%)
Similarity:	76/171 - (44%)	Gaps:	5/171 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 CHICGEMFSSQEVLERHIKADTCQKSEQATCNVCGLKVKDDEVLDLHMNLHEGKTELECRYCDKK 237
            |..||:.|..:..|.:|..:.:.:|...  |.|||.......:|..|:..|.|....:|..|.|.
Human   209 CAACGKAFGWRSTLLKHRSSHSGEKPHH--CPVCGKAFGHGSLLAQHLRTHGGPRPHKCPVCAKG 271

  Fly   238 FSHKRNVLRHMEVHWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENALICEVCHQQFKTKRTYK 302
            |.....:|:|:..|..::.|.|.:||:.|..|..:..|...|.| |....|..|.:.|......:
Human   272 FGQGSALLKHLRTHTGERPYPCPQCGKAFGQSSALLQHQRTHTA-ERPYRCPHCGKAFGQSSNLQ 335

  Fly   303 HHLRTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVHQPVEKP 343
            ||||.|..:|| |.||.|.|:|.....|..|..||.. |:|
Human   336 HHLRIHTGERP-YACPHCSKAFGQSSALLQHLHVHSG-ERP 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	6/19 (32%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..308	CDD:275368	16/48 (33%)
		C2H2 Zn finger	288..303	CDD:275370	3/14 (21%)
		zf-C2H2	315..337	CDD:278523	8/21 (38%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
ZNF358	NP_060553.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..117
		COG5048	<35..339	CDD:227381	37/132 (28%)
		lambda-1	108..>174	CDD:212564
		zf-C2H2	151..173	CDD:278523
		C2H2 Zn finger	153..173	CDD:275368
		zf-H2C2_2	166..190	CDD:290200
		C2H2 Zn finger	181..201	CDD:275368
		zf-H2C2_2	194..216	CDD:290200	3/6 (50%)
		C2H2 Zn finger	209..229	CDD:275368	6/19 (32%)
		zf-H2C2_2	222..244	CDD:290200	7/23 (30%)
		C2H2 Zn finger	237..257	CDD:275368	6/19 (32%)
		zf-H2C2_2	250..272	CDD:290200	7/21 (33%)
		C2H2 Zn finger	265..285	CDD:275368	6/19 (32%)
		zf-H2C2_2	277..300	CDD:290200	7/22 (32%)
		zf-C2H2_8	292..370	CDD:292531	28/79 (35%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
		zf-H2C2_2	305..328	CDD:290200	6/23 (26%)
		C2H2 Zn finger	321..341	CDD:275368	7/19 (37%)
		zf-H2C2_2	333..356	CDD:290200	12/23 (52%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		zf-H2C2_2	361..384	CDD:290200	6/15 (40%)
		zf-C2H2	375..397	CDD:278523	54/171 (32%)
		C2H2 Zn finger	377..397	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910