DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and ZNF268

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_001159353.1	Gene:	ZNF268 / 10795	HGNCID:	13061	Length:	947	Species:	Homo sapiens

Alignment Length:	389	Identity:	96/389 - (24%)
Similarity:	146/389 - (37%)	Gaps:	73/389 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RPF-CFVCGKEKSVGVFQLIEGCIVPG-TFKPIKDILKYF----EKIINQRLELLPNSAACRDCL 63
            :|: |..|||:.|...:.::...|..| ......:..|.|    :.:|:||:....|...|.:|.
Human   302 KPYGCNECGKDFSSKSYLIVHQRIHTGEKLHECSECRKTFSFHSQLVIHQRIHTGENPYECCECG 366

  Fly    64 EYLFNYDRLVRNLSQVQRQIADALLGCRQVEGKA-ETKQQAAKRARVQVPAFKIVQATALKEPER 127
            :.....|:||.:......|.......|    ||| ..|.|.....|:..              ..
Human   367 KVFSRKDQLVSHQKTHSGQKPYVCNEC----GKAFGLKSQLIIHERIHT--------------GE 413

  Fly   128 QPGEEDECEEFM--KEEMLDEEFQFSEPDDSMPSSEEEFFTETTEI------------------- 171
            :|.|.:||::..  |..::..:...:.....:.|...:.||..:::
Human   414 KPYECNECQKAFNTKSNLMVHQRTHTGEKPYVCSDCGKAFTFKSQLIVHQGIHTGVKPYGCIQCG 478

  Fly   172 ----------------------PCHICGEMFSSQEVLERHIKADTCQKSEQATCNVCGLKVKDDE 214
                                  .|:.||:.|.|:..|..|.:..|.:|..:  ||.||.......
Human   479 KGFSLKSQLIVHQRSHTGMKPYVCNECGKAFRSKSYLIIHTRTHTGEKLHE--CNNCGKAFSFKS 541

  Fly   215 VLDLHMNLHEGKTELECRYCDKKFSHKRNVLRHMEVHWDKKKYQCDKCGERFSLSWLMYNHLMRH 279
            .|.:|..:|.|:...||..|.|.||.|..::.|...|..:|.|:|..||:.|.|...:..|...|
Human   542 QLIIHQRIHTGENPYECHECGKAFSRKYQLISHQRTHAGEKPYECTDCGKAFGLKSQLIIHQRTH 606

  Fly   280 DAEENALICEVCHQQFKTKRTYKHHLRTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVHQPVEKP 343
            ..|: ...|..|.:.|.||.....|.|||..::| |.|.:|.|:|..|..|.|||.||..| ||
Human   607 TGEK-PFECSECQKAFNTKSNLIVHQRTHTGEKP-YSCNECGKAFTFKSQLIVHKGVHTGV-KP 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	6/19 (32%)
		C2H2 Zn finger	231..251	CDD:275368	7/19 (37%)
		C2H2 Zn finger	259..308	CDD:275368	15/48 (31%)
		C2H2 Zn finger	288..303	CDD:275370	5/14 (36%)
		zf-C2H2	315..337	CDD:278523	10/21 (48%)
		C2H2 Zn finger	317..337	CDD:275368	9/19 (47%)
ZNF268	NP_001159353.1	KRAB	81..141	CDD:214630
		KRAB	81..120	CDD:279668
		C2H2 Zn finger	278..298	CDD:275368
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	5/19 (26%)
		zf-H2C2_2	347..371	CDD:290200	6/23 (26%)
		C2H2 Zn finger	362..382	CDD:275368	5/19 (26%)
		zf-H2C2_2	375..397	CDD:290200	6/25 (24%)
		C2H2 Zn finger	390..410	CDD:275368	7/23 (30%)
		zf-H2C2_2	403..427	CDD:290200	5/37 (14%)
		C2H2 Zn finger	418..438	CDD:275368	3/19 (16%)
		zf-H2C2_2	430..454	CDD:290200	1/23 (4%)
		C2H2 Zn finger	446..466	CDD:275368	3/19 (16%)
		C2H2 Zn finger	474..494	CDD:275368	0/19 (0%)
		COG5048	497..910	CDD:227381	61/176 (35%)
		C2H2 Zn finger	502..522	CDD:275368	7/19 (37%)
		C2H2 Zn finger	530..550	CDD:275368	6/19 (32%)
		zf-H2C2_2	543..567	CDD:290200	9/23 (39%)
		zf-C2H2	556..578	CDD:278523	8/21 (38%)
		C2H2 Zn finger	558..578	CDD:275368	7/19 (37%)
		C2H2 Zn finger	586..606	CDD:275368	6/19 (32%)
		zf-H2C2_2	599..623	CDD:290200	6/24 (25%)
		C2H2 Zn finger	614..634	CDD:275368	7/19 (37%)
		zf-H2C2_2	626..650	CDD:290200	9/24 (38%)
		C2H2 Zn finger	642..662	CDD:275368	9/19 (47%)
		C2H2 Zn finger	670..690	CDD:275368
		C2H2 Zn finger	698..718	CDD:275368
		zf-H2C2_2	710..734	CDD:290200
		C2H2 Zn finger	726..746	CDD:275368
		zf-H2C2_2	739..763	CDD:290200
		C2H2 Zn finger	754..774	CDD:275368
		C2H2 Zn finger	782..802	CDD:275368
		zf-H2C2_2	794..817	CDD:290200
		C2H2 Zn finger	810..830	CDD:275368
		C2H2 Zn finger	838..858	CDD:275368
		zf-H2C2_2	851..875	CDD:290200
		C2H2 Zn finger	866..886	CDD:275368
		C2H2 Zn finger	894..914	CDD:275368
		zf-H2C2_2	907..929	CDD:290200
		C2H2 Zn finger	922..942	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000