DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sry-beta and znf1069

DIOPT Version :9

Sequence 1:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_001103337.1	Gene:	znf1069 / 100126141	ZFINID:	ZDB-GENE-071004-89	Length:	363	Species:	Danio rerio

Alignment Length:	246	Identity:	74/246 - (30%)
Similarity:	112/246 - (45%)	Gaps:	25/246 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 KIVQATALKEPERQPGEEDEC----EEFMKEEMLDEEFQFSEPDDSMPSSEEEFFTETT------ 169
            ||.:...:|:.:.|  |:.:.    ||..:..:::|:.||.:..| :.:.|:...|:.|
Zfish    12 KIEETFTVKQEDLQ--EQTDLMVLKEETHQLNVMEEKQQFEKHQD-ITTDEKPTLTKKTSSRGRP 73

  Fly   170 -------EIPCHICGEMFSSQEVLERHIKADTCQKSEQATCNVCGLKVKDDEVLDLHMNLHEGKT 227
                   ...|..|.:.||.:..|:.||:..|..|  ..||..||......:....||.:|.|:.
Zfish    74 RKSKSGCNFSCTRCRKSFSQKPKLDVHIRVHTGGK--PYTCEQCGKSFSQKQSFKTHMRIHTGER 136

  Fly   228 ELECRYCDKKFSHKRNVLRHMEVHWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENALICEVCH 292
            ...|:.|.|.|:|..|...|..:|..::||.|.:||:.|..:..:..|:..|..|| ...|..|.
Zfish   137 PYTCQQCGKSFNHAGNFAAHKRIHTGERKYTCQQCGKSFYNTGNLAVHMRIHTGEE-PYSCSQCG 200

  Fly   293 QQFKTKRTYKHHLRTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVHQPVEKP 343
            ..||...|.|.|:|||..:| |:.|..|.|||..|..|.:|.|:|.. |||
Zfish   201 NSFKQNVTLKIHMRTHTGER-RFTCTQCGKSFSQKQDLGIHMRIHTG-EKP 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		C2H2 Zn finger	231..251	CDD:275368	7/19 (37%)
		C2H2 Zn finger	259..308	CDD:275368	16/48 (33%)
		C2H2 Zn finger	288..303	CDD:275370	5/14 (36%)
		zf-C2H2	315..337	CDD:278523	9/21 (43%)
		C2H2 Zn finger	317..337	CDD:275368	9/19 (47%)
znf1069	NP_001103337.1	C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		COG5048	<88..329	CDD:227381	58/167 (35%)
		zf-H2C2_2	97..121	CDD:290200	9/25 (36%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		zf-H2C2_2	124..149	CDD:290200	8/24 (33%)
		C2H2 Zn finger	140..160	CDD:275368	7/19 (37%)
		C2H2 Zn finger	168..188	CDD:275368	5/19 (26%)
		zf-H2C2_2	180..205	CDD:290200	7/25 (28%)
		C2H2 Zn finger	196..216	CDD:275368	8/19 (42%)
		zf-H2C2_2	209..233	CDD:290200	12/24 (50%)
		C2H2 Zn finger	224..244	CDD:275368	9/19 (47%)
		zf-H2C2_2	236..259	CDD:290200	7/15 (47%)
		C2H2 Zn finger	252..272	CDD:275368
		zf-H2C2_2	265..289	CDD:290200
		C2H2 Zn finger	280..300	CDD:275368
		C2H2 Zn finger	308..328	CDD:275368
		C2H2 Zn finger	335..355	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910