Protein Alignment ZIPIC and SNAI1

DIOPT Version :10

• Sequence 1: NP_651765.1
• Gene: ZIPIC / 43566
• FlyBaseID: FBgn0039740
• Length: 457
• Species: Drosophila melanogaster
• Sequence 2: NP_005976.2
• Gene: SNAI1 / 6615
• HGNCID: 11128
• Length: 264
• Species: Homo sapiens
• Alignment Length: 211
• Identity: 54/211 - (25%)
• Similarity: 82/211 - (38%)
• Gaps: 45/211 - (21%)

  Fly   247 NESSGEYTVNIQCPS-CPEKFSSRRAYNVHTKR-EHFPGYVCDQCGKTLQSYSGFIGHLQNHEPV 309
            :|.||:.:.....|| .|..|||....::..:. ..|||  ..|..|.|...|    ..::.:..
Human    93 DEDSGKGSQPPSPPSPAPSSFSSTSVSSLEAEAYAAFPG--LGQVPKQLAQLS----EAKDLQAR 151

  Fly   310 KQFACPVCPERFSRKFRLKHHMAWHSGETPYQCDVCSKRFVHKVALYKHKMIHDSETKRLECQVC 374
            |.|.|..|.:.:.....||.|:..|:  .|..|..|.|.|.....
Human   152 KAFNCKYCNKEYLSLGALKMHIRSHT--LPCVCGTCGKAFSRPWL-------------------- 194

  Fly   375 GFKTRTKAHLERHMRSHTGDKPFACPVCNKRFSQMYNMKAHLREHESPGTNRHRRFHCSKCTHTF 439
                     |:.|:|:|||:|||:||.|::.|:...|::|||:.|...     :::.|..|..||
Human   195 ---------LQGHVRTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDV-----KKYQCQACARTF 245

  Fly   440 INEQNYDAHVQRDDCT 455
            ........| |...|:
Human   246 SRMSLLHKH-QESGCS 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZIPIC	NP_651765.1	C2H2 Zn finger	286..306	CDD:275368	4/19 (21%)
		C2H2 Zn finger	314..334	CDD:275368	5/19 (26%)
		SFP1	<336..419	CDD:227516	22/82 (27%)
		C2H2 Zn finger	342..391	CDD:275368	7/48 (15%)
		zf-H2C2_2	383..408	CDD:463886	13/24 (54%)
		C2H2 Zn finger	399..419	CDD:275368	8/19 (42%)
		C2H2 Zn finger	432..449	CDD:275368	4/16 (25%)
SNAI1	NP_005976.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		SNAG domain. /evidence=ECO:0000305|PubMed:20389281, ECO:0000305|PubMed:21300290	1..20
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:23721412	2..7
		LATS2 binding	10..40
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	86..115		7/21 (33%)
		Destruction motif	95..100		2/4 (50%)
		Required for FBXL14-triggered degradation	120..151		7/36 (19%)
		Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP1. /evidence=ECO:0000269|PubMed:21577210, ECO:0000269|PubMed:22128911	151..264		38/147 (26%)
		C2H2 Zn finger	156..176	CDD:275368	5/19 (26%)
		C2H2 Zn finger	182..202	CDD:275368	7/48 (15%)
		zf-H2C2_2	195..218	CDD:463886	12/22 (55%)
		zf-C2H2	208..230	CDD:395048	9/21 (43%)
		C2H2 Zn finger	210..230	CDD:275368	8/19 (42%)
		C2H2 Zn finger	238..255	CDD:275368	5/17 (29%)