DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZIPIC and CTCFL

DIOPT Version :9

Sequence 1:NP_651765.1 Gene:ZIPIC / 43566 FlyBaseID:FBgn0039740 Length:457 Species:Drosophila melanogaster
Sequence 2:NP_001255972.1 Gene:CTCFL / 140690 HGNCID:16234 Length:700 Species:Homo sapiens


Alignment Length:463 Identity:106/463 - (22%)
Similarity:182/463 - (39%) Gaps:102/463 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 ISELVLQCTRGTNYVLTEESSTICKKCCEKLARYHKSIQIARKLRGEILELIHSPYMSKDHKQTS 92
            |.||.|...:|   :..||...:|::                                |||:..|
Human    16 IKELELMPEKG---LKEEEKDGVCRE--------------------------------KDHRSPS 45

  Fly    93 YKEDDLDRETTISKFDGNIEEAQQQ-----DEEEQELESVGTTVTLVGPAGIVEE-----VAEEE 147
                :|:.|.|...|..::.|.:.:     .||.::......||.....|..:::     :.::|
Human    46 ----ELEAERTSGAFQDSVLEEEVELVLAPSEESEKYILTLQTVHFTSEAVELQDMSLLSIQQQE 106

  Fly   148 HTFIIKQSE-------EEDEFHSVD--LELDIDNEIIINEE----EAHEVEE---VAHEIEEVA- 195
            ...::.|..       ||....|:.  :.:.|..|:...:|    :.|.:||   ||.|..::| 
Human   107 GVQVVVQQPGPGLLWLEEGPRQSLQQCVAISIQQELYSPQEMEVLQFHALEENVMVASEDSKLAV 171

  Fly   196 ------------HEIEEEDLLPHDKQEAQEEDFFKEDTMSDFDEHLDGAIEYIISDGEDQEQDNE 248
                        .|.|:..||    .|..:|..|..:|||. ||..|..:..:.:...::::|..
Human   172 SLAETTGLIKLEEEQEKNQLL----AERTKEQLFFVETMSG-DERSDEIVLTVSNSNVEEQEDQP 231

  Fly   249 SSGEYTVNIQCPSCPEKFSSRRAYNVHTKREHFPGYVCDQCGKTLQSYSGFIGHLQNHEPVKQFA 313
            ::|:        :..||..|.:  |....:.....:.||.|..|....|.|..|::.|...|...
Human   232 TAGQ--------ADAEKAKSTK--NQRKTKGAKGTFHCDVCMFTSSRMSSFNRHMKTHTSEKPHL 286

  Fly   314 CPVCPERFSRKFRLKHHMAWHSGETPYQCDVCSKRFVHKVALYKHKMIHDSETKRLECQVCGFKT 378
            |.:|.:.|.....|::|:..|:|..||:|:.|:..||....|.:|:....:..|..:|.:|.:.:
Human   287 CHLCLKTFRTVTLLRNHVNTHTGTRPYKCNDCNMAFVTSGELVRHRRYKHTHEKPFKCSMCKYAS 351

  Fly   379 RTKAHLERHMRSHTGDKPFACPVCNKRFSQMYNMKAHLREH--ESPGTNRHRRFHCSKCTHTFIN 441
            ...:.|:||:|||||::||.|..|:......|.:|.|:|.|  |.|       :.|..|...|..
Human   352 VEASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHSGEKP-------YECHICHTRFTQ 409

  Fly   442 EQNYDAHV 449
            ......|:
Human   410 SGTMKIHI 417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZIPICNP_651765.1 C2H2 Zn finger 286..306 CDD:275368 7/19 (37%)
C2H2 Zn finger 314..334 CDD:275368 5/19 (26%)
zf-H2C2_2 327..351 CDD:290200 9/23 (39%)
C2H2 Zn finger 342..391 CDD:275368 13/48 (27%)
zf-H2C2_2 383..408 CDD:290200 12/24 (50%)
C2H2 Zn finger 399..419 CDD:275368 6/19 (32%)
C2H2 Zn finger 432..449 CDD:275368 3/16 (19%)
CTCFLNP_001255972.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..55 11/69 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 221..250 6/38 (16%)
COG5048 <259..403 CDD:227381 47/150 (31%)
C2H2 Zn finger 259..279 CDD:275368 7/19 (37%)
zf-H2C2_2 271..296 CDD:290200 7/24 (29%)
C2H2 Zn finger 287..307 CDD:275368 5/19 (26%)
zf-H2C2_2 300..324 CDD:290200 9/23 (39%)
C2H2 Zn finger 315..333 CDD:275368 6/17 (35%)
C2H2 Zn finger 344..364 CDD:275368 6/19 (32%)
zf-H2C2_2 357..378 CDD:290200 12/20 (60%)
C2H2 Zn finger 372..392 CDD:275368 6/19 (32%)
zf-H2C2_2 385..409 CDD:290200 9/30 (30%)
C2H2 Zn finger 400..417 CDD:275368 3/16 (19%)
C2H2 Zn finger 430..448 CDD:275368
C2H2 Zn finger 460..480 CDD:275368
C2H2 Zn finger 488..508 CDD:275368
zf-H2C2_2 500..525 CDD:290200
C2H2 Zn finger 516..534 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 569..630
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR24406
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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