Protein Alignment ZIPIC and CTCFL

DIOPT Version :10

• Sequence 1: NP_651765.1
• Gene: ZIPIC / 43566
• FlyBaseID: FBgn0039740
• Length: 457
• Species: Drosophila melanogaster
• Sequence 2: NP_001255972.1
• Gene: CTCFL / 140690
• HGNCID: 16234
• Length: 700
• Species: Homo sapiens
• Alignment Length: 463
• Identity: 106/463 - (22%)
• Similarity: 182/463 - (39%)
• Gaps: 102/463 - (22%)

  Fly    28 ISELVLQCTRGTNYVLTEESSTICKKCCEKLARYHKSIQIARKLRGEILELIHSPYMSKDHKQTS 92
            |.||.|...:|   :..||...:|::                                |||:..|
Human    16 IKELELMPEKG---LKEEEKDGVCRE--------------------------------KDHRSPS 45

  Fly    93 YKEDDLDRETTISKFDGNIEEAQQQ-----DEEEQELESVGTTVTLVGPAGIVEE-----VAEEE 147
                :|:.|.|...|..::.|.:.:     .||.::......||.....|..:::     :.::|
Human    46 ----ELEAERTSGAFQDSVLEEEVELVLAPSEESEKYILTLQTVHFTSEAVELQDMSLLSIQQQE 106

  Fly   148 HTFIIKQSE-------EEDEFHSVD--LELDIDNEIIINEE----EAHEVEE---VAHEIEEVA- 195
            ...::.|..       ||....|:.  :.:.|..|:...:|    :.|.:||   ||.|..::|
Human   107 GVQVVVQQPGPGLLWLEEGPRQSLQQCVAISIQQELYSPQEMEVLQFHALEENVMVASEDSKLAV 171

  Fly   196 ------------HEIEEEDLLPHDKQEAQEEDFFKEDTMSDFDEHLDGAIEYIISDGEDQEQDNE 248
                        .|.|:..||    .|..:|..|..:|||. ||..|..:..:.:...::::|..
Human   172 SLAETTGLIKLEEEQEKNQLL----AERTKEQLFFVETMSG-DERSDEIVLTVSNSNVEEQEDQP 231

  Fly   249 SSGEYTVNIQCPSCPEKFSSRRAYNVHTKREHFPGYVCDQCGKTLQSYSGFIGHLQNHEPVKQFA 313
            ::|:        :..||..|.:  |....:.....:.||.|..|....|.|..|::.|...|...
Human   232 TAGQ--------ADAEKAKSTK--NQRKTKGAKGTFHCDVCMFTSSRMSSFNRHMKTHTSEKPHL 286

  Fly   314 CPVCPERFSRKFRLKHHMAWHSGETPYQCDVCSKRFVHKVALYKHKMIHDSETKRLECQVCGFKT 378
            |.:|.:.|.....|::|:..|:|..||:|:.|:..||....|.:|:....:..|..:|.:|.:.:
Human   287 CHLCLKTFRTVTLLRNHVNTHTGTRPYKCNDCNMAFVTSGELVRHRRYKHTHEKPFKCSMCKYAS 351

  Fly   379 RTKAHLERHMRSHTGDKPFACPVCNKRFSQMYNMKAHLREH--ESPGTNRHRRFHCSKCTHTFIN 441
            ...:.|:||:|||||::||.|..|:......|.:|.|:|.|  |.|       :.|..|...|..
Human   352 VEASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHSGEKP-------YECHICHTRFTQ 409

  Fly   442 EQNYDAHV 449
            ......|:
Human   410 SGTMKIHI 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZIPIC	NP_651765.1	C2H2 Zn finger	286..306	CDD:275368	7/19 (37%)
		C2H2 Zn finger	314..334	CDD:275368	5/19 (26%)
		SFP1	<336..419	CDD:227516	28/82 (34%)
		C2H2 Zn finger	342..391	CDD:275368	13/48 (27%)
		zf-H2C2_2	383..408	CDD:463886	12/24 (50%)
		C2H2 Zn finger	399..419	CDD:275368	6/19 (32%)
		C2H2 Zn finger	432..449	CDD:275368	3/16 (19%)
CTCFL	NP_001255972.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..55		11/69 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	221..250		6/38 (16%)
		COG5048	<259..403	CDD:227381	47/150 (31%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		C2H2 Zn finger	287..307	CDD:275368	5/19 (26%)
		C2H2 Zn finger	315..333	CDD:275368	6/17 (35%)
		C2H2 Zn finger	344..364	CDD:275368	6/19 (32%)
		C2H2 Zn finger	372..392	CDD:275368	6/19 (32%)
		SUF4-like	<392..>432	CDD:411020	7/33 (21%)
		C2H2 Zn finger	400..421	CDD:411020	4/18 (22%)
		C2H2 Zn finger	400..417	CDD:275368	3/16 (19%)
		C2H2 Zn finger	430..448	CDD:275368
		SUF4-like	459..>492	CDD:411020
		C2H2 Zn finger	460..485	CDD:411020
		C2H2 Zn finger	460..480	CDD:275368
		C2H2 Zn finger	488..508	CDD:275368
		C2H2 Zn finger	516..534	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	569..630