DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZIPIC and znf1014

DIOPT Version :9

Sequence 1:	NP_651765.1	Gene:	ZIPIC / 43566	FlyBaseID:	FBgn0039740	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001108370.1	Gene:	znf1014 / 100141333	ZFINID:	ZDB-GENE-080220-9	Length:	508	Species:	Danio rerio

Alignment Length:	271	Identity:	80/271 - (29%)
Similarity:	120/271 - (44%)	Gaps:	33/271 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 VEEVAHEIEEVAHEIEEEDLLPHDKQEAQEEDFFKEDTMSDFDEHLDGAIEYIISDGEDQEQDNE 248
            |:::..|.:|...:.||...|...|:|.:|   .||:   :.:...|||:      ||.|.|..:
Zfish     7 VKKIIKEEQENTGDTEEHRALMIVKEEERE---IKEE---EEEGCQDGAV------GETQSQPAD 59

  Fly   249 SSGEYTVNIQCPSCPEKFSSRRAYNVHTKREH------FPGYVCDQCGKTLQSYSGFIGHLQNHE 307
            :...:|    ||.|.:.|..:     |..::|      ...:.|.:|||:.:..|....|::.|.
Zfish    60 TETVFT----CPQCGKSFRKK-----HYLKQHIGIHIGLKPFACAECGKSFRIKSSLEVHMRLHT 115

  Fly   308 PVKQFACPVCPERFSRKFRLKHHMAWHSGETPYQCDVCSKRFVHKVALYKHKMIHDSETKRLECQ 372
            ..|.|.|.:|.:.|.|......|...|..|.|:.||.|.|.|.....|..||:||..| |...|.
Zfish   116 GEKPFTCSLCGKSFRRSGTFDDHQRIHFEEKPFTCDECGKSFKWANCLQIHKLIHSGE-KPFGCD 179

  Fly   373 VCGFKTRTKAHLERHMRSHTGDKPFACPVCNKRFSQMYNMKAHLREHESPGTNRHRRFHCSKCTH 437
            .||.:...|:.|..||.|||.:||::|..|.|.|:::...:.|.:.|  .|.|   .:.|:.|..
Zfish   180 QCGKRYIQKSELRDHMMSHTNEKPYSCEFCGKGFARLCRFRHHQKTH--TGVN---EYSCTDCGQ 239

  Fly   438 TFINEQNYDAH 448
            ||.......||
Zfish   240 TFTTFTLLKAH 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZIPIC	NP_651765.1	C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		C2H2 Zn finger	314..334	CDD:275368	5/19 (26%)
		zf-H2C2_2	327..351	CDD:290200	9/23 (39%)
		C2H2 Zn finger	342..391	CDD:275368	19/48 (40%)
		zf-H2C2_2	383..408	CDD:290200	12/24 (50%)
		C2H2 Zn finger	399..419	CDD:275368	5/19 (26%)
		C2H2 Zn finger	432..449	CDD:275368	6/17 (35%)
znf1014	NP_001108370.1	C2H2 Zn finger	66..86	CDD:275368	6/24 (25%)
		COG5048	90..476	CDD:227381	55/167 (33%)
		C2H2 Zn finger	94..114	CDD:275368	6/19 (32%)
		C2H2 Zn finger	122..142	CDD:275368	5/19 (26%)
		C2H2 Zn finger	150..170	CDD:275368	8/19 (42%)
		C2H2 Zn finger	178..198	CDD:275368	7/19 (37%)
		C2H2 Zn finger	206..226	CDD:275368	5/19 (26%)
		C2H2 Zn finger	234..254	CDD:275368	6/17 (35%)
		C2H2 Zn finger	262..282	CDD:275368
		C2H2 Zn finger	290..310	CDD:275368
		C2H2 Zn finger	318..338	CDD:275368
		C2H2 Zn finger	346..366	CDD:275368
		C2H2 Zn finger	374..394	CDD:275368
		C2H2 Zn finger	402..422	CDD:275368
		C2H2 Zn finger	430..450	CDD:275368
		C2H2 Zn finger	458..478	CDD:275368
		C2H2 Zn finger	486..503	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24406
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100